目的：探讨中药复方千金黄连丸加味方对谷氨酸钠(monosodium L glutamate，MSG)诱发的胰岛素抵抗(insulin resistance，IR)模型小鼠肾脏的影响。方法：以中药复方千金黄连丸加味方干预MSG IR小鼠模型，与罗格列酮作对照，测定空腹血糖、血清胰岛素水平、胰岛素敏感指数、小鼠的尿蛋白排泄量及肾小球直径，观察肾脏形态学变化。结果：给药2周，中药小剂量组尿白蛋白的排泄量减少，与模型组相比差异显著(P<0.05)。给药4周，中药大剂量组空腹血糖较模型组明显下降(P<0.001)，胰岛素敏感指数较模型组升高(P<0.05)，与罗格列酮组间无统计学差异。中药高、低剂量组肾小球肥大减轻，与模型组相比差异显著(P<0.01)，与罗格列酮组无明显差异。结论：中药复方千金黄连丸加味方能减轻IR，减少IR小鼠的尿白蛋白的排泄量，改善IR相关性肾脏病理改变。
Objective: To investigate the effect of Qianjin Huanglian pill on kidney in monosodium L glutamate (MSG) treated insulin resistance (IR) mice. Method: The ameliorative effect of Qianjin Huanglian pill on IR in MSG mice was evaluated in comparison with rosiglitazone (Ros). The fasting serum glucose, fasting serum insulin, insulin sensitivity index, urinary albumin excretion, glomerular diameter and pathological changes of kidney were investigated in the evaluation. Result: After 2 weeks of Qianjin Huanglian pill treatment, the urinary albumin excretion (UAE) was reduced in low dose group (P<0.05) as compared with the model group. After 4 weeks of Qianjin Huanglian pill treatment, the fasting serum glucose was reduced in high dose group (P<0.001 compared with the model group). ISI of mice was ameliorated in high dose group (P<0.05 compared with the model group). The glomerular diameter was decreased, the hyperplasia of glomerulus was ameliorated in high dose and low dose groups (P<0.01 compared with model group). Conclusion: In MSG mice, we found Qianjin Huanglian pill could increase insulin sensitivity, decrease the urinary albumin excretion, ameliorate the pathological changes of kidney due to insulin resistance.