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期 刊 ：中国中药杂志 2007年 32卷 12期 页码：1203.

关键词：玉米须多糖；胃排空；肠蠕动；胆囊收缩素；

Keywords:stigma maydis polysaccharide(SMPS), gastric emptying, intestine wriggling, cholecystokinin(CCK),

摘 要 ：目的：研究玉米须多糖(SMPS)对实验动物胃肠运动的影响。方法：以黑色炭末为指示剂,以正常小鼠小肠炭末推进百分率、小鼠首次排黑便时间和数量为指标,观察SMPS(0.5,1,2 g·kg^-1)对小鼠肠运动的影响；以甲基橙为指示剂,以甲基橙残留率为指标,观察SMPS(0.5,1,2 g·kg^-1)对小鼠胃排空的影响；以美蓝为指示剂,以胃排空时间、肠内容物移动速度为指标,观察SMPS对大鼠胃肠运动的影响；观察SMPS对大鼠血浆中胆囊收缩素(CCK)含量的影响。结果：与空白组相比,SMPS可使小鼠小肠炭末推进百分率显著性增加(P<0.01)；小鼠首次排黑便时间显著性缩短(P<0.01),排便数量显著性增加(P<0.01)；小鼠甲基橙胃残留率显著性增加 (P<0.01)；大鼠胃排空的时间显著性延长(P<0.01),大鼠肠内容物移动速度显著性加快(P<0.01)；大鼠血浆中胆囊收缩素(CCK)含量显著性升高(P<0.05)。结论：SMPS对胃肠运动的影响可能与其升高血浆中CCK含量有关。

Abstract:Objective: To study the effect of stigma maydis polysaccharide (SMPS) on gastrointestinal movement. Method: Taking charcoal as the indicator and taking ratio of charcoal movement, beginning time of black excretion and stool amount as the index to observe the effect of SMPS on intestinal movement in mice. Taking emthylorange as the indicator and taking the ratio of residual rate of methylorange as the index to observe the effect of SMPS on gastric emptying in mice. Taking methylene blue as the indicator and taking the time of gastric emptying and movement speed of intestinal content as the index to observe the effect of SMPS on gastrointestinal movement in rats. Observing the changes of cholecystokinin (CCK) level in plasm in rats. Result: Compared with control, the ratio of charcoal movement increased in mice (P<0.01).The beginning time of black excretion shortened and the stool amount increased in mice (P<0.01).The ratio of residual rate of methylorange increased in mice (P<0.01).The time of gastric emptying prolonged in rats (P<0.01).The movement speed of intestinal content in rats accelerated (P<0.01).CCK level in plasm increased in rats (P<0.05). Conclusion: Effects of stigma maydis polysaccharide on gastrointestinal movement are probably related to the increasing of CCK level in plasm.

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