免费文献传递   相关文献

Effects of Alfalfa Flavonoids on the Gene Expression of Hypothalamus-Pituitary- Ovarian Gonadal Axis in the Preadolescence and Maturity of Female Rat

苜蓿总黄酮对未达性成熟期及成年雌性大鼠下丘脑-垂体-卵巢性腺轴相关基因表达量的影响



全 文 :!!!
"
!
!
"
#
!
#$%&!!
!
$&"
!
!
"
!
#
!
$
()*( (+,-.*/( .//)(
!!!
012
$
!
3
%
!
45
6
&
!!
!012
!"#
!
10&117""
"
8
&9::;&1007<02"3&!012&0"&0!2
ÁÂÇÛV`WÓ2nûZ[
L

L
]^2_`,-In‚Óì+lm
!
!
¬
1
#
!¤
!
#
ûPP
1
#
‘·¥
1
#
R*ã
1
#
!/
1
#
‡¶L
1
#
$
1&
_Åæç*+Fý“+É
#
_Å mö
23000!

!&
_Åæç*+v;<Ôl
$
Ø}
%

#
_Å mö
23000!
%
CDEF
!
01"<0X<0!

GHEF
!
01"<11<1X
IJKL
!
ëÝ
,
œŒÝ
-
.ÔÕÖd×
$
!011\(@17\02
%
_ŀۑ£$Kí
$
1121003100!!
%
ëÝF,4çÔls)
$
;
6
I
6
DT<"3
%
î«
MNOP
!
ï2
$
1X=3<
%#
ò
#
_Åmö÷
#
áŒ/04
#
/0ù¤²F,~
#
-!
UUA9=3
!
1!>&I$K

#
-â,¥
(EDJ$GF$GI$GGA:
S
$;<
HA;IA
#
-!
6
TOO
8
VV
!
1>"&I$K
34
!
²/0ËÌ
$
=,/*3"
8
2("#*-"
%
ÚòDkléªP¾Ž#r¾$#Šf!
<
1s
<
<=P>[fKWª…
Hjk
#
qþP*?²nükl
#

3
JF<Ÿ
!
"
JËÌÚò@…Ÿ
$
1!0
#
200
#
1!00K
C
/
W
C
f1
%
ã
!
JD5Ÿ
$
@‡þ·
0&3K
C
/
W
C
f1
)
)äD5Ÿ
%(
¸¹Ë
!
éªP¾Ž#þ?G
)
S@…Ÿã@‡þ·ŸþP>éN^E
éN
$
I+>S
%
ª…Ì`0Á
$
:
$
0&03
%
Á@…ËÌÚòŸþÚs4¾N
$
!S
%
ª…Ì`SmS@…Ÿ
$
:
$
0&03
%
5<=GËÌÚòS@…Ÿþ<-4¾N‚s
$
T@S>
%
ª…8Ì`øS
$
:
$
0&01
%
¶i¼›
$
PZ:1X14
1
%
€ËÌÚòÁ@…Ÿª…8Ì`øS
11
Ä
$
:
$
0&01
%#
€@‡þ·ŸÌ`øS
=
Ä
$
:
$
0&03
%(
¾$*?Ë
ÌÚò
"
J@…Ÿã@‡þ·ŸH
I+>S
ª…Ì`0Á
$
:
$
0&03
%
Á@…ËÌÚòHþÚs4¾N‚s
$
!S>
%
ª…8Ì`øS
>
Ä
$
:
$
0&01
%#
PZ:1X141
ª…`)äD5ÌS
=
Ä
$
:
$
0&03
%(
ËÌÚòD¦4
}{|þ?jkJ[¦
#
iß-»Šf!
<
1s
<
<=P>44?ŸÿÏê
#
_-»?ŸÿÏêÌ`n‡Z
I+4
>S
Hª
#
}Ëjkþ?P>G5l[fKWHª…
(
-56
!
ËÌÚò

Šf!
<
1s
<
<=P>

*?

N#ž…
789:;
!
.=12&1
!!!!!
<=>?@
!
(
!!!!!
!
1007<02"3
$
!012
%
0"<0>00<03
5..,&(".:6.26.2D62F")"#!(")&*1)5T
-
0((#")".Q
7-
"&*2629H(L/#&H#&20
7
L
GF20#2)1")2!26:T#(#)&*/02!"6(,),2)!82&H0#&
7
".D926B2&
?(+?A9
1
#
?(+RA;
C
<
6
E;
!
#
*/(495$1
#
_[(+[$;
C
1
#
B/(+c9;<
S
9;
C
1
#
?(+)JA;
C
C
1
#
](cEAC
1
#
$
1&)$%A
C
A$F(;9K5%[E:O5;HG
6
5;H#ADAG9;5G
6
.I9A;IA
#
[A;5;(
C
G9IE%DEG5%L;9MAG:9D
6
#
_JA;
C
VJ$E
#
[A;5;QG$M9;IA23000!
#
)J9;5

