Abstract:7,8-dihydroxyflavone (7,8-DHF) is a kind of flavonoids. In recent years, 7,8-DHF has been confirmed to be the specific agonist of tyrosine kinase B (TrkB) receptor, which can activate TrkB receptors and play an important role in nerve protection. Moreover, 7,8-DHF has other functions, such as antioxidant, anti-inflammation and cardiovascular regulation, and so on. In this paper, the physiological functions of 7,8-DHF are reviewed.