免费文献传递   相关文献

Study on anti-oxidative effect of extracts from Cichorium endivia on HepG2 cells and its mechanism

苦菊提取物对HepG2细胞的抗氧化作用及其机制研究



全 文 :ŽAB€°
FBHI*
óôŠŒŠ‹‡ÓŸ ”•
Iõ&
!*
!
öÜ¥
*!)
!
֥w
&
!
øùm
&
!
jÅH

!
lúŒ
*
!
d
t4±ªO‰ t4“ɉS&ú,-©
!
t4 t¨
)$$(%
*d
©·±‰ª‰ ~ŽÅƱ‰ ɉS&,-g–©
!

$$$$%
)d
©·±‰ª‰ ~ŽÅƱ‰ ·Ü.Õ/©
!
01.Õ/±
!
©·Ë¥·2±‰g–© .Õ3/·ÜŸ ¡¢£
!

$$$)%%
&d
~ŽÅÆ44±‰²³56…†sµ‡ˆ
!

$$%#%
d
©·±‰ª‰ ~ŽÅƱ‰ ‰šg–— ©7‰š«ðñ¯¸‘qµœžŸ ¡¢£
!

$$$$#

kl
#!

&
÷zŽAB€
!°
F
*
L
*
b
FBHI*
óôŠŒ–„cdžŠ‹
$
eí3ŽAB€
FBHI*
ó
ô$ŠŒŠ‹Ÿ 
%
ŠŽ
#
BC
9TT

Y<`F5Y3
Þ¸©ý
$
>F
F
*
L
*
Íê
FBHI*
óôÕÖÝô8
>L8


Š
Œ›–w6
!3>V
a>û٘©†s
FBHI*
óô8>F
3>V5GU-JQBR?KB
ÕÖ

eBCÞ¸sŽ
>T5C<>
Fs
FBHI*
óô
8rD
3>V
mn¬’ûف
/>;3
Œ®P¶
%

#F
*
L
*
Íê
FBHI*
óôˆ
$
óômÕ_µÞ
$
ô8
>L8
P¶$·
$
é2¡
/0‡ñ
GèøÅ67$”Çð
%
/0‡ñ
Í꘩
3>V
a>ûف
FBHI*
óô
$
èµóô8
3>V
ÕÖ
1‡ñ‚Ög$
%
Ÿ¯
$èµ
FBHI*
óô$r
3>V
mnªäûÙ
IÝ
F9L^ 5

/>;3
Œ®P¶$
ª
$
e1‡ñ‚Ö
%
‘
#BCÞß
>L8

$
Ô 
F
*
L
*
¨©
FBHI*
óôcd
$
é
°
FBHI*
óôŠŒž
Š‹Ÿ èDøӄÕ
FBHI*
óô8
;RQ*53>V
BP¬’ŠŒbc“¤./¬’
%

mno
#!
Ž

Õ֊

ŠŒ›–w6

–ž

pq)(
#!*$)55**

r s t P
# !
% J
.
¥ i T , ë  
/
& ( ¥ i 7 M
!*$)_^ $4)$*)$*
%JK<&û¦MB
!()$*%#
>vJK
<&û¦MB
!*$)X$(
>vC&iU^Î-û¦MB
!*$]K$$)

uvwx
#!
!
!ª¶
$
”•Æ
$
€þß,ê¦ê”•
$TBD#
!$$()#4)&4$ V5/?JD# +?1A?JHJ1A2J//d?-d-1
!!

0
$%L€.
1
û
$
ŽÊ§L€Ÿ%
€D
)
À
#
ŽÊ
6(7:.*(+, (&4?O+2&
‹vŽÊ
6d)5%&9+5.2+,W.JKK
ݍŽ
6d0&9(>(% Gd$
Ó$C
*
À1n¡Ÿ%,
$
ӀD▝Þ
&
aHSP
&

ySk†‘
%
ôR,ꔕ?cô
$
g€D
Ðݞ–Š‹
$
e¿À±V·¯
&
xyz‡±y
ñ·¯ÿR®Öðz3L€D&.
(5))
%
¬£iµ
$
Ž{<øgŒ»­¬>
$
rÃD¬’,êŠ
‹aÄ
%
¯»ŽŸ%iL¼ÀL¯S
$
,‹øc¤ò’³
%
Žå@¯SŽÊ
$
یÊ
$
@%À¯S

