Abstract:Spatial variability and management zone of tobacco soil nutrients in Qiannan Karst mountainous area were analyzed using geostatistics and fuzzy c-means cluster, Guizhou province. Results indicated that soils were weak acidic in general. A very small part of soils were short of OM, AN, AP, ACu and AZn; a small part of soils were short of AK, ECa and EMg; most of soils were short of AMo. Soil pH, OM, AN, AP, AK, EMg, ACu, AZn and AMo displayed moderate spatial autocorrelation, and ECa displayed weak spatial autocorrelation. Spatial variability of pH, OM, AN, AP, AK, ECa, EMg and AZn were mainly caused by random factors, ACu and AMo were mainly caused by structural factors. Soil nutrients displayed spatial obvious trend effect. Soil pH, AP, AK, ECa, EMg, ACu, AZn and AMo showed decreasing distribution from several high centers to surroundings. OM and AN showed increasing distribution from north, west, south to midland and east. Study area was divided into four management zones (MZs). soil nutrients content tended to be homogeneous in each management zone and significantly different among management zones. This findings will provide references for farmland soil nutrients management, crop balanced fertilization, and fertilization efficiency in Karst mountainous area.