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作 者 ：汪浩,舒跃民,郑海文,武东,黄斌伦,高素华

期 刊 ：中国中药杂志 2010年 35卷 6期 页码：786.

关键词：良性前列腺增生症；细胞因子；中药；前列宁汤；干预；

Keywords:benign prostatic hyperplasia, cytokines, traditional Chinese medicine, Qianliening Tang, intervene,

摘 要 ：目的: 研究良性前列腺增生症细胞因子水平与中药干预的影响。 方法 :采用随机病例对照设治疗组(A组),对照组(B组)及健康组(C组)。A组用前列宁汤,每日1剂,分2次口服。 B组用前列康3片/次,每日3次口服,2组疗程均8周。 结果 :治疗前AB组TNF-α,IL-17/IL-10,IL-4与C组比明显失调(P＜0.01)。治疗后A组TNF-α,IL-17明显降低,IL-10,IL-4明显提高,与治疗前比有显著性差异(P＜0.01)。与B组比有显著性差异(P＜0.01)。但仍然达不到C组水平。 结论 : 前列宁汤能有效调节前炎症细胞因子与抗炎症细胞因子的水平,为临床诊断与治疗BPH提供科学实验依据。

Abstract:Objective : To make a study of the influence of the intervene of traditional Chinese medicine on cytokine level in benign prostatic hyperplasia. Method : The patients were divided into treatment group (group A), control group (group B) and healthy group (group C) with the randomly compared researching method. Group A were given Qianliening Tang (QLNT), daily potion, two times a day. Group B were given Qianliekang, three times a day, three pills each time. The course of both treatment lasted for 8 weeks. Result : Before treatment, TNF-α, IL-17/IL-10, IL-4 in group A and B are obviously out of order compared with group C (P＜0.01). After the treatment, TNF-α, IL-17 in group A decreased dramatically and IL-10, IL-4 increased, which shows great differences compared with those before treatment and with group B(P＜0.01), but still can’t reach to group C level. Conclusion : Qian liening Tang can efficiently regulate the level of suppressive inflammatory cytokines and proinflammatory cytokines. It provides scientific experimental basis for clinical diagnosis and treatment of the disease.

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