Abstract:Crebanine (Cre) iv 5mg/kg could eonvert BaCl2-induced arrhythmia into sinus rhythm in rats, and could significantly increase the tolerant dose of aconitine to produce ventrieular fibrillation(VF) and cardiac arrest (CA) in rata. The drug could also decrease the incidence of VF and CA by CaCl2 in rats and by chloroform in mice, but had no proteetive effects on ouahain-indueed arrhythmias in guinea pigs.