作 者 :胡元春,谢雁鸣,杨薇,王永炎,王连心,唐浩,庄严
期 刊 :中国中药杂志 2014年 39卷 18期 页码:3509.
关键词:参麦注射液 ;肿瘤患者 ;医院信息系统 ;联合用药 ;真实世界 ;用药特征 ;
Keywords:Shenmai injection , tumor patients , hospital information system , combination drugs , real world , characteristics of drugs in clinical ,
摘 要 :参麦注射液是临床常用补益类中药注射剂,为了解参麦注射液治疗肿瘤患者的年龄、性别、用药剂量、疗程以及联合用药等临床特征,该研究选取全国20家三级甲等医院信息系统(hospital information system,HIS)中使用参麦注射液治疗肿瘤的患者信息,通过分析发现使用参麦注射液的患者多为45岁以上的中老年人,共3 338人,占79.36%;男女比例为1.73:1;患者住院天数多集中于15~28 d,共2 080例,占总人数29.15%;使用参麦注射液的肿瘤患者常合并有高血压病和冠心病;患者中医证候多为气阴两虚证,其次为痰瘀互结证;参麦注射液治疗肿瘤患者单次使用剂量分布为81~100 mL最多,共有8 491例患者,占总人数48.70%;用药疗程平均为5.44 d,疗程分布最多的为1~2 d,共12 186例,占总人数68.89%;采用关联规则方法分析参麦注射液治疗肿瘤患者的常见联合用药为地塞米松(支持度为44.63%),托烷司琼(支持度为31.22%),甲氧氯普胺(支持度为20.53%),泮托拉唑(支持度为20.03%)。
Abstract:The study was to research the clinical characteristics of Shenmai injection treating tumor based on hospital information system, including the characteristics of the age, the sex, the dosage, the course of the treatment and the combination drugs. The data of tumor patients injected with Shenmai injection was analyzed. The information was collected from the hospital information system(HIS) in twenty hospitals of grade Ⅲ-A. The method of frequencies and association rules was used in this reaearch. The patients over 45 years old were up to 3 338,about 79.36% of the whole. The ratio of male and female was 1.73:1.The hospitalization day between 15 and 28 was most. The complications of the hypertension and coronary heart disease happened most. The support was 5.939% and 5.099% respectively.Fifty-five patients had the traditional Chinese medicine(TCM) syndrome of Qi-Yin deficiency, about 14.78% of the whole. There were 8 491 patients treated with the single dose of 81 to 100 mL, about 48.70% of the whole. The main combination drugs were dexamethasone, tropisetron and maxolon. The confidence was 44.63%,31.22% and 20.53% respectively. The information from HIS showed that tumor patients used Shenmai injection were most quinquagenarian with smooth condition. The dose of the Shenmai injection sometimes was higher than that of the drug use instructions in clinical. Shenmai injection was most often combined with glucocorticoid,antemetic and nutritional support medicine when treating tumor in clinical.
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