采用人工污染土壤法测定了不同浓度阿苯哒唑对蚯蚓生长、生存、繁殖以及超氧化物歧化酶（SOD）、谷胱甘肽-硫转移酶（GST-S）、乙酰胆碱酯酶（AchE）活性的影响.结果表明:低浓度阿苯哒唑（5 mg·kg-1）对蚯蚓的繁殖有显著的抑制作用（P<0.05）；当阿苯哒唑含量达到7 mg·kg-1时，将明显影响蚯蚓的生长和生存（P<0.05）;当其含量达到10 mg·kg-1时,蚯蚓的死亡率为53%.阿苯哒唑浓度与蚯蚓的生长、繁殖间存在明显的剂-效关系.阿苯哒唑染毒21 d后,对蚯蚓SOD、GST-S的活性有明显影响,药物浓度与效应间没有明显的剂-效关系，对AchE活性没有表现出明显的影响.阿苯哒唑对土壤动物显示毒性作用,具有潜在的生态风险.
By using artificial soil test, the effects of different concentration
albendozole on Eisenia foetida’s growth, survival, reproduction, and activities
of superoxide dismutase (SOD), glutathione-sulfurtransferase (GST-S) and acet
ylcholine esterase (AchE) were studied. Low concentration (5 mg·kg-1) albe
ndazole inhibited the reproduction of E. foetida significantly (P<005), an
d 7 mg·kg-1 of albendazole had significant effects on the growth and surv
ival of E. foetida. When the albendazole concentration reached to 10 mg·kg
-1, the mortality of E. foetida was as high as 53%. There was a signif
icant dose-response relationship between the exposure concentration of albendaz
ole and the inhibition rate of E. foetida’s growth and reproduction. After
21 days’ albendazole exposure, the SOD and GST-S activities were affected sign
ificantly, but no significant dose-response relationship was observed. Albendaz
ole exposure had less effects on AchE activity. In sum, albendazole had direct
toxicity on soil animals, with a potential ecological risk.