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期 刊 ：中国中药杂志 1990年 15卷 07期 页码：49.

关键词：糖尿病；山梨醇代谢通路；醛糖还原酶抑制剂；中草药；

Keywords:diabetes mellitus, sorbiool pathway, aldose reductase inhibitor, Chinese materia medica,

摘 要 ：应用黄芩甙150mg/kg.d及甘草流浸膏7.5ml/kg.d分别灌胃治疗病程两周的糖尿病大鼠模型1周,发现治疗前后糖尿病鼠的血糖水平无明显下降,但红细胞山梨醇含量于治疗后显著降低,提示两药在动物体内也有醛糖还原酶抑制作用,有可能用于糖尿病慢性并发症的防治。

Abstract:10 streptozotocin-induced diabetic rats were treated with baicalin 150mg/kg·d and liquid extract of licorlce(LEL) 7.5ml/kg·d (5 by each medicine) for a week. The results indicated that orally baicaliu and LEL could dramatically reduce the sorbitol levels in red blood cells(123.7±28.6 to 72.5±21.8 and 116.9±25.2 to 80.5±23.8nmol/g·Hb, respectively) without affecting blood glucose levels significantly. It is suggested that both medicines act by inhibiting aldose reductase.

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