!&)A;DAG$F4$HAG;-T
S
AG9KA;D5;H45;5
C
AKA;D
#
[A;5;(
C
G9IE%DEG5%L;9MAG:9D
6
#
_JA;
C
VJ$E
#
[A;5;QG$M9;IA23000!
#
)J9;5
%
:;(&02,&
!
*JA9K
S
5ID:$F5%F5%F5F%5M$;$9H:$;DJA
C
A;AAT
S
GA::9$;$FJ
6S
$DJ5%5KE:<
S
9DE9D5G
6
<$M5G95;
C
$<
;5H5%5T9:9;DJA
S
GA5H$%A:IA;IA5;HK5DEG9D
6
$F5;9K5%UAGA9;MA:D9
C
5DAH&*JGAAH$:A:$F5%F5%F5F%5M$;$9H:
$
1!0
#
200
#
1!00K
C
/
W
C
f1
%
5;HDU$I$;DG$%
C
G$E
S
:
$
H9ADJ
6
%:D9%OA:DG$%0&3K
C
/
W
C
f1
I$;DG$%
C
G$E
S
%
UAGA
HA:9
C
;AH9;DJ9:AT
S
AG9KA;D&,A:E%D::J$UAHDJ5DDJAAT
S
GA::9$;$FI+>SU5::9
C
;9F9I5;D%
6
GAHEIAHO
6
DJA
K9HH%A5;HJ9
C
JH$:A:$F5%F5%F5F%5M$;$9H:5;HH9ADJ
6
%:D9%OA:DG$%9;DJA
S
GA5H$%A:IA;D$FG5D
$
:
$
0&03
%
&
*JAAT
S
GA::9$;$F!SU5::9
C
;9F9I5;D%
6
9;IGA5:AHO
6
5%F5%F5F%5M$;$9H:9;%$UH$:ADGA5DKA;DI$K
S
5GAHU9DJ
DJ5D9;J9
C
JH$:ADGA5DKA;D
$
:
$
0&03
%#
UJAGA5:DJAAT
S
GA::9$;$FT@S>U5::9
C
;9F9I5;D%
6
9;IGA5:AHO
6
5%<
F5%F5F%5M$;$9H:9;J9
C
JH$:ADGA5DKA;D
$
:
$
0&01
%
&*JAAT
S
GA::9$;$FPZ:1X141U5::9
C
;9F9I5;D%
6
9;<
IGA5:AH11D9KA:O
6
5%F5%F5F%5M$;$9H:9;%$UH$:ADGA5DKA;D
$
:
$
0&01
%#
5;HU5::9
C
;9F9I5;D%
6
9;IGA5:AH=
D9KA:O
6
H9ADJ
6
%:D9%OA:DG$%
$
:
$
0&03
%
&*JAAT
S
GA::9$;$FI+>S9;J
6S
$DJ5%5KE:U5::9
C
;9F9I5;D%
6
GAHEIAH
O
6
5%F5%F5F%5M$;$9H:5;HH9ADJ
6
%:D9%OA:DG$%9;K5DEGAG5D
$
:
$
0&03
%
&*JAAT
S
GA::9$;$F!S>U5::9
C
;9F9<
I5;D%
6
9;IGA5:AH>D9KA:O
6
5%F5%F5F%5M$;$9H:9;%$UH$:A:
C
G$E
S
$
:
$
0&01
%
&*JAAT
S
GA::9$;$FPZ:1X141
U5::9
C
;9F9I5;D9;IGA5:AH=D9KA:O
6
5%F5%F5F%5M$;$9H:9;%$UH$:A:
C
G$E
S
$
:
$
0&03
%
&*JAGAF$GA
#
DJA9K<
S
5ID:$F5%F5%F5F%5M$;$9H:J5HH9FFAGA;DAFFAID:$;
C
A;AAT
S
GA::9$;5K$;
C
DJAH9FFAGA;DHAMA%$
S
KA;D5%:D5
C
A:
$FG5D&*JAAT
S
GA::9$;$FI+>S U5::9
C
;9F9I5;D%
6
GAHEIAHO
6
DJA;A
C
5D9MAFAAHO5IW$FJ
6S
$DJ5%5KE:<
S
9DE9<
!"
# ï
!
2W
!
ËÌ~ÚòDéªP¾Ž#r¾$þP*?Šf!
<
1s
<
<=P>[fKWª…Hjk
D5G
6
<$M5G95;
C
$;5H5%5T9:
#
UJ9IJDJA;9;F%EA;IAH$DJAG
C
A;AAT
S
GA::9$;:&
<
7
="0!(
!
(%F5%F5F%5M$;$9H:

[
6S
$DJ5%5KE:<
S
9DE9D5G
6
<$M5G95;
C
$;5H5%5T9:

