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期 刊 ：中国中药杂志 2005年 30卷 14期 页码：1108.

关键词：子宫内膜异位症；细胞因子；香桂丸；

Keywords:endometriosis, cytokine, Xianggui pill,

摘 要 ：目的:研究中药香桂丸对子宫内膜异位症模型鼠细胞因子的调节作用,以探讨香桂丸治疗子宫内膜异位症的作用机理。方法:采用大鼠自体子宫内膜移植法建立实验性子宫内膜异位症模型,分组后分别灌服生理盐水、香桂丸煎剂及丹那唑,用ELISA法检测白细胞介素-8(IL-8),肿瘤坏死因子-α(TNF-α)含量。结果:模型组外周血、腹腔液IL-8,TNF-α含量均高于空白对照组;香桂丸组及丹那唑组异位种植内膜组织质量、腹腔液巨噬细胞数量及IL-8,TNF-α含量均低于模型组;但香桂丸组与丹那唑组间各项指标差异不显著。结论:香桂丸可显著抑制异位内膜组织的生长,并对细胞因子有明显的调节作用。

Abstract:Objective: To study the adjustment of Xianggui pill on the cytokine of endometriosis model rat, and investigate the mechanism of Xianggui pill on the treatment of endometriosis. Method: To set up endometriosis model by rat self-endometria transplantation, drench sodium chloride,Xianggui pill elixation or Danazol after grouping, and to detect the contents of interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α) by ELISA. Result: The contents of IL-8,TNF-α in the peripheral blood and peritoneal fluid of model group were higher than that of the blank group; The quality of allotopia growth intima tissue, the quantity of macrophage in peritoneal fluid and the contents of IL-8,TNF-αin the Xianggui pill group and Danazol group were all lower than those of the model group; but there was no significont difference of each target between the Xianggui pill group and Danazol group. Conclusion: Xianggui pill can restrain significantly the growth of allotopia intima tissue, and has apparently adjustment to the cytokine.

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