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期 刊 ：中国中药杂志 2006年 31卷 03期 页码：239.

关键词：菝葜；醋酸乙酯提取物；抗炎作用；

Keywords:Smilax china, ethyl acetate extract, antiinflammations,

摘 要 ：目的:研究菝葜醋酸乙酯提取物对大鼠和小鼠急性、慢性炎症的抗炎作用。方法:采用蛋清致足肿胀、甲醛致足肿胀、二甲苯致耳肿胀和醋酸致腹膜炎模型,对菝葜醋酸乙酯提取物对急性(早期)、慢性(晚期)炎症的抗炎作用进行研究,处理为正常对照组:生理盐水,10 mL.kg^-1;乙酰水杨酸阳性对照组(200 mg.kg^-1);菝葜提取物剂量为生药50,100 g.kg^-1剂量组,均灌胃给药。结果:在生药50～100 g.kg^-1剂量范围内,提取物能显著降低蛋清诱导的大鼠足跖肿胀度、甲醛诱导的小鼠足肿胀程度、小鼠腹腔毛细血管通透性增高和二甲苯诱导的耳廓肿胀,同时对炎症晚期也有一定的抑制作用。结论:菝葜醋酸乙酯提取物对急性、早期炎症具有明显的抗炎作用,对炎症晚期也有一定的抑制作用。

Abstract:Objective: To study the anti-inflammations of the ethyl acetate extract of S.china on acute and chronic inflammations.Method: The rat paw edema induced by egg-albumin,the ear edema and the foot edema of mice induced by xylene and formaldehyde,the increased vascular permeability of capillary induced by intraperitoneal injection of 0.7% acetic acid in mice were used to study on the acute,early inflammations and chronic inflammation for the ethyl acetate extract of S.china.Result: The extract(50-100 g·kg^-1) could significantly decrease the rat paw edema,and inhibit the ear edema,the increased vascular permeability and the foot edema of mice.Conclusion: The ethyl acetate extract of S.china possesses remarkable anti-inflammatory effects on acute inflammation,and also displays anti-inflammatory effects on the chronic inflammation at a certain extent.

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