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期 刊 ：中国中药杂志 1995年 20卷 02期 页码：92.

关键词：秦皮；秦皮甲素；直肠给药；生物利用度；改良离体外翻肠囊法；

Keywords:ash bark, aesculin, rectal administration, bioavailability, medified isolated rectum-bag method,

摘 要 ：以血清中秦皮甲素薄层斑点扫描积分值为指标,采用正交设计,找出秦皮直肠给药的最佳条件。再以秦皮口服和直肠给药后生物利用度比较,表明直肠给药更优。应用改良离体外翻肠囊法进行秦皮直肠给药的体外实验,结果与体内实验一致。

Abstract:A TLC-densitometric methed was applied to determine aesculin in rabbit blood. The best way for ash bark rectaladministration was found by orthogonal design[L₄(2³)].The two routes of administration(per rectal,P. O) were com-pared by bioavailabilities and the result indicated that per rectal was better than P.O. Modified isolated rectum-bagmethed was applied successfully to finding the best way for rectal administration of ash bark.

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