摘 要 :雀梅藤(Sageretia gracilis Dunn et Spr. )又名对节巴刺、雀梅刺等,为鼠李科雀梅藤属植物,云南省红河州民间用于治疗疥疮、水肿、皮肤癌、乳房瘤及淋巴囊肿有一定作用,国内外迄今未见该属植物化学和药理方面的报道。为此,我们对该植物进行了化学研究和抗肿瘤药理实验。化学工作和抗肿瘤药理实验分别由昆明植物研究所和昆明军区总医院分工进行。雀梅藤根粉的乙醇提取物用醋酸乙酯和亚丁醇萃取后的水层经酸碱处理后,再用正丁醇萃取得到一结晶物质,于醋酸乙酯一甲醇中结晶为无色细棒状,熔点178—179度,分子式为C10H15ON·HCI,经质谱、核磁共振谱和红外光谱证明为麦胚碱(hordenine)(I)盐酸盐。正丁醇革取的中性部分经氧化铝柱层析分离,亦得到同一游离碱。
Abstract:Six constituents were isolated from the roots of Sageretia gracilis Dunn etSpr., a anti-tumor plant in Yunnan. On the basis of spectrometric analysis(IR. NMR. MS.) and preparation of derivatives, five of them were identifiedas hordenine (I), syringic acid (), vanillic acid (), 6-sitosterol and palmitic acid. The anti-tumor activity of hordenine (I) is explemented as 50.5% for S 180.