RAK5%AG5D

bQ),
!!
“«Ž[$ÉÊËÌ
$
=,/*3"
8
2("#*-"
%
ہAk
lGHÕÖª«–Í
#
ÖËÌDBH!¾Ô¹xyÌ

#
WX
#
DËÌiLM€ÅAklG44[Õ,Ö
#
pbi€»ÆPœù]CúZq*+¥HLC
(
ËË
ÌG4läP¾aH/0ãÕÖ|ª«CúZ÷HH

*
1
+
(
êZë©õ+¥DÉÊËÌH67¼+¾3
>ºPž
#
67uvÚò
)
DE
)
iÜNŽ
)
ÍL
)
œK

)
*
!
+
(
ËÌÚòiÉÊËÌHI4l
äP¾a
#
êZ(s¸*Èqa²Úòr+Ž
)
Úòh
r+Ž
)
•ÚòŽ
)
Œ–ÚòW
*
"
+
(
ÚòŽ¼ýlH6
74l+pPwi2lþéN,Ö
#
DþéN
,ÖȜÅjk„%ÞHPéN
)
/<
)
nFHºäW
WN
#
÷Hq€F,´GHFâGz
#
%ؑH
’ýIȜTOA»ÍHô•ÚòŽH=JÊNM›
8
$
U&*
9
27*5
.
"&#,+(,
%
˜f
*
2
+
(
2lþéNH,ÖE‡ÕÇãþéNH,ÖE‡

(
/0Ë
#
þéN©Ââ&½ùü˜
!

*
3
+
#
Iiƒ]kHŽühâx®

)IiŠ]kH
Žühâx®
(
êZèÉHºÁþéNÏ5E‡i
þéNXA©Â§T5ƒ©H‚s
$
G>

ã
G>
&
%
¸
ý
#
z4*¿H("½¾Œps
#
c§´TKKWGH
þéNÕB<‰¸ý
#
]kKWH&®ãêL
(
2l
þéNãþéNߘ·#¸*
(
WXÇ23GH
G>

ã
G>
&
D
!
J‚scÈã2lþéN¸ý
(
iTþé
N[`ãÇ[DÀQ
*
>
+
(
G°i™šKWŸHÏ5
ùü
#
Xõª˜$KWŸ23
#
·-»€8*¸Á©”
ú#
w_Š¾Ï5
*
7
+
(
2lþéNªœ-»n‡I[›HäP
#
€÷s
Œkls©44[ÕH4},Ö
(
/0z
#
ÚòŽ
¼ýlÈqn‡Mœãäé›
$
Q*N
%
ãN•*›
*
#
ËD
!
›T
@(
H&®
)
9‡qr©ÂaD˜
f
(
)˜+¥/0ɲ
#
ÚòŽ¼ýlDþéNý¾
Hfc›¶i¼›Hn‡
#
ã&>O©ÂH–Æ‚„
n‡˜f
(

#
ÚòH2lþéN,Ö
#
ªÈqã
SƒéN‚sÖÝjH»G¼l›–Æséä‚s
$
::1>
%
H
"
JÏ¿
$
::1>

#
::1>
(
ã
::1>
)
%
,
Ö͍vç
*
=
+
(
WX
#
BCfJ-»ËÌÚòDŠf
!
<
1s
<
<=P>H/0
#
DËÌÚòjk4Æ)*
H»“˜XIšHZ¬
(
>
!
½¾&¿À
>&>
!
IJXY&½¾
.QR
‹
>3
à†
.@
þ?
73
<
)
!1
à†þ?
!3
<
#
Æ_ŀ;(
þ?nƒOP
G
#
=Ò5‡€
1=
#
!!d
#
KV€
20e
#
70e
#
#5
¸Á
12J
#
"
10J
è
(
F<#²
!01!
$
X
&
1!
%
#
€_Åæç*+,ç.+;<=XY
(
ËÌ~Úò
xV
"3e
#
ÆuzãQ4l“˜†è¼44
(
@
‡þ·ÆýðÎc‡9˜†è¼44
(
>&?
!
IJ9H
Ó
>3
à†þ?a²
3
Ÿ
#
¼Ÿ
13
<
#
¼<*?,²
1
J99
#
ab‡H)äD5Ÿ
)
ËÌÚò
1!0
K
C
/
W
C
f1
)
ËÌÚò
200K
C
/
W
C
f1
)
ËÌÚò
1!00
K
C
/
W
C
f1
)
@‡þ·
0&3K
C
/
W
C
f1
*
X
+

(¶zA
!=H
(
!1
à†þ?a²
3
Ÿ
#
¼<*?,²
1
J99

¼Ÿ
3
<
#
ab²)äD5Ÿ
)
ËÌÚò
1!0K
C
/
W
C
f1
)
ËÌÚò
200K
C
/
W
C
f1
)
ËÌÚò
1!00K
C
/
W
C
f1
)
@‡þ·
0&3
K
C
/
W
C
f1

(¶zA
12H
(
¼<*?zA
!KB
(
>&@
!
´+3¢&Ð*
!
oF<*?€zA¸À§
#
7O
1H
Óþ?‹9
¦®§
#
¼Ÿ“Eù
3
<*?
#
Ɋf!
)
1s
)
<=Ÿ
 ±F
#
_w_EA1ÇG
#
c§€
f=0d
¸ýGú
(
>&A
!
y4Iaƒb
*,/V$%
ƒÌÉF@Æ®4l
$
*(
%
˜†è
¼Š~

