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作 者 ：杨德刚,卢年芳,刘筱洁,刘刚,徐耀,黄金忠,陈应柱

期 刊 ：中国中药杂志 2010年 35卷 10期 页码：1339.

关键词：急性脑梗死；TOAST分型；纤维蛋白原；松龄血脉康；

Keywords:acute ischemic stroke, TOAST criteria, fibrinogen, Songling Xuemaikang,

摘 要 ：目的: 探讨急性脑梗死TOAST各分型纤维蛋白原水平(Fbg)的变化及松龄血脉康的干预效果。 方法 : 将160例住院急性脑梗死患者随机分为治疗组和对照组,其中治疗组(松龄血脉康胶囊+疏血通注射液+拜阿司匹林组)85例,对照组(疏血通注射液+拜阿司匹林组)75例,检测各亚型的Fbg水平。 结果 : 大动脉粥样硬化脑梗死(LAA)、心源性脑栓塞(CE)、小动脉闭塞脑梗死(SAO)血清Fbg与其他明确病因的脑梗死(OC)比较有统计学意义(P<0.05),LAA、CE、SAO与不明病因性脑梗死(UE)比较有统计学意义(P<0.05),LAA与SAO比较有统计学意义(P<0.05)。治疗组TOAST各型中LAA,CE,SAO治疗前后比较有显著差异(P<0.05);15 d后治疗组LAA,CE,SAO 3型与对照组比较有显著性差异(P<0.05)。 结论 : Fbg在大动脉粥样硬化型梗死、心源性脑栓塞、小动脉闭塞型脑梗死的发生发展中都发挥着重要作用。松龄血脉康可显著降低脑梗死患者的Fbg水平,可作为脑梗死的有效辅助治疗药物。

Abstract:Objective : To investigate the changes of plasma fibrinogen level among acute ischemic stroke(ACI) subtypes according to Trial of Org10172 in Acute Stroke Treatment (TOAST) criteria and effects of Songling Xuemaikang. Method : The 160 patients with acute iachemic stroke were divided into two groups randomly: treatment group 85 cases (Songling Xuemaikang + Shuxuetong+ Aspirin enterie ccoated tablets), control group 75 cases (Shuxuetong + Aspirin enterie ccoated tablets).The plasma fibrinogen was detected before and after treatment. Result : Compared with OC subtype, Fbg was higher in LAA, CE and SAO subtypes (P<0.05). Compared with UE subtype, Fbg was higher in LAA, CE and SAO subtypes (P<0. 05). There was a significantly difference between LAA and SAO (P<0.05). In LAA,SAO,CE of treatment group,the Fbg level were lowered significantly at the 15th day compared with pretherapy (P<0.05). There was a significantly difference of Fbg between treatment group and control group In LAA, SAO and CE subtypes at the 15th day (P<0.05). Conclusion : Fbg produces a marked effect at the pathomechanism of LAA, SAO and CE subtypes. Songling Xuemaikang can depress the plasma fibrinogen level of ACI, and be an effective adjunctive therapy on ACI.

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