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作 者 ：夏芳,孙建,姜勇,屠鹏飞

期 刊 ：中国中药杂志 2013年 38卷 19期 页码：3299.

关键词：沉香属；白木香叶；二苯甲酮；黄酮苷；酚类；

Keywords:Aquilaria sinensis, leaves of Aquilaria sinensis, chemical constituents,

摘 要 ：为综合利用白木香叶的丰富资源,阐明其物质基础,课题组再次对其化学成分进行了研究,采用多种色谱技术对其化学成分进行分离纯化,从白木香叶95%,70%乙醇提取物的氯仿和正丁醇萃取部位共分离得到12个化合物.经多种波谱方法鉴定其结构,分别为鸢尾酚酮2-(O-α-L)-吡喃鼠李糖苷(3),4‘-羟基-5-甲氧基黄酮-7-O-葡萄糖(6-1)木糖苷(2),7,3‘,5‘-三甲氧基黄酮苷(3),5-甲氧基芹菜素7-(O-β-D)-葡萄糖苷(4),2-苯乙基1-O-β-D-吡喃葡萄糖苷(5),红景天苷(6),苯甲醇1-O-β-D-吡喃葡萄糖苷(7),2,6-二甲氧基-4-羟基苯酚-1-O-β-D-吡喃葡萄糖苷(8),vanilloloside(9),(+)-丁香脂素(10),β-维生素E(11),豆甾-5-烯-3β,7α-二醇(12),化合物 2,3,5~9,11和12 为首次从该属植物中分离得到.另外,对氯仿萃取部位的9个流分进行了4种人体肿瘤细胞毒活性筛选,均未显示明显活性.

Abstract:To comprehensively utilize the rich resource of Aquilaria sinensis,the ethanol extract of the leaves of A. sinensis was further chemically investigated,which led to the isolation of 12 compounds. By means of ¹H-,¹³C-NMR,and ESI-MS data,and through comparison with those reported in literatures,their structures were identified as iriflophenone 2-(O-α-L)-rhamnoside(1),4‘-hydroxy-5 methoxyflavone-7-O-glucoxyloside(2),7,3‘,5‘-tri-O-methyltricetin(3),7-O-β-D-glucopyranoside of 5-O-methylapigenin(4),2-phenylethyl-D-glucopyranoside(5),salidroside,(6),benzyl alcohol O-β-D-glucopyranoside (7),2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside(8),vanilloloside(9),(+)-syringaresinol(10),β-tocopherol(11)and stigmast-5-ene-3β,7α-diol(12). Among them,compounds 2,3,5-9,11 and 12 were isolated from this genus for the first time. This research hopefully provides valuable data for the further utilization and development of the leaves of A. sinensis.

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