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Research progress on chemical constituents and their differences between Lonicerae Japonicae Flos and Lonicerae Flos

金银花与山银花化学成分及其差异的研究进展



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Researchprogressonchemicalconstituentsandtheirdiferencesbetween
LoniceraeJaponicaeFlosandLoniceraeFlos
YANGQianru1,2,ZHAOYuanyuan1,2,HAOJiangbo1,2,LIWeidong1,2
(1.SchoolofChineseMateriaMedica,BeijingUniversityofChineseMedicine,Beijing100102,China;
2.EngineeringResearchCenterofGoodAgriculturalPracticeforChineseCrudeDrugs,MinistryofEducation,Beijing100102,China)
[Abstract] ThedriedflowerbudsorinitialflowersofLoniceraeJaponicaeFlosandLoniceraeFlos,whichbelongtodiferentspecies
ofLoniceraorCaprifoliaceae,areusualytakentoclearawayheatandtoxicmaterialandtreattheexopathogenicwindheatTheyare
twodiferentherbs,andduetovariousreasons,therearefarmorecontroversiesThispaperreviewstheresearchonthechemicalcon
stituentsandtheirdiferencesbetweenLoniceraeJaponicaeFlosandLoniceraeFlosBothofthemcontainthesimilarchemicalconstitu
ents,suchasorganicacids,flavonoids,triterpenoidalsaponins,iridoids,volatileoilsandtraceelementsButtherearealsodifer
encesbetweenthemThemaindiferences:LoniceraeJaponicaeFloscontainsawealthofiridoidsandflavonoids,whileLoniceraeFlos
containsmorekindsoftriterpenoidalsaponins;thecontentofchlorogenicacidinLoniceraeFlosissignificantlyhigherthanthatof
LoniceraeJaponicaeFlos;thecontentofrutin,luteoloside,luteolin7OβDgalactosideandlonicerininLoniceraeJaponicaeFlosis
muchhigherthanthatofLoniceraeFlos;thecontentofFeandNiinLoniceraeJaponicaeFlosishigher,whilethecontentofMnis
higherinLoniceraeFlosFinaly,mainproblemsandsuggestionsonchemicalcompositionbetweenLoniceraeJaponicaeFlosand
LoniceraeFloswerealsodiscussed
[Keywords] LoniceraeJaponicaeFlos;LoniceraeFlos;chemicalconstituent;diference
doi:10.4268/cjcmm20160708
  
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Table1 ChlorogenicacidsinLoniceraeJaponicaeFlosand
LoniceraeFlos
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4
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1
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4,5
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4
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5
©ª «#¼>   [5,11]
3,4
€©ª «#¼‡  [15]
3,5
€©ª «#¼‡   [3]
3,5
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Table2 FlavonoidsinLoniceraeJaponicaseFlosandLonicerae
Flos
_V˜ ÎÏÐ ÒÏÐ ^”
y¢Û   [1,30]
y¢ê  +

béú1r

[1,31,37]
y¢Û
7OβD1“£ê   [21,30]
y¢Û
5OβD·¸£ê  [7]
y¢Û
7O
¥wA£ê  [22]
y¢Û
3′OαLRD£ê   [9,16]
Ÿ©ê  +2) [1,21,32]
3′
‡t1y¢Û  [7]
5,3′
€‡t1y¢Û  [7]
5
‚1
7,4′
€‡t1ÀÈ  [23]
5
‚1
7,3′,4′
L‡t1ÀÈ  [23]
5
‚1
7,3′,4′,5′
A‡t1ÀÈ  [23]
5
‚1
6,7,8,4′
A‡t1ÀÈ  [8]
3′,4′,5′,5,7´
‡t1ÀÈ  [26]
nxÛ  [7]
nxÛ
7OαLRD£ê   [9,16]
¼½Û  [30]
¼½Û
7OβD·¸£ê   [21,30]
¼½Û
7O
¥wA£ê   +1,2) [21,30]
ÎGÀÛ  [24]
ÎGÛ
7OβD·¸£ê   [24,33]
ÎGÛ
7O
¥wA£ê   +1,2) [21,30]
òAÛ  +1) [1,21,30]
ñ>   +1,2) [1,21,30,36]
òAÛ
3OβD·¸£ê   [1,33]
òAÛ
7OβD·¸£ê  [25]
ÎÑûê  [1]
Òv¢  [35]
Òv¢
3OβD·¸£ê   [24,31]
Òv¢
3O
¾?£ê  [1]
ÕRDÛ
3OβD·¸£ê  [24,34]
Àò¿Âê
B  [10]
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(1→2)αL¯ °K­£1ÇÄæ¼28OβD¯ °
·¸£1
(1→6)βD¯ °·¸£ê[23]、ÇÄæ¼28OαL
¯°RD£1
(1→2)[βD¯ °y£1(1→6)]βD¯ °
·¸£ê
[24]、
Ÿ©Tê
E[39]。
32 
ÒÏÐ
 
