Abstract:The experimental results have shown that the toxicity of variously processed Phytolacca americana is lower than that of the original rude drug, i.e. the local irritability tends to decrease by 16.7~83.3%; LD50 to elevate by 1.66~10.47 times;expectoration to increase by 1.10~1.57 times;but diuresis mostly to decrease by 16.0~45.0%.This reveals that the main object of processing Phylolacca americana is to lower toxicity, increase expectoration and relive diuresis to reduce fluid retention.