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期 刊 ：中国中药杂志 2006年 31卷 04期 页码：295.

关键词：甘草酸；大孔吸附树脂；吸附性能；解吸性能；

Keywords:glycyrrhizic acid, mcroporous resin, adsorption, desorption,

摘 要 ：目的:研究AB-8,D-101,H-103 3种大孔吸附树脂对甘草酸的吸附及解吸性能。方法:以HPLC测定3种树脂对甘草酸的静态吸附量、解吸率、最大比吸附量及动态解吸率,比较3种树脂对甘草酸的吸附与解吸性能。结果:AB-8甘草药材最大上样量为0.75 g药材/mL树脂,最佳洗脱剂为50%乙醇,洗脱率68.81%;D-101甘草药材最大上样量为0.75 g药材/mL树脂,最佳洗脱溶剂为60%乙醇,洗脱率64.67%;H-103甘草药材最大上样量为0.5 g药材/mL树脂,最佳洗脱溶剂为60%乙醇,洗脱率51.18%。结论:AB-8,D-101是适于吸附甘草酸的较好的吸附剂。

Abstract:Objective: To investigate the performance of static and dynamic adsorption and desorption of the three macroporous resins of AB-8,D-101 and H-103.Method: Compare the adsorption and desorption of the three macroporous resins for glycyrrhizic acid by determining the static adsorption,static desorption,dynamic adsorption and dynamic desorption through detecting the glycyrrhizic acid content by HPLC method.Result: The saturation of AB-8 is 0.75 g(crude drug)/mL(macroporous resins),the best elution reagent is 50%EtoH and it‘s eluation ration is 68.81%.The saturation of D-101 is 0.75 g(crude drug)/mL(macroporous resins),the best elution reagent is 60%EtoH and it‘s eluation ration is 64.67%.The saturation of H-103 is 0.5 g(crude drug)/mL(macroporous resins),the best elution reagent is 50%EtoH and it‘s elution ration is 51.18%.Conclusion: AB-8 and D-101 are the superior absorbents for glycyrrhizic acid.

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