作 者 :闫小平,官仕杰,郑蕊,伊博文,王永刚,朱永红
期 刊 :中国中药杂志 2011年 36卷 21期 页码:2960.
关键词:基质 ;伤湿止痛膏 ;经皮渗透 ;
Keywords:bases , patches Shangshi Zhitong , percutaneous permeability ,
摘 要 :目的: 以伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品累积透过率为考察指标,研究新、旧2种不同基质的伤湿止痛膏的体外透皮特性。 方法: 利用改良扩散池进行体外透皮试验,用HPLC测定透皮接受液中马钱子碱、士的宁和硫酸阿托品含量。 结果: 新基质(热熔压敏胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品在72 h内平均累积透过率分别为53.25%,74.52%,34.32%;旧基质(天然橡胶)伤湿止痛膏中马钱子碱、士的宁和硫酸阿托品平均累积透过率分别为54.90%,50.24%,46.54%。 结论: 新基质较旧基质更利于亲脂性药物的释放,且释放更稳定。
Abstract:Objective: To study the percutaneous permeability of patches Shangshi Zhitong on different kinds of bases with the permeation percentage of brucine, strychnine and atropine. Method: Using modified Franz difusion to investigate the penetration quantity of brucine, strychnine and atropine. The contents of brucine, strychnine and atropine were determined by HPLC. Result: The average accumulative permeation percentage of brucine, strychnine and atropine on new base were 53.25%,74.52% were 34.32%, respectively, and on old base are 54.90%,50.24%,46.54%, respectively. Conclusion: The new base benefits the lipophilic drugs and releases more stably.
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