$
LK@ šÒªabPq
$
Ó#T»­ø
ӏŠŒÕÖD’
(&)
%
D!aÄ
$
õö¯SŽ
8ÊŽ§L€Pú:€Dâ^KÓû
&
D‘‰b
ŸaŒŠŒ–„cdD.
(5#)
%
Ÿ¯
$
sžd
CvrŠcô
$
ŽAB€
!€Dâ^a
¯
YCCF*
Ý
L
i
*
*
ÿKÓûŠ‹
$
óôÝ-€P
¶$€Dž–óôcd†‘
$
ӊ‹Ÿ èD
øŠŒŠ‹D’
(%5()
%
s”•º
FBHI*
óôP
¶$—%Øí3
ŠŒŸ 
%
!
ÿ
`!
AB€ 
!
ŽIK23TcHËÏ;c
$U
$
œ$%C&4,€”•5Ó¦\Éxs
óŽ&ŽÊ§L€¯SŽÊ
6d0&9(>(%%
bCD
•µ
#
Žˆ1mÌ
d( [A
œ
4k
&%¿ßAB
)
Ù
!($ Gp* O$%$ Gp O$#( Gp O$
C…¹e…
:
$
šH‡Ž5òA€ÿ«ü
%$k
&%ú:$
%
ÿ
«:ï~œ‡=ˆ•B
&
Ù
!*$d$d$d G$
5
ò´&%œšH‡ŽSê%4
$
2Pÿ«;
*d) G$
eœ&ñ&u•B
)
Ù
!d$d*$d* G$
•B
ˆ5òP;
*d* G$
Ci8ʐ$V
$
Ó$
#$k
&
%1­‡Žˆ<ˆò´¥;
&$ A
ÀýŒëÒ÷
$
ó
ó
sRI¡°
—d­;ÝÇÈxs
$
×Ø
cô¢

SŒ¹€
$
g­y@
*5
Ì%
5!m
(
5$)5
OzY{e
($&5-)5F5
ÍÎ
$
I@’
$
I@’
5)5S
!
#5
*#%**
t
)4
¥t
&
v
*$&
o
%
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
\.Dd)4$:KKUB!&
XUD6$ *$&
()xW
$
‹WÝj&%()xW
$
Ó$
*5
Ì%
5!m
(
5$)5
OzY{e
($&5-)5F5
ÍÎóTcôŒ¹
€
$
I@’‡Ó†O€èD@
€ŠŒÕÖ
»­
(()
%
†I@’‡Ó†O€óB~€
$AB

%k%
uًQŒBêÇrq
$
RIC‹/r·
âST:!+»5q‡ñ
$$d**
!
/
…¨C…ˆ
$
‹
üa¯RI
%
(`!
ô*
!9TT
Ý
Y<`Y3
ÅIK
8JA/?53DSRJ-O
FG

CŠŒZ
!F
*
L
*
$)$k
IK%,(ތô
*DEFG
Èz¦
3>V
ûÙa>Áô*~
Ó>%
83WJ.K-JB1-BK
FGAÎ
GU-JQBR?KB
a>ûÙ
>F“¤Ó>%
CR./BA?
FGAÎ
T>:Z.D
IK
:15
eJPR.AB1
FG

rD
9UGš˜ÑùÝÏRWñ̀
“¤Ý
8NW>IRBB1
ô*~Ó
3HHDJBS WJ.K6KPB/
F
GAÎ
%
&`!
ïy
!E\5*#$
Ö¯­¸¸ñ
!
qs-ù

8HB-PR?9?74$
ù~ï
!
>%
9.DB-UD?RYBeJ-BK
8HB-PR?9?7IB/J1J^ 8
Þ¸ù~ï
!
>%
9.DB-UD?R
YBeJ-BK:^5%$
Þ¸éÍÅÆW
!
qs
LD6/HUK
3W:C>:89%4$$
Þ¸sŽ
C<>
ï
!
>%
3HHDJBS WJ5
.K6KPB/K%
(!
34
( `!FBHI*
óôST
!FBHI*
óôÓ$%C
&4,€”•532\ÉAÎ
%
ë‹r
$k
:
†·â
! <`8

Y9V9
STûST
FBHI*
óô
$
u
* S
™:

