---

作 者 ：李忠红,樊夏雷,蔡美明,杨志宏,应剑,强桂芬,杜冠华

期 刊 ：中国中药杂志 2009年 34卷 23期 页码：3110.

关键词：有效成分组；防己诺林碱；粉防己碱；药动学；

Keywords:effective compound group(ECG), fangchinoline, tetrandrine, pharmacokinetics,

摘 要 ：目的：对防己诺林碱与粉防己碱两种化合物在大鼠体内的药动学及复方给药的影响进行研究。方法： 采用高效液相色谱-质谱联用技术，建立了防己诺林碱与粉防己碱的血药浓度检测方法，并对单体给药与小续命汤有效成分组给药两种情况下两个化合物的药动学参数进行对比。 结果：与有效成分组给药相比，单体给药防己诺林碱与粉防己碱的T_max显著延长，其余参数没有大的差异。 结论：有效成分组中其他成分减慢了二者在体内的吸收速度，与单体给药相比，有效成分组给药时防己诺林碱与粉防己碱的生物利用度不变。

Abstract:Objective： To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription. Method： A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared. Result： Compared with the single dose of compound experiment results, the tmax of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference. Conclusion： Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.

---