쏧[Ÿ©ÒÏÐ$w^Âéê~QLè
é걫¬*ú

ÒÏÐ$L/B§[Ÿ©éê‡
[31]、

§[Ÿ©éêm
[31]、
 ,éêm
[31]、
§[Ÿ©ºéê
‡
[31]、
§[Ÿ©ºéêm
[31]、αw^Âéê[31]、w^Âé
ê~
28OβD¯ °·¸£1(1→6)βD¯ °·¸£
ê
[31]、3OαL¯ °K­£1w^Âéê~28OβD¯
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(1→6)βD¯ °·¸£ê[31]、3OβD¯ °
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£1

w^Âéê~
28OβD¯ °·¸£ê[33]。
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ú

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[40]、
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28OβD¯ °·¸£1
(1→6)OβD¯ °·¸£[34]。ïð,¿§[Ÿ©ÒÏ
Ð$Ám±DÁB¡r¼±Lèéê

›Ÿ©¡r¼éê
lonimacranthoideⅠ~Ⅴ[4143]。
Åü“ì
220
lÒÏÐ#¤Önëßáâ

Ͼ]
*
3[44]。
¦*

$Ma½d

ÒÏÐ$éêëßvwÝ


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1325%,
 ,éêms
1462%,
åÅ
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m

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©

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3 
ÒÏÐ$§[Ÿ©éêm¬ ,éêm±
ëß
[44]
Table3 ThecontentofmacranthoidinBanddipsacosideBin
FlosLonicerae[44] %
1r
#9
=
_
–—
Q:
y

y
%u
y
ÂÈ
ÛÔ
 XŸ©
70
§[Ÿ©éêm
031 885 357 195
 ,éêm
019 835 282 148
Æ9Ÿ©
25
§[Ÿ©éêm
026 715 532 254
 ,éêm
025 196 058 036
ˬ[٩
55
§[Ÿ©éêm b‚d b‚d
- -
 ,éêm
090 1462 711 336
§[Ÿ©
70
§[Ÿ©éêm
425 1325 816 170
 ,éêm
033 215 096 044
ÒÏÐu°
220
§[Ÿ©éêm
026 1325 578 288
 ,éêm
019 1462 305 313
33 
ñò
 
LèéêÄ_V˜ÉÒÏÐJ`ŸÎÏбL
/–—

]*
4。
Gao
è
[45]
ì

Ÿ©ÇŽ˜
———
ÎÏÐ

§[Ÿ©

 
XŸ©

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ˬ[٩

[ДŸ©

Z§[Ÿ©$
82
_V˜±_ÄQ

Bf¼Ä

MBCèÄ

ÀÈÄ

éêÄ
aÊÓâ_V˜

ÖnD—Ä

œæ*ú¥¦Ÿ©ÇŽ˜±_
–—÷–¥¦

ÎÏÐ$¥ëLèéêÄ_V˜

§ÒÏÐ
¬Ó⟩ǎ˜${Äò•

Ó$À¨[Ÿ©ÒÏÐ$
LèéêÄ_V˜ÄúhòÓâ1rÒÏЕ

Chai
è
[46]
ñòDÎÏÐÑÒÏÐ

§[Ÿ©

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©

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$§[Ÿ©éê‡

§[Ÿ©éêm

 
,éêm

w^Âéê~
28OβD¯ °·¸£1(6→1)
OβD¯ °·¸£ê、§[Ÿ©ºéê‡、§[Ÿ©
ºéêm

w^Âéê~
3OαL¯ °K­£1(2→1)
OαL¯ °RD£êè7L/Lèéê±ëß,œæ*ú
ÎÏÐ$OëB ,éêm

åëßò

1rÒÏÐu
t

Æ9Ÿ©ÒÏЬ§[Ÿ©ÒÏÐ$uëB’

é
  
*
4 
ÎÏÐÑÒÏÐ$±LèéêÄ_V˜
Table4 TriterpenoidalsaponinsinLoniceraeJaponicaeFlos
andLoniceraeFlos
_V˜ ÎÏÐ ÒÏÐ ^”
§[Ÿ©éê‡
+  [1,31,46]
§[Ÿ©éêm
+ +1) [1,31]
 ,éêm   [1,31]
§[Ÿ©ºéê‡  [31]
§[Ÿ©ºéêm  [31]
αw^Âéê   [31,38]
 3OαL¯ °RD£1(1→2)αL¯ °K
­£1

w^Âéê~
28OβD¯ °y£
1
(1→6)βD¯°·¸£ê
 [38]
 3OαL¯ °RD£1(1→2)αL¯ °K
­£1

w^Âéê~
28OαL¯ °RD
£1
(1→2)[βD¯ °y£1(1→6)]βD
¯°·¸£ê
 [38]
 
w^Âéê~
3OαL¯ °K­£1
(2→1)OαL¯°RD£ê
+  [1,46]
w^Âéê~
3OαL¯°K­£ê  [24]
Ÿ©Tê
A~E  [39]
 
w^Âéê~
28OβD¯ °·¸£1
(1→6)βD¯°·¸£ê
+2) [31,46]
 3OαL¯ °K­£1w^Âéê~
28OβD¯ °·¸£1(1→6)βD¯ °·
¸£ê
 [31]
 3OβD¯°·¸£1(1→3)αL¯ °R
D£1
(1→2)αL¯ °K­£1w^Â
éê~
28OβD¯ °·¸£ê
 [33]
 3OαL¯ °RD£1(1→2)αL¯ °K
­£1

