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作 者 ：陈婧,万毅刚,卞茸文,顾刘宝,王朝俊,张慧兰,姚建

期 刊 ：中国中药杂志 2010年 35卷 4期 页码：525.

关键词：糖尿病肾病；中药；药理机制；

Keywords:diabetic nephropathy, Chinese herbal medicine, pharmacological mechanism,

摘 要 ：糖尿病肾病(diabetic nephropathy,DN)发病过程中所出现的肾小球硬化性损伤与糖代谢、足细胞、肾脏血流动力学、致纤维化细胞因子、氧化应激、炎症反应等因素有关。中药可以调节糖代谢异常,保护足细胞损伤,改善肾脏血流动力学障碍,下调致纤维化细胞因子表达,缓解氧化应激,抑制炎症反应等,从而延缓DN向终末期肾病发展的进程。

Abstract:The pathomechanisms of glomerulosclerosis in diabetic nephropathy (DN) are considered to be related with glycometabolism disorder, podocyte injury, intra-renal hemodynamics abnormality, fibrogenic cytokines over-expression, oxidative stress and inflammatory reaction. Chinese herbal medicine could delay the progression of glomerulosclerosis in DN by ameliorating the harmful factors of these pathological changes. Therefore, it is possible to postpone the progress of DN to end-stage renal disease through the treatment with Chinese herbal medicine.

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