Abstract:Squamostatin D(1), a new compound of non-adjacent bis-tetrhydrofuranyl annonaceous acetogenin,and a knowncompound 2,4-cis-and trans-bullatacinone(mixed,2)have been isolated from the seeds of Annona squamosa.The structure of squamostatin D was elucidated as (1) by its spectra analysis of IR,MS,1H NMR,C NMR and its acetylate spectra of MS,1H NMR.