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作 者 ：曾艳波，梅文莉，庄令，洪葵，戴好富

期 刊 ：热带亚热带植物学报 2007年 15卷 3期 页码：249~252

关键词：瓶花木；化学成分；细胞毒活性；MTT；SMMC-7721；

Keywords:Scyphiphora hydrophyllacea, Chemical constituent, Cytotoxic activity, MTT, SMMC-7721,

摘 要 ：从红树林植物瓶花木 (Scyphiphora hydrophyllacea Gaertn. F.) 的乙醇提取物中分离得到6个化合物，经波谱分析及与文献数据对照确定其结构分别为：betulone (1)、3,4,5-三甲氧基苯酚-β-D-吡喃葡萄糖苷(2)、α-香树脂醇(3)、β-香树脂醇(4)、β-谷甾醇(5)和豆甾醇(6)。经MTT法测定以上化合物的肝癌细胞毒活性，结果表明化合物1对肝癌细胞SMMC-7721的增殖显示生长抑制活性，其IC₅₀值为12.5 μg ml^-1。

Abstract:Six compounds were isolated from the ethanol extract of mangrove plant Scyphiphora hydrophyllacea Gaertn. F. Their structures were identified as betulone (1), 3,4,5-trimethoxyphenol-β-D-glucopyranoside (2), α-amyrin (3), β-amyrin (4), β-sitosterol (5), and stigmasterol (6) by spectroscopic evidence (IR, NMR, MS, etc.) and comparision of their spectral data with those of the literatures. The cytotoxicty of all the compounds were tested by MTT assay, and compound 1 showed inhibitory activity towards human hepatoma cellline SMMC-7721 with the IC₅₀ value of 12.5 μg ml^-1.

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