ÇÄæ¼
28OβD¯ °·¸£1
(1→6)βD¯°·¸£ê
  [23,40]
 
ÇÄæ¼
28OαL¯°RD£1(1→2)
[βD¯°y£1(1→6)]βD·¸£ê
 [24]
 
ÇÄæ¼éê~
28OβD¯ °·¸£1
(1→6)OβD¯°·¸£
 [34]
lonimacranthoideⅠ~Ⅴ  [4143]
  
å
:1)
 ¨[Ÿ©
;2)
 XŸ©

ê

Ó$§[Ÿ©éêmëßQÝ

 XŸ©ÒÏÐ$L
/éꖗɠ,éêm

åb‚ádw^Âéê~
28
OβD¯ °·¸£1(6→1)OβD¯ °·¸£ê。
4 
MBCèÄ
MBCèÄ_V˜ÉÎÏЬÒÏбL/¢˜µ–
—

åwaê±_ó¿

41 
ÎÏÐ
 
ÎÏÐ$ê
[1]、7
*R‘Û
[1]、8
*R‘Û
[1]、
Çyȼ
[1]、8
*Çy
ȼ
[1]。
ÝMMBCèÄ_V˜Bɓxê
[1]、secologa
nin[47]、secologanoside[48]、
ÝMR‘¼
[1]、secoxyloganin[48]、
€
‡t1

ÝMR‘Û
[22]、
R‘ïê1b(8
[1]、7
*R
‘ïê1b(8
[1]、dimethylsecologanoside[1]、secologano
side7methylester[1]。
ïð

ÎÏÐ$ÁëB@¸!!ü‘
€Á

œ÷Ê]±€K°MBCèê
centauroside[49]。

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Vol41,No.7 April,2016
è
[50]
Hº¿ÎÏÐ$m±

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m 1R‘ïê1b(8
、6′O
m 1ÝMt
_R‘Û

R‘Û
7
È
、7αÌzê、7βÌzê¬Îîê。
Rü–è
[47]
áâDÎÏÐ$±É“xê

R‘ê

R
‘ïê1b(8
、secoxyloganin4
MBCèê±ëß

Ó
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038% ~046%,007% ~014%,
030%~038%,033%~041%,
C9ãÎÏЕ
021% ~
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tHè
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è
[51]
¦§[Ÿ©j©Ð ±¢#˜$—ž<äD
seoxy
loganin
¬
secologanoside。
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5 
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Table5 IridoidsinLoniceraeJaponicaeFlosandLoniceraeFlos
_V˜ ÎÏÐ ÒÏÐ ^”
R‘ê  +1,2) [1,35,52]
7
*R‘Û  +1,2) [1,52]
8
*R‘Û  [1]
Çyȼ  [1]
8
*Çyȼ  [1]
ɓxê +1,2) [1,52]
secologanin  [47]
secologanoside   [48,51]
ÝMR‘¼  [1]
secoxyloganin   [48,5152]
€‡t1

ÝMR‘Û  [22]
R‘ïê1b(8  [1]
7
*R‘ïê1b(8  +1,2) [1,52]
dimethylsecologanoside  [1]
secologanoside7methylester  [1]
centauroside  [49]
ÝMR‘ïê
A  [50]
6′O
m 1R‘ïê1b(8  [4]
6′O
m 1ÝMt_R‘Û  [4]
R‘Û
7
È  [4]
7αÌzê  [4]
7βÌzê  [4]
Îîê  [4]
  
å
:1)
 XŸ©
;2)
Æ9Ÿ©

Li
è
[52]
ñòDÎÏÐÑ XŸ©ÒÏÐ

Æ9Ÿ©Ò
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7
*R‘Û

ɓxê

R‘ê
、7
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(8
、secoxyloganin
è

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œ
æ*úÎÏÐ$ëB’

_V˜

åɓxê
、7
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secoxyloganin
ëßòÝ

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secoxyloganin
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5 
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[53],
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Ä

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BÐ蕍_–—–

øÑ
[54]
ìÎÏЈm÷$_–—±<âœæ*ú

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•

}€ìëßòt

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、¨
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BÄ_V˜

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{Јm÷_–—¿ò…ÔÕ

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L/ʱҨ

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?€öÎÏè$thë_V˜–

jЈm÷L/Ê
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ðͼ‡èaÊÏÐÄ$Ýhë_V˜
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[55]。
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ÎÏЈm÷$L/–—É[%¼
、ζ·á÷B、ðͼ‡
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¿[âÔÕ

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Ճ€‡¼€>

?n¢è

åëßuòÝ
[57]。
52 
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쏧[Ÿ©ÒÏÐ$ˆm÷±«¬*ú

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、6,10,14
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[58]。
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ö
1228%[60];
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ö
1017%[61]。
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779,3199,310,146mg·kg-1。
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