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期 刊 ：中国中药杂志 1990年 15卷 05期 页码：48.

关键词：蛇床子总香豆素；支气管；止喘；β-受体；心得安；

Keywords:total coumarins in the fruit of Cnidium monnieri, bronchus, antiasthmatic, β-receptor, propranolol,

摘 要 ：蛇床子总香豆素具有松驰由药物引起的支气管痉挛和直接扩张支气管的作用,这一作用均能被β-受体阻滞剂心得安所阻断。此外,蛇床子总香豆素对麻醉动物无加快心率和升高血压的作用。提示蛇床子总香豆素的解痉作用可能是通过兴奋β₂-受体所致。

Abstract:Total coumarins in the fruit of Cnidium monnieri show a marked protective effect against hronchial asthma induced by inhalation of histamine in conscious guinea pig. In vitro these total coumarins can relax the contraction of the isolated trachea in guinea pigs induced by histamine as well as increase the perfusion rate of isolated lung preparation of guinea pig. These actions, however, may be bloeked by propranolol. Besides, these coumarins cannot increase the heart rate and arterial blood pressure in anesthetized rats. All this shows that the antiasthmatic effect of total coumarins in the fruit of Cnidium monnieri is mediated by β₂-receptor.

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