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期 刊 ：中国中药杂志 2007年 32卷 16期 页码：1703.

关键词：无患子皂苷；血管紧张素Ⅱ；醛固酮；内皮素；一氧化氮；肾性高血压；

Keywords:sapindoside, angiotensin Ⅱ(AngⅡ), aldosterone(Ald), endothelin(ET), nitric oxide(NO),

摘 要 ：目的：观察无患子皂苷对肾性高血压大鼠(renovascular hypertension rat,RHR)的降压作用及对血管紧张素Ⅱ(AngⅡ)、醛固酮(Ald)、内皮素(ET)、一氧化氮(NO)的影响。方法：采用改进的两肾一扎(2K1C)高血压大鼠模型。将大鼠均分为6组：假结扎组、模型组、卡托普利组、无患子皂苷高、中、低3个剂量组。每组10只,每天灌胃给药1次,假结扎组和模型组灌服等量蒸馏水。分别于给药后1,3,7,14,21,28,35 d测量大鼠尾动脉收缩压；取血测血中AngⅡ,Ald,ET,NO的浓度。结果：无患子皂苷给药35 d能明显降低RHR血压。RHR血浆中AngⅡ,Ald,ET含量增多,NO含量降低,无患子皂苷各剂量降低血压同时能够降低AngⅡ,Ald,ET含量,增加NO含量。结论：无患子皂苷能够降低RHR血压,并对AngⅡ,Ald,ET,NO产生一定影响,可能是其降压作用的机制之一。

Abstract:Objective: To observe the effects of sapindoside on blood pressure, AngⅡ, Ald, ET in the blood plasma and NO in the serum in renovascular hypertension rat. Method: The 2K1C (2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 5 weeks. The blood pressure was messured at the 1, 3, 7, 14, 21, 28, 35 day after drug. At the end of 5th weeks, the AngⅡ, Ald, ET in the blood plasma and NO in the serum were measured. Result: Sapindoside (H, M and L) by ig. for 5 weeks could significantly lower the blood pressure, increase the levels of NO in the serum, reduce the concentration of AngⅡ, Ald, ET in the blood plasma. Conclusion: sapindoside plays an important role in decreasing the blood pressure of renovascular hypertension rat.

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