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作 者 ：马永婷;骆浩;李双明;李政楠;付玉杰;*

期 刊 ：植物研究 2009年 29卷 5期 页码：637-640

关键词：异甘草素；合成；工艺优化；

Keywords:isoliquiritigenin, synthesis, optimization of conditions,

摘 要 ：以2，4-二羟基苯乙酮和对羟基苯甲醛为原料，通过羟基保护，羟醛缩合及脱保护合成得到了异甘草素。并对其中的关键步骤羟醛缩合反应条件如：催化剂的种类，底物的摩尔比，反应温度，溶剂以及反应时间进行了优化。结果表明，在以Ba(OH)₂为催化剂，甲醇为反应溶剂，对羟基苯甲醛和2，4-二羟基苯乙酮的摩尔比为1.8∶1，温度为45℃的条件下，反应12 h，羟醛缩合反应的收率最高（77.9%），且体系较为简单，易于纯化。

Abstract:Isoliquiritigenin was synthesized with 2,4-Dihydroxyacetophenone and 4Hydroxybenzaldehyde as the starting materials by protecting of hydroxy, Aldol Addition and deprotecting. The reaction conditions of the key step-Aldol Addition, including catalyst, ratio of substrates, temperature, solvent and time were optimized. Results showed that the optimal condition of the key step were as follows: catalyst Ba(OH)₂, solvent MeOH, M(4-Hydroxybenzaldehyde):M(2,4-Dihydroxyacetophenone)=1.8∶1, tempetature 45℃, and time 12 h. Under the optimal conditions, the yield of the reaction achieved the highest(77.9%). In addition, the reaction system was simple and easily purified.

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