%^9
C
$
$
HD
%
1=QG9KAG
)
H*Q
ý@
)
,5:A
4<4B#
)
,5:A
n‡@
)
3Z4<4B#\EFFAG
Šn®
4l
$
*(
%
˜†è¼

@-Q*

.]\,
`
Q),49T
Šn&#R
$
Go
%
4l.Ԙ†è¼

N#ž…
Q),
þŠnHBðGëè¼

\üS_„E
ŠnHBðGëè¼

@]]<=)
¿fd‡ÑŠn
»‚§Iþ±=

fd«¬¾uab)*Šn‰ë
.]+--
è¼

5;$HG$
S
!000
"
!000)
a##V
d@n
*JAGK$:I9A;D9F9I
(
>&W
!
ûZ[
<

<
]^2_`,-In‚Óì+
\S
Ö
*,/V$%
ƒÌÉF@ÌɊf!
)
1s
)
<=
Ÿ ~
,(
#
›ž
,(
Oô…rSV
#
@^
â€
1&=
#
!&0

#
ˆ7aâ4l+F<7Ô
(
€
)\/
GYõþP>éN^EéN
I+>S
)
þ<-4¾N
T@S
)
þÚs4¾N
!S
)
þ<-4¾N‚s
T@S>
)
10>
!!
"
!
#
!
$
!
!!
"
þÚs4¾N‚s
!S>
)
¶i¼›
PZ:1X11
ã#ò
>+
31=:
KWӓ
(
”Ö
QG9KAGQGAK9AG3&0
•
‰‡d[ÕCl
(
Æ»§ýZ*KW.Ԙ†è
¼ý¾
#
q
+(@Q[
²©z—s”ìL
1

(
Ÿ
&®s)
!
~ŸÕs)
!0
$
B
#

-Q
ØG—A~
,(10
$
B
)
%^9
C
$
$
HD
%
1=QG9KAG1
$
B
)
@-Q)
G
1
$
B
ý1
#
70d
ÃÒ
10K9;
w_€¸G#ï
!K9;
q
G
#
³„{S
(
€ÓG°ŸÕ1G—A
3Z4<4B#
\EFAG2
$
B
)
H*Q
ý@
0&3
$
B
)
,5:A4<4B#1
$
B
)
,5:A
n‡@
0&!3
$
B
)
@-Q)
G
!&!3
$
B
#
2!d
ÃÒ
1J
#
70d
ÃÒ
13K9;
§¸Gïb
#
·g„
I@(
EA
f!0d
¸ýGú
(
ªab’Ö[D;¸N
#ž…
Q),
›ž
#
,A5%*9KAQ),
ŸÕˆ‰²
!
X3d
!K9;
#
X3d!0:
#
>0d!0:
#
7!d!0:
#
ú
20
J"#
(
‚
>
!
Y*M
*5O%A1
!
%^9
C
$;EI%A$D9HA
S
G9KAG:
KW»‹
+A;A;5KA
ӓ
.A
`
EA;IA
4l
QG$HEIA:9VA
"
O
S
I+>S
3o(((*++)(+(())))(+(()"o
3o((*+)++((+)))()()((*"o
!12
!S
3o+)(*)())**)())())(+)(*"o
3o*++**(+(()())*+)*++)*)"o
!=1
T@S
3o(*))*()*)*++*+)**+("o
3o***)*+++*+***++*)*("o
17X
!S>
3o)****()((())*)))*)+"o
3o()(+()*)+**(**)(*)))*"o
17=
T@S>
3o((()(*))()(*)+**+))"o
3o+**)(*)*(+)*+(+**))+*"o
1!=
PZ:1X141
3o)*+()(()*)+++)*()+"
3o(+*+)**+))(++)(**("o
123
31=:
3o++**+))*)*(+))+***)"o
3o+++(+*(*)*+++*))*)(*)"o
131
I1D:S
3o()(*)((+((++*++*+((+)(+"o
3o*)(((++*++((+((*+++(+**"o
11=
>&P
!
¼ïÐ*
’Ö
.Q..1"&0
ab•‰XY{s}
(
ÅW
Nù”ab
)
{s[fab¸¹’Ö\c{
q
=O
”
$
KA5;q.@
%
±
(
?
!
aÍ&9Î
?&>
!
ÁÂÇÛV`nè}Y2_`,-In‚Ó
ì+lm
T)äD5Ÿ[`
#
¾$*?ËÌÚò
"
J@
…Ÿã@‡þ·ŸHþP>éN^EéN
$
I+>S
%
ã
!S
ª…Ì`0Á
$
:
$
0&03
%#
R.[
ª…|
‚„IžHn‡
$
:
%
0&03
%(
¾$*?<=GJF
<ŸcÁ
#
þ<-4¾N‚s
$
T@S>
%
Hª…”
•Ì`
#
iª…cÁm)äD5Ÿ
(
ËËÌÚ
ò
"
J@…Ÿ5þÚs4¾N‚s
!S>
Hª…
mcSm)äD5Ÿ
$
:
%
0&03
%#
fÁ@…ŸH
ª…8Ì`øS
>
Ä
$
:
$
0&01
%(
¾$*?ËÌÚ
òJ@…Ÿ
#
<=GH#ò>+
31=:
Hª…
ã)äD5[`”•Ì`
#
iã@‡þ·Ÿ[`
#
31=:
Hª…Š0
#
fG
)
S@…Ÿqr)äD5
Ÿª…8Ì`0Á
$
:
$
0&01
%(
©Â¾N
Q230
¶i¼›ikls©þéNý¾Hfc›
#
¾$*
?ËÌÚòÁ@…Ÿ
#
<=G
PZ:1X141
Hª…
`)äD5ŸÌS
=
Ä
$
:
$
0&03
%#
5lJŸ|ß
Sm)äD5
$
:
%
0&03
%(
?&?
!
ÁÂÇÛV`WÓ2nIn‚Óì+lm
éªP¾Ž#HG
)
S@…Ÿã@‡þ·Ÿ
I+>S
ª…Ì`0Á
$
:
$
0&03
%(
éªP¾Ž#
*?1s
T@S
ª…|º€Ì`P”•
#