Ù
$# S
YR

Ù
%
( (`!
­Íê
!
°Ä2¡ê·â
Y9V9
ST
:

!2¡r
F
*
L
*
!
f‡ñó
& //.D*G
i


ê·âSTû

¿ÀÍêø!%re2¡
/0‡ñŽAB€
%
( &`! 9TT
4>FóôÕÖ
!
B°?O˜v
FBHI*
óô
$
‹
$d*k
,ùSŒ:SŒóôˆ
$
‹r
$k <`8

Y9V9
STûºóô«:ªS
p$

S
=/G$
eÀü
4#
8<8
$
u8
$$
!
G%
u

#
S¯8
$
Íü
)% x$k*
ST\$ST
*&
O%
͆$
( (`
M—d­Íê
$
eï~ST
) O$
2
¡
9TT!
f‡ñó
A*G
i
$
ï~ST
& O
ˆ
$
Ð$â

*$$
!
GY98L$
Ñ`Åñ
$
ù~ïü0˜
& 1/
ÍFs
@%
óômÕ_
o( i!@
K
=@
-
) p$$k%
Ó$
$@
K
óAFrq
$@
-
ó¿}°Ä
%
( `!
óô8
>L8
P¶>F
!
B°?O˜v
FBHI*
óô
$
‹
$d*k
,ùSŒ:SŒóôˆ
$
‹r
$k <`8

Y9V9
STûºóô«:ªS
p$
#
S
=/G$
eÀü
#
8<8
$
u8
* /G%
Íü
)%
x$k *
ST\$ST
*& O%
Í
( (`
M—d­
Íê
$
Íü
)% x$k*
ST\$«V
O$
>F
C
)$ /J1

Y<`F5Y3!
f‡ñó
$
!
/.D*
G
i
%
>FQ
$
óô™:ó
* /G

CW8$
„c0
˜ó
&( 1/$
c.0˜ó
)$ 1/
Þ¸ù~ï$
>FÞ¸$ñ¤
$
e»ˆüÞ¸éÍÅÆW$øÄ
%
( $`!3>V
a>ûÙFs
!Èz¦
3>V
a>
Á
!VRBH.RPBR
@%Àš
;RQ
Ý
;RQ*
ªä
3>V
¥¯mne0DxŒ®Þ¸;ù
!GU5
-JQBR?KB
ûÙ
%
s”•–‹ÏûÙa>Áô*~
 Š
FBHI*
óô!
$
‹
d$ /A*G
i
01;
!HUR./6-J1
—d3Ã
$
vw†s˜©
FBHI*
ó
ô“
%
º†s˜©
FBHI*
óôeÀü
4#
8<
8
$
O˜S.ñó
4$k

%
µ‹rD/0‡ñ
ST:Íêóô
# O%
BC>F
GU-JQBR?KB
ÕÖ
$
yz,€Íꈰ
3>V
„Õøù
% GU5
-JQBR?KB
ÕÖµ‹
GU-JQBR?KB
a>ûÙ>F“¤—d
>F
$
Ø_ºÄçøh
$
0Q–‹
9TT
£ý4>F
óôÕ.—d*^
%
( X`!/>;3
ABÝsŽ
>B?D5PJ/BC<>
­®
!
/0
‡ñ
Íê
FBHI*
óô
# O
ˆ
$
–‹
T>:Z.D
—
d
FBHI*
óôk
/>;3
AB
$
µ‹
*#$$*($ 1/
0˜Ö¯­¸¸ñ—d
>;3
OŽœ£
$

ˆ
/>;3
úßü
YVC<
P$
$
Íü
i($ x
m
‹
%
RQsŽ
C<>
õŠ34ºÄ!
(4)$
ۯ
_•µ
#
óôk
/>;3
–‹rD
9UGš˜ÑùÝ
ÏRWñ̀“¤—dš˜Ñ
$
µ‹
8NW>IRBB1
ô
*~Þ¸sŽ
C<>
ï$—dsŽ­®
%
sRI$–‹Í€õö
IF9L^ 5
Ý !
5?-PJ1$
̀mnhŒ
%
µ‹
CRJ/BR
V7HRBKK)
Ê6
!3HHDJBS WJ.K6KPB/
FÍ€
$
̀
¹»Ó
9MI5W:LTVFG
!FJAO C.J1P$;<
ö»
%
/0i`ûٌ®¬°À*–‹ÂO?
!6
P

