Effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal,estrogen-treated and postpartum mice
Abstract:Objective: To investigate the effects of different concentration extract from Shenghua decoction on contractile activity of the uterine smooth muscle isolated from normal, estrogen-treated and postpartum mice.Method: Medlab/4 s vital signal recorder was used to measure the effects of extract from Shenghua decoction(3-12 mg·mL-1) on contractile amplitude and frequency of the isolated uterus from normal,estrogen-treated and postpartum mice.Result: Shenghua decoction extract(3-12 mg·mL-1) significantly decreased the contractile activity of the mouse isolated uterus in normal non-pregnancy and postpartum,but significantly increased that of the mouse isolated uterus treated with estrogen,and didn‘t show significant concentration-response relationship.Conclusion: The effects of Shenghua decoction extract on contractile activity of mouse-isolated uterus treated with estrogen cannot represent the pharmacological effects on that of in normal non-pregnancy and postpartum uterus.