ª…ã)äD5Ÿ`c˜Gø
(
DmÁ@…ËÌÚ
òŸ
!S
ª…Ì`SmS@…Ÿ
$
:
$
0&03
%#
ã
)äD5[`”•Ì`
(
éªP¾Ž#*?
T@S>
ª…ã)äD5`˜1øS
$
:
%
0&03
%#
fËÌÚòS@Ÿ8Ì`øS
$
:
$
0&01
%#
!S>
H
ª…T)äD5[`˜1øS
#
i”•cÌ`
(
éªP¾Ž#*?<=G
PZ:1X141
Hª…€
JF#
5GËÌÚòÁ@…
ª…8Ì`øS
11
Ä
$
:
$
0&01
%#
@‡þ·ŸÌ`
øS
=
Ä
$
:
$
0&03
%(
!0>
!"
# ï
!
2W
!
ËÌ~ÚòDéªP¾Ž#r¾$þP*?Šf!
<
1s
<
<=P>[fKWª…Hjk
‚
?
!
RaìHnè}Y2_`,-In‚Óì
*5O%A!
!
+A;AAT
S
GA::9$;:9;DJA
C
$;5H5%5T9:$FK5DEGAG5D:9;H9FFAGA;DH$A:
C
G$E
S
:
KW
!!
+A;A
!!
ËÌÚò
(%F5%F5F%5M$;$9H:
1!0K
C
/
W
C
f1
ËÌÚò
(%F5%F5F%5M$;$9H:
200K
C
/
W
C
f1
ËÌÚò
(%F5%F5F%5M$;$9H:
1!00K
C
/
W
C
f1
@‡þ·
@9ADJ
6
%:D9%OA:DG$%
0&3K
C
/
W
C
f1
)äD5
)$;DG$%
I+>S
0&17q0&07
O
0&13q0&1"
O
0&11q0&01
O
0&!>q0&12
O
1&11q1&0"
5
T@S
0&2>q0&""
5
0&>0q0&"3
5
1&31q0&!!
5
0&77q0&2>
5
1&00q0&7=
5
!S
0&33q0&1X
O
0&2Xq0&"3
O
0&32q0&1!
O
0&2Xq0&>0
O
1&01q0&!!
5
T@S>
0&2Xq0&17
5
0&>0q0&!0
5
0&!1q0&10
5
0&"7q0&1"
5
1&00q1&03
5
!S>
>&3"q"&"X
(
2&1Xq"&X"
5O
1&3>q0&"7
1&01q0&"2
1&0!q0&!!
PZ:1X141
=&!!q3&3=
5
>&">q3&!1
5O
"&"7q!&1!
5O
1&!=q0&30
O
1&1=q0&=3
O
31=:
1&==q0&=>
(1&0Xq1&00
1&1=q0&>0
"&!"q1&!2
(
1&0Xq0&33
!!
¬
!
¦Â#$%¥±”•Ì`
$
:
$
0&03
%#
¦*#$%¥±”•8Ì`
$
:
$
0&01
%#
Š¦
$DA
!
@9FFAGA;D:K5%%ADDAG:9;H9I5DA:9
C
;9F9I5;DH9FFAGA;IA5DDJA0&03%AMA%

