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期 刊 ：中国中药杂志 2007年 32卷 08期 页码：732.

关键词：血管性痴呆；颐神养脑胶囊；事件相关电位P300；中医证候；临床观察；

Keywords:vascular dementia, Yishen Yangnao capsule, P300, Chinese medicine syndrome, clinical research,

摘 要 ：目的：寻找诊断血管性痴呆的有效方法,观察颐神养脑胶囊治疗血管性痴呆的疗效以及中医证候的演变规律。方法：以都可喜片为阳性对照,评价颐神养脑胶囊治疗血管性痴呆(肝肾亏虚、髓海不足证)的随机、双盲、平行对照、安全性、有效性的Ⅲ期临床试验,并对部分患者进行了事件相关电位P₃₀₀的检查。结果：颐神养脑胶囊治疗血管性痴呆患者的总有效率为56.3%(对照组60.0%)；ADL积分改善率为0.1069％(对照组0.1134％)；中医症状积分下降。结论：颐神养脑胶囊治疗血管性痴呆在改善患者智能状况、生活能力方面与都可喜同样有效。

Abstract:Objective: To find a good way to diagnose VD, value the effect of Yishen Yangnao capsule on VD and try to find some rules of changes in Chinese medicine syndromes. Method: Patients were randomly divided into treating group and western medicine comparison group. It’s the phase Ⅲ clinical research of Yishen Yangnao capsule curing VD, judging the validity and security of it, using Dukexi slice as comparison drug. Some of the patients did the examination of P₃₀₀. Result: The total validity of Yishen Yangnao capsule is 56.3% (contract team is 60.0%). The improve rate of ADL is 0.106 9％ (contract team is 0.1134％). The scores of Chinese medicine syndrome descend. Conclusion: Yishen Yangnao capsule has the same effect as Dukexi slice in curing VD at the side of intelligence situation and life ability.

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