---

期 刊 ：中国中药杂志 2008年 33卷 05期 页码：564.

关键词：中药；肝硬化；肝细胞功能；

Keywords:hepatocirrhosis, hepatocellular function, scintigraphy,

摘 要 ：目的:分析大黄虫丸对肝炎肝硬化患者的肝细胞功能的影响。方法:对37例肝炎肝硬化患者及12例正常对照者进行肝胆动态显像定量分析肝细胞功能,其中19例患者给予大黄虫丸治疗后6月复查了肝胆显像,比较治疗前后肝细胞摄取和排泄功能变化,并监测其肝功能指标变化。结果:肝炎肝硬化组摄取高峰时间、平均残存指数均显著高于正常组(P<0.01),摄取指数、摄取速度指数、排泄速度指数均显著降低(P<0.05)。大黄虫丸治疗后肝炎肝硬化患者转氨酶、胆红素、球蛋白等肝功能生化指标均明显降低(P<0.01)。患者肝细胞的摄取高峰时间显著缩短,摄取指数均显著提高,(P<0.01);摄取速度明显提高(P<0.05);肝细胞平均残留指数显著降低(P<0.01)。结论:大黄虫丸不仅可改善肝炎肝硬化患者肝功能状态,还可提高患者肝细胞摄取和排泄功能。

Abstract:Objective:To evaluate the influence of Chinese drug Dahuang Zhechong pill on the hepatocellular function.Method:Thirty-seven patients with hepatocirrhosis and twelve normal controls were performed the hepatobiliary scintgraphy with Tc-99m labeled ethylene hepatobiliary iminodiacetic acid(^{99 m}Tc-EHIDA),and the biochemical examination of hepatic function.There was 19 cases repeated the imaging after 6 months treated with chineses drug.By the three compartmental model configurations,the function parameters of hepatocellular extraction and excretion were calculated.Result:In the hepatocirrhosis groups,the hepatocellular uptake peak time and mean residence index were higher than those in normal controls(P<0.01).Compared to normal controls,the uptake index,uptake speed index and descendent speed index were decreased markedly(P<0.05).After treatment for 6 months with Chinese drug,the level of serum transaminase,globulin and bilirubin was lower than that before treatment.The uptake peak time and mean residence index decreased notably after treatment for 6 months(P<0.01),and the uptake index increased,(P<0.05).Conclusion:Chinese drug Dahuang Zhechong pill may improve the hepatocellular function and liver function status in patients with hepatocirrhosis.

---