H9FFAGA;DI5
S
9D5%%ADDAG:9;H9I5DA:9
C
;9F9I5;DH9FFAGA;IA5DDJA
0&01%AMA%
#
DJA:5KA5:OA%$U
‚
@
!
RaìHWÓ2n*5O%A"
!
+A;AAT
S
GA::9$;:9;DJA
C
$;5H5%5T9:$F9KK5DEGAG5D:9;H9FFAGA;DH$A:
C
G$E
S
:
KW
!!
+A;A
!!
ËÌÚò
(%F5%F5F%5M$;$9H:
1!0K
C
/
W
C
f1
ËÌÚò
(%F5%F5F%5M$;$9H:
200K
C
/
W
C
f1
ËÌÚò
(%F5%F5F%5M$;$9H:
1!00K
C
/
W
C
f1
@‡þ·
@9ADJ
6
%:D9%OA:DG$%
0&3K
/
W
C
f1
)äD5
)$;DG$%
I+>S
0&2!q0&0"
5O
0&!=q0&12
O
0&17q0&03
O
0&!0q0&1!
O
1&!!q0&X0
5
T@S
!&03q0&X7
5
1&3!q0&21
5
!&">q1&0"
5
!&21q1&13
5
1&07q0&2=
5
!S
1&X"q0&3!
5
1&"2q1&!3
5O
0&""q0&13
O
0&!7q0&!"
O
1&!0q0&7"
5O
T@S>
1&22q0&27
O
1&"7q0&1!
O
!&>!q0&=1
(5
1&"=q0&"!
O
1&00q0&0X
!S>
!&7"q!&"X
5
!&>7q1&2!
5
!&">q0&23
5
!&3=q1&2>
5
1&01q0&1X
5
PZ:1X141
11&2!q>&1"
(5
7&!Xq>&!>
5OI
!&"Xq1&=3
OI
=&7!q"&"1
5O
1&"1q1&13
)I
31=:
1&X2q1&>!
5
!&">q1&2!
5
"&07q1&1>
5
"&3Xq!&"0
5
1&1=q0&==
5
@
!
Ÿ 
¾$*?>ºXAP¾Ž¸#
#
5Šf!
<
1
s
<
<=P>
#
*¾ZIJŠìH4Æ©a%)
*
(

#
õùþéNHÌAYìŔšHa%
Ïê("
(
I+>S
,²P>HGªKW
#
DŠª
H1sã<=˜97HÏê,Ö
#
*@…H”Öþ
P>éN^EéNÈqn‡šH4Æz7
*
10
+
(
Ë<=a%HþéNWŽühéN
#
|ÈqŸ,Ö
mŠf!n‡þP>éN^EéNa%
(
BFËÌÚòn‡ZŠf!GHþP>éN^EéNH
a%
#
1ËËÌÚòHŽþéN,Ö44Z?Ÿÿ
Ïê
(
}<=GþéNý¾Hfc›
PZ:1X141
Hª…Sm)äD5Ÿ
#
pbiÁ@…HËÌÚ
ò
PZ:1X141
HªÌ`øSZ
=
Ä
#
XIš1Ë
ZËÌÚò€s©PQèé<=–ÃZþéNHa
%
(
Ëf1˃…HËÌÚòD<=HèéÔ¹
¾
(
31=:
,²!Œâ”
#
€<%©Â¾ŽH»“
G
#
]k<%©ÂHl{aD
#
z(œa97H,
Ö
(
iSSVH
31=:
Åsl{aD
*
11<1"
+
(
B
F31=:
Hª…®Sm
)äD5Ÿi”•Ì`
#
Ë@‡þ·ŸH
31=:
Ì`Sm)äD5Ÿ
#
31=:
HÌ`øSm8˜È
œ”54{0Á
(
SSVHþéNô…
#
”þP
>éN^EéNHª‚„n‡H¦¸
#
|0ÁZ
T@S
ã
!S
Hª…
#
i
T@S
Hª…”•Ì
`
#
Ë
!S
Hª…ã)äD5[`Ì`0Á
(
D
ã*Í{+¥É²
#
þP>éN^EéN67D
!S
Ï5ËD
T@S
HÏ5jk*H¸Ú`ÀÂ
ý
(
´*
12
+
DÙØTGHþP>éN^Eé
NãþÚsNcÁf)H/0z
#
Œ¥=k[›
Ë
T@S
H"¼—ƒDI³´
(
€<=G
!S
‚s
$
!S>
%
HªT5Gª
!S
Hªé‘I‡P
(

!S>
Hª…ß!Gø£T
#
Á@…ËÌ
ÚòŸ
!S>
Hª…ã)äD5`iÌ`Pø
SZ
>
Ä
(
+¥/0z
*
13<1>
+
#
þéNT
T@S
Û
¦½¾
!S>
#
Ÿ»@
!S>
|Èqèé<=a%þ
éN
(

#
!S>
HSª˜ñm¡T©ÂHz
7
(
!S>
ª…H–—
#
˜ñm–Ã<-D
!S
HŸ Õ P
(
} F < ¸ ¹ G È q  ‘
#
!S>
ã
PZ:1X141
€ËÌÚòJ@…ŸHªß!øS£
T
#
iËÌÚòH?ŸÿÏê¦n‡Z
!S

