目的：研究加味三棱丸(SLW)对子宫内膜异位症移植物的抑制作用和探讨对黏附分子ICAM-1，CD44表达的影响。方法：采用子宫内膜自体移植法建立大鼠子宫内膜异位症模型，用游标卡尺、HE染色和免疫组化分别检测子宫内膜异位症移植物体积变化、异位内膜组织形态学改变和黏附分子ICAM-1，CD44的表达。结果：SLW 0.11，1.02 g·kg-1均可以明显减小子宫内膜异位症移植物的体积；显微形态显示：给药组与模型组比较其病理改变程度减轻，异位内膜为薄单层细胞排列而非腺体数目多，细胞呈多层排列，腺上皮呈扁平或矮立方形，未见假腺体改变；SLW 1.02，0.11 g·kg-1均能明显降低了异位子宫内膜黏附分子ICAM-1，CD44的蛋白表达。结论：SLW可显著抑制子宫内膜异位症移植物生长，其作用机制可能与抑制黏附分子ICAM-1，CD44的蛋白表达水平有关。
Objective: To explore the effect of Sanlengwan (SLW) on adhesion molecules expression and the accretion in ectopic endometrium of rats. Method: Endometriosis was established by surgical implant of endometrial tissue which belong to its body. Forty EMS model rats were randomly divided into five groups: model control group, three dose of SLW groups and anastrozole group. Meanwhile, eight normol rats were used as the normal group. All the rats were treated for 4 weeks respectively, and the volume of grafts were measured by vernier caliper, morphological changes were measured by HE stain, and the adhesion molecules, ICAM-1 and CD44 protein, were also measured by immunohistochemical test before and after treatment of SLW. Result: SLW markedly reduced the volume of grafts, improve the morphological characters and decreased the expression of ICAM-1 and CD44 in ectopic endometrial tissue. Conclusion: SLW can inhibit the accretion of ectopic endometrium tissue of rats, and its mechanism might be associated with inhibiting the expression of ICAM-1 and CD44 protein.