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期 刊 ：中国中药杂志 1999年 24卷 03期 页码：166.

关键词：青蒿提取物；青蒿素；内毒素；

Keywords:Artemisia annua, qinghaosu, endotoxin,

摘 要 ：目的：探讨青蒿提取物抗内毒素作用。方法：测定大鼠肝线粒体ＬＰＯ、溶酶体ＡＣＰ、血浆内毒素和ＴＮＦα、肝微粒体Ｐ_４５０浓度、肝线粒体ＳＯＤ活性，观察小鼠死亡率和组织形态。结果：青蒿提取物、青蒿素可降低ＬＰＯ，ＡＣＰ，内毒素，ＴＮＦα，Ｐ_４５０浓度，升高ＳＯＤ活性，降低内毒素休克小鼠的死亡率，延长小鼠的平均生存时间，对肝、肺组织形态也有一定的保护作用。结论：青蒿提取物具有抗内毒素作用。

Abstract:Objective:To explore the antiendotoxin effect of extracts from Artemisia annua(AA) and qinghaosu(QHS).Method:LPO and SOD in chondriosome,ACP in lysosomes,tumor nicrosis factor α(TNF α) and endotoxin in plasma,and P 450 concentration in hepatic microsome of rats were determined.Mortality of endotoxemic mice and histomorphology were observed.Result:LPO,ACP,endotoxin,TNF α and P ₄₅₀ content were decreased with AA and QHS.SOD activity was increased with AA and QHS.At the same time,mortality was decreased.Histomorphology of lysosomes and chondriosome of rats were protected from endotoxin.Conclusion:AA and QHS possess an antiendotoxin effect .

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