ª
(
/0z
*
17
+
#
!S>
ª…H0ÁŒ(œH—
s
#
D%Þ4{˜À*jk
#
Wi
+
ãäÿc
râx”z4—s
(
WX
#
BF!S>
HS
"0>
!!
"
!
#
!
$
!
!!
"
ªÅD4{H–—44[Õ,Ö
(
DméªP¾Ž#Hþ?
#
Æmªé½¾¾Ž
HŠf!
<
1s
<
<=P>
#
|ƒ˜½¾Š+Hš
?ŸÿÏêH4Æ©a%)*
(
ËÌÚòõ%P2
lþéNHÌA
#
ŀIž“VG("Šf!
<
1
s
<
<=P>Hz7X“
(
}BFH¸¹
#
T¾$*?H¸¹˜[›c
#
€<=G
T@S>
#
!S>
#
PZ:1X141
ã
31=:
Hª…ã)
äD5[`
#
ß!øS£T_º€@…ÔÕf)
(
PZ:1X141
€Á@…HËÌÚòèéŠ
#
ª…Ì
`øS
11
Ä
(
1ˀéªP¾ŽH*?a%þé
N7H…†Š
#
ËÌÚòþXZ<=a%þéN
(
ËþéNiþPU&kléªP¾Ž#xyH=k
cI
#
i4ƱFª«z7¾ŽH-kÇ
(
¶i¼
›,²þéNý¾Hfc›
#
5€þXãUµš
H4}Eœ»“Gz(œa97H,Ö
(
BFPZ:1X141
ª…HøS
#
1ËËÌÚòȜŗ
‹éªP¾Ž#*?HP¾Ž
(
T¾$*?¸¹[
¦Hi
#
‚P>?ŸÿÏêHjk
#
þP>éN^
EéNHª‚„Zn‡
#
I+>S
,²U&klP
>GªHKW
#
Dz…
)
/<
)
Uµ#$Wú97
H,Ö
(
ÇKWªHn‡
#
1ËDéP¾Ž*?
noP>Ïê3õùÌAH2lþéNÚò1n
‡
(
}
31=:
Hª…G
#
31=:
“ËÌÚò@
…HøSˏª–Ã
(
!Œâ”
31=:
T<%©
ÂHl{aD˜f
#
SSVH
31=:
ÓÅn‡<%
©ÂHl{aD
#
31=:
€<=Hz7»“GiI
J97Hâ-m
#
BF"
J@…Ÿ
H
31=:
ª…cSm)äD5
#
1ËËÌÚòD
<-H{…˜n‡,Ö
(
)s/0±I
*
1=
+
#
!S>
dVÁ¸
#
Ŕ
!S
þX¶i¼›Hª
#
iBF
(
¥mËÌÚò€¦4
}{|Hjk¦
#
;×44GÈq-»€˜ñm
klH4}{|DBÉÊËÌ
#
ª„(ìklH4
ƌ4@PœHÔ¹
(
A
!

D¾$ãéªP¾Ž#*?zAËÌÚò§
#
ËÌÚò€*?s©c44ZþéNÔÕ
#
_Ȝ
ÅjkþŒhHa%
(
þéNÔÕ-»Šf!
<
1
s
<
<=P>44Z?ŸÿÏê
#
_-»?ŸÿÏ
êÌ`n‡ZþP>éN^EéNHª
#
}Ëj
kZ*?P>G5l[fKWHª…
(
P>
G[fKWªH("
#
ȜT4{
)
!4V9W
»ÆPœù]H("˜defc
(
cd<=
*
1
+
!
ï¾´
#
ïÝZ
#
A¿Z
#
W
&
ËÌD+DRWXÝÿvç
)
€G¼ã­×Hjk
*
P
+
&
,ç+±
#
!011
#
!0
$
2
%!
10*
!
+
!
-
MA$
#
SFF
#
WCO
#
W
&
ÉÊËÌÚòŽ¼+¾aH/
0
*
P
+
&
G,9
#
!00=
#
"X
$
1!
%!
17="<17=3
*
"
+
!
›²Ë
#

