Abstract:Stem cell and regenerative medicine is the flourishing subject in this century. The construction of artificial tissue and organs is the significant content of stem cell and regenerative medicine research， which has strategic importance for solving many problems existing in population health in China. The Chinese Academy of Sciences deployed in advance the Strategic Priority Research Program of “Stem Cell and Regenerative Medicine” in 2011，and designed the project “The Construction of Artificial Tissue and Organs” for achieving the translation work in this field. The intelligent biomaterials capable of inducing tissue regeneration is the major mission of this project. Here we summarize the major advances of two original intelligent biomaterials for tissue regeneration.