ŒF
%
sRI$>F¬’Í€
6
P
Å:ü
)$%
u
Srq
6
P
‹ !
5?-PJ1
—d*^
$/>;3
Œ®Ž‹
6
P
ø°Ä
6
P
£¤5ò?ŒF
%
( %`!
¤34
!
RI?Ƌ %
Ih2
ŒF
$
eë‹
8C88 %d$
¤Ê6õ—d¤­®
$
`£¤ë
‹3Ù;3À­®
!L1B5M?63;L\3$
ÃÌ
G8Y
>I4
$$g$d$
ó¤$DÅ¿ÖÀ*
% !!
*%%**
t
)4
¥t
&
v
*$&
o
%
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
\.Dd)4$:KKUB!&
XUD6$ *$&
Œ!
RQsŽ
C<>
Í€mn
T?]DB!CRJ/BRKBaUB1-BKJ1 >B?D5PJ/BaU?1PJP?PJeBC<>
ûÙ
IB1W?1[
< Ês
=]H
mn
!m5)m
!
5?-PJ1 $^$) $(( f $#) #`IT<<3<#I<3TTTII#3II#TITTT3I<333TI<3IT<333TF9L^ 5 ;9r$$*)) *# f *4& #`I<#II<&!
Çð
& `!
°
FBHI*
óôÕց¾¿
!& //.D*G
i

F
*
L
*
Íê
FBHI*
óô
) O
ˆ
$
DÍé
FBHI*
óôc
d
$
ó!óômÕ_ø°Ä¬£
$
µÞS
(d((k!$g$d$ % èD‘b€
F
*
L
*
°
FBHI*
óôcd
$
ø!¬£
$*$$$$$ /A*
G
i

ZDA±óômÕ_
!$g$d$
2
$g$d$$
e1‡ñ‚$%
$

*%
Œ
*!°šc
FBHI*
óô¾¿
!
%
Ih2
T?]DB*!VQB-P.Q%
Ih2
y

=/A*G
i
óômÕ_
=k!&o#
Þ¸$ñ
!&o)
°Ä
i $$d$$ hd% #d(# h$d4
!
i
(d(( hd#*
*
)d$& hd$)

*
#*d%% h*d$
)
(d)4 h$d*
)
$
##d*4 hd%(
&
%d4 h$d$
)
$$
%$d* hd&#
&
%d* h$d)%
)
!!
³
#
ø°Ä£¤

$g$d$$
*
$g$d$
ø!£¤
)
$g$d$$
&
$g$d$%
& (`!
°ô8
>L8
¾¿
!
ø°Ä¬£
$& //.D
*G
i

F
*
L
*
Íê
FBHI*
óô
O
ˆ
$
óô8Þ
¸$ñÅ¿g2
!$g$d$$
çø
F
*
L
*
DÍé
FBHI*
óô8
>L8
P¶·±
% èÅ¿Þ
ߚc
FBHI*
óô8Þ¸$ñ
!
ø!¬£
$g$d$$
e1‡ñ‚$%
$
øÞ¸ÅÆWµ
5hÇð%b
%
ӟAF
èBCÞß
>L8
P
¶žšc
FBHI*
óô
$

*
Ýg
%
& &`!
°
FBHI*
óô8
3>V
a>ûف¾¿
!
‹
/0‡ñ
Í꘩
3>V
a>ûف
FBHI*
óô
# O$
yz*Ž‘–
%
Çðcô»
‡ñ
g2
$3>V5GU-JQBR?KB
ÕÖæg$
$
LJñg2S
($ /A*G
i
Q
$
Ó
3>V
a>ûÙÕÖø°Ä¬£
DÅ¿ÖÀ*
!$g$d$$
Ó$
#$ /A*G
i
Í
é
3>V
a>ûÙÕÖé$
$
ø@Ö°Äqá¸û
!!
3d
°Ä
Wd

i

Íê
%
g
!Y<`F5Y3
Þ¸©ýˆ
FBHI*
óô8
>L8
áŒ
! p$$
J`Ad!<./H?RJK.1 .Q>L8 J1 FBHI* -BDK+JPO Y<`F5Y3QDU.5
RBK-B1-BKP?J1J1A! p$$
°jY’
!45WFb
‚
$
é
)*$ /A*G
i