#
­ÏÕ
#
W
&
ËÌÚòH/0XÙ
*
P
+
&
,ç.
+
#
!00X
#
!>
$
X
%!
13><1>!
*
2
+
!
$GK5;,(& G^
C
5;9V5D9$;5%5;H5ID9M5D9$;5%AFFAID:$F
S
J
6
<
D$A:DG$
C
A;:$;DJAGA
S
G$HEID9MADG5ID$FDJAAUA
*
P
+
&-T
S
AG9<
KA;D5%\9$%$
C6
5;H4AH9I9;A
#
1XX3
#
!0=
$
1
%!
=7*
3
+
!
lAj
#
­>Ã
&
þéN‚s
*
P
+
&
4ÈH¼+
#
!010
#
"0
$
2
%!
3X0<3X"
*
>
+
!
Yµy
#
ï‚f
#
­ÝZ
&
þéN‚sãþP4Æ/0XÙ
*
P
+
&
klý+XÙ
#
!003
#
!>
$
1!
%!
"3<"X
*
7
+
!
_µì
#
E–Ë
&
þéNH$KWŸ23€U&klþP4Æ
»“GH,ÖE‡
*
P
+
&
4l¼+T4ll}XÙ
#
!010
#
"7
$
>
%!
3X2<3XX
*
=
+
!
u[
#
Çtg
#
­Í´
&
þéN‚sã»G¼l›s–Ælé
ä‚s
1
̽*Ü+D\½¾H…Ô,ÖH;*
P
+
&
Guý¸ý+±
#
!011
#
X
$
!
%!
1>3<17!
*
X
+
!
r+É
#
4µ¬
#
[äÈ
#
W
&
*ܕÚòDP*?4Æ)*
Hjk
*
P
+
&
€4M}+:k
#
!00"
#
17
$
"
%!
1>2<1>>
*
10
+
R5µ
#
[U
&
Šf!P‰]¥@#^ÖüBò(½/<
*
P
+
&
ëõý+
!
_4.+aî
#
1X==
$
!
%!
2
*
11
+
)$D9IIJ9$+
#
,$::9+
#
\$G9;9(
#
,#"7&4$E:A$$I
6
DAKA9$D9IGA<
:EK
S
D9$;5;H
S
$%5GO$H
6
ATDGE:9$;9;M9DG$5GAH9FFAGA;D95%
6
9;F%E<
A;IAHO
6
R.[
#
A
S
9HAGK5%
C
G$UDJF5ID$G5;HKA9$:9:<5ID9M5D9;
C
:DA<
G$%
*
P
+
&[EK5;,A
S
G$HEID9$;
#
!002
#
1X
$
1!
%!
X1"*
1!
+
B95;
C
)+
#
[E$BP
#
_J$;
C
_.
#
,#"7&)
6
I%9I5HA;$:9;A"o
#
3oS
J$:
S
J5DAS
A;HA;D5ID9M5D9$; $F K9D$
C
A;<5ID9M5DAH
S
G$DA9;W9;5:A9;IEKE%E:IA%:9:A::A;D95%F$G
C
AGK9;5%MA:9I%A
OGA5WH$U;$F
S
$GI9;AIEKE%E:6
DA:
*
P
+
&-;H$IG9<
;$%$
C6
#
!003
#
12>
$
10
%!
22"7<2222
*
1"
+
*J$K5:,-
#
(GK:DG$;
C
@*
#
+9%IJG9:D,\&\$M9;AIEKE%E:
IA%<$$I
6
DA
C
5
S8
E;ID9$;5%I$KKE;9I5D9$;HEG9;
C
9;M9DG$K5DE<
G5D9$;9;GA:
S
$;:AD$K5;9
S
E%5D9$;$FIA%<:
S
AI9F9II
6
I%9I5HA;$<
:9;A"o
#
3oS
J$:$
S
J5DA%AMA%:
*
P
+
&\9$%$
C6
$F,A
S
G$HEI<
D9$;
#
!002
#
70
$
"
%!
32=<33>
*
12
+
´#
ïoÌ
&
ÙØþP>éN^EéN
$
+;,[
%
ãþP>
éNH^Ep:
*
P
+
&
GëÛý+±
#
1XX7
#
17
$
!
%!
177<17X
*
13
+
B9;H:A
6
( 4
#
)J5;;9;
C
)Q&)$K
S
5G9:$;$FDJA:D9KE%5D$G
6
AFFAID:$F$M9;A
#
S
$GI9;A5;HJEK5;F$%9I%A<:D9KE%5D9;
C
J$G<
K$;A5;H$F$M9;A5;HJEK5;%EDA9;9V9;
C
J$GK$;A$;DJA5IIE<
KE%5D9$;$FI
6
I%9I(4QO
6S
$GI9;A
C
G5;E%$:5IA%:
*
P
+
&P$EG;5%
$F-;H$IG9;$%$
C6
#
1X7X
#
=0
$
1
%!
X*
1>
+
NA::A%#
B9E]c
#
P95c)
#
,#"7&(ED$IG9;AG$%A$FA:DG$
C
A;:
9;DJA5E
C
KA;D5D9$;$F%EDA9;9V9;
C
J$GK$;AGAIA
S
D$GF$GK5D9$;
9;IE%DEGAHG5D
C
G5;E%$:5IA%:
*
P
+
&\9$%$
C6
$F,A
S
G$HEID9$;
#
1X=3
#
"!
$
3
%!
10"=<1030
*
17
+
­¤Æ
#
¹Y
#
žþ
#
W
&B[
"
)+
‚s/0XÙ
*
P
+
&
,çTÞ
F
#
!00=
$
2
%!
1*
1=
+
.D$II$)&(G$K5D5:AAT
S
GA::9$;9;DJA$M5G
6
!
[$GK$;5%5;H
K$%AIE%5GGA
C
E%5D9$;
*
P
+
&.DAG$9H:
#
!00=
#
7"
$
3
%!
27"<2=7
$
%&(
!
)*+
%
20>