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期 刊 ：中国中药杂志 2008年 33卷 02期 页码：184.

关键词：葫芦巴属；糖尿病；2型；磺脲类降糖药；继发性失效；

Keywords:Trigonella, diabetes mellitus, type 2, sulphanylureas, secondary failure to sulfonylurea,

摘 要 ：目的:观察葫芦巴总皂苷(TFGs)与磺脲类降糖药(SU)合用对继发性失效2型糖尿病(T2DM)的临床疗效。方法:72例单纯使用SU血糖控制不良的T2DM患者,按就诊顺序随机分为对照组(36例)和治疗组(36例),在服用SU的基础上,分别加服安慰剂和TFGs,观察其疗效。结果:治疗组总有效率明显高于对照组(P<0.01);与治疗前相比,治疗组空腹血糖、餐后2 h血糖、糖化血红蛋白、临床症状积分显著下降(P均<0.01),体重指数和肝肾功能无明显变化。结论:TFGs联合SU治疗T2DM,显示了较好的降糖效果,同时能改善临床症状,且有较好的安全性。

Abstract:Objective: To observe the clinical efficacy of Trigonella foenum-graecum saponin(TFGs) in patients with type 2 diabetes mellitus(T2DM) not well controlled by western medicine.Method: Seventy two T2DM patients,whose blood glucoses were not well controlled by oral sulfonylureas hypoglycemic drug,were randomly assigned to control group(36 cases) and treatment group(36 cases).Aside from their original western medicine,the subjects were respectively given placebo and TFGs for 12 weeks.Result: After treatment,the total effective rate in treatment group was remarkably higher than in control group(P<0.01),and the indexes of fast plasma glucose(FPG),plasma glucose 2 hours after meals(2 h PG),glycosylated hemoglobin(HbA1c) and clinical symptomatic accumulated points(CSAP) decreased significantly in treatment group(P<0.01),while no obvious changes were shown in the indicators of BMI,hepatic and renal function.Conclusion: The combined therapy of TFGs together with sulfonylureas hypoglycemic drug could not only decrease blood glucose,but also ameliorate clinical symptoms with very good safety.

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