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期 刊 ：中国中药杂志 2007年 32卷 17期 页码：1783.

关键词：中药；免疫药理；文献信息学；

Keywords:Chinese medicine, immunopharmacology, literature informatics,

摘 要 ：目的：据已发表的有关中药免疫研究文献为研究基础,分析中药特征与免疫效应的关系并建立相应的数学模型。方法：收集、筛选1980年以来国内公开发表的《中国药典》所载中药植物药免疫研究的文献,根据检索结果统计不同生物分类、不同药性、药味、归经、不同入药部位的中药数量和其中具有免疫作用的中药味数；用多元判别分析建立回归数学模型。结果：味辛的药物具有免疫作用的比例较低(P<0.05)；地下部分入药的中药具有免疫作用的比例较高(P<0.05)；归心经、肾经的药物具有免疫作用的比例较高(P<0.05)；多元判别分析结果与原判定结果符合率为74.7%。结论：中药的药味、药物归经及入药部位与免疫调节作用有关,以此为基础建立的数学模型可以作为中药免疫药理研究的参考。

Abstract:Objective: Intends to create mathematical model and analysis of correlation between Chinese medicinal characteristics and immunoregulatory activity based on literature informatics. Method: The numbers of the Chinese medicines with immune effects were worked out within the framework of “The China Pharmacopeia” of 2005 edition, from the literature publicized since 1980. The correlation and mathematical model were figured out between Chinese medicinal characteristics including biological classification, different tastes, channel tropism as well as the parts used and immunoregulatory activity based on the statistical software SPSS. Result: The results showed that the immunoregulatory activity was related to the five tastes of Chinese medicines, and the pungent medicines had less immune effect. The Chinese medicines of underground parts had more immune effect compared with other parts of the medicine. Medicines acting upon heart and kidneys were more powerful as for the immune effects (P<0.05). The coincidence was 74.7% between mathematical computing and original classification. Conclusion: There are correlations between Chinese medicinal characteristics and immunoregulatory activity. The mathematical model based on these results can be used for immunopharmacology.

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