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期 刊 ：中国中药杂志 2007年 32卷 16期 页码：1700.

关键词：十八反；海藻；甘草；毒理学；

Keywords:18 counter, Sargassum, Radix Glycyrrhizae, toxicology,

摘 要 ：目的：研究不同比例海藻与甘草配伍对大鼠的毒性作用。方法：32只Wistar大鼠,体重(123±15.3) g,随机分为4组,每组各8只,分别为 正常组(A)和配伍用药组(B,C,D)。正常组用蒸馏水灌胃,B,C,D组用海藻-甘草(1∶1)、海藻-甘草(2∶1)、甘草-海藻(3∶1)灌胃,给药剂量为生 药20 mg·g^-1体重,共35 d,期间观察大鼠的毛色、进食、活动等情况。第36天处死大鼠,对大鼠体重,脏器系数,血常规,血液生化指 标及肝药酶进行检测。结果：海藻与甘草配伍对大鼠毛色、进食、活动、体重、脏器系数无影响,对血液系统、肝功能、心肌酶、肾功能、肝药 酶会产生一定的影响,且与配伍比例有关。结论：海藻甘草不同比例配伍后,对大鼠脏器具有选择毒性作用,并与配伍比例有关。

Abstract:Objective: Study the toxicity effect of different rate of Sargassum and Radix Glycyrrhizae on rats. Method: 32 Wistar rats ［body weight (123±15.3) g ］ were random divided into 4 groups of 8: normal group (A) and compatibility medicine group (B, C, D). The normal group was oral administrated with the distilled water, B, C, D group were oral given the Sargassum and Radix Glycyrrhizae (1∶1), Sargassum and Radix Glycyrrhizae (1∶2), Sargassum and Radix Glycyrrhizae (1∶3) for 35 days, the dose was 20 mg·g^-1 weight, in the meantime, general state of health was observed, then rats were slaughtered, and the body weight, internal organs coefficient, blood routine, serum biochemistry and liver drug enzyme were assaied. Result: The rats’ general state of health, body weight, internal organs coefficient has not been affected, the hemoglobin, the red blood cell, the kidney function and liver function have been affected, and has some toxic effect on the rats‘s white blood cell and cardic muscle, the toxic effect on cardic muscle was increase along with the rate of Sargassum and Radix Glycyrrhizae; liver drug enzyme activity has been improved. Conclusion: The different rates of Sargassum and Radix Glycyrrhizae have some selective toxic effect on internal organs of rats.

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