Í
é
3>V
a>ûÙÕÖø
#$ /A*G
i
¬£1g
˜šä$%
$
hg
*%
& `!
°ô8
3>V
¬’ûف
/>;3
P¶¾¿
!
°ºÄ€ !
5?-PJ1

/>;3
Œ®P¶ø°Ä
êÅ¿ÖÀ*
$
éDµ
FBHI*
óô$r
3>V
m
nªäûÙ
IÝ
F9L^ 5

/>;3
Œ®P¶$ª
$
e1‡ñ‚Ö
%
ӟ×؋ø
èBCg$
3>V
ÕÖ
$

IÝ
F9L^ 5
ûف
/>;3

$
hg
)%
!

F
*
L
*
@%À$ŠŒ*
$
è6eb³¡óô8
øóônÀ»­¬îŠ‹
$
eær΁–óô8
˜áó
*LF% *LF
ÿKÓûèb
Y;3
tk„
$
e
øóô¥€»­é›–
$
èåĨ©V$‘
/iÝVüñ
!CE`3$
Íc¨VOCŠŒ¾þ›
–
($)
%
s”•$
$F
*
L
*
DÍé
FBHI*
óô8
>L8
P¶$·
$
»»ô8ŠŒ–„P¶·±
$
þ
é°
FBHI*
óô»»cd
%
é
%s‡ñµ
èÔ 
FBHI*
óô8
>L8
P¶$·
$
D‘ž
FBHI*
óôŠŒ–„cd
%
ǹsžd­C
rŠ
$óôÝ-€P¶$Z€D–ž
*(%**
t
)4
¥t
&
v
*$&
o
%
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
\.Dd)4$:KKUB!&
XUD6$ *$&
!!
ø°Ä£¤

$g$d$$
*
$g$d$%
g
*!°
FBHI*
óô$
3>V5GU-JQBR?KB
Õց¾¿
!&o&
J`Ad*!VQB-P.QV5GU-JQBR?KB?-PJeJP6J1 FBHI*
-BDK!&o&
3d
!
5?-PJ1WdIø°Ä£¤

$g$d$%
g
)!°
FBHI*
óô$
3>V
¬’
/>;3
Œ®¾¿
!&o)
J`Ad)!VQB-P.Q;3B7HRBKKJ.1 RBD?PBS P.3>VJ1
FBHI* -BDK!&o)
Š‹
$
ӊ‹Ÿ èDøa8ŠŒÕÖ»­
!
•
I8F


g2D’
(()
%
ٟ
$
s”•º—%
ØI‹
@_°–óô8ŠŒbcŸ €D
ª’Š‹
%
;RQ*53>V
l ¥€ö÷i%
%
†DցŠŒ›–w6
!?15
PJ.7JS?PJeBRBKH.1KBBDB/B1P$ 3>V
ªärûÙmn
B+rD
m5ITI3<111I<5)m
܎
$1
èŒFXÊR

()
%
RÙÁ
5V*5
¬’ÙÁ
*!1U-DB?RQ?-P.R5BR65
POR.JS *5RBD?PBS Q?-P.RK$;RQ*$
BCø:
9?Q
Ý
XU1
|}a»*YÈa
$
±ø
3>V
ǹˆÎ-ŠŒŠ
‹¬’ûف˜Ñ
%
D”•aÄ
$3>V
DÒ©%¬
ߦù
!
õö¤ý—
5A
˜«ù
$I8T&;3Y!CF#
jҊŒ?Éù
(;3Y!CF#aUJ1J1B.7JS.RBSU-P?KB
$;bL)&
“η?;2Šù
( OB/B.76AB1?KB
!SB-6-DJ1A $F9L^ 5)
ݏŠŒù“•CŠŒZ
ù
!-?P?D?KB$<3T$
ڊ?|}
!KUDQJRBS.7J1$
8>^ $
$
5
¤þ¶ýþñ¹»ù
!
$
5I<8
}Œ“û
!ADUP?/?PB5-6KPBJ1BDJA?KB$-?P?D6PJ-KU]U/JP$IÝ´T“û
!ADUP?/?PB5-6KPBJ1BDJA?KB$/.SJQJBRKU]5
U1JP$I˜Ñ
$
»òçùóô8rŽ¬
°g‘
$
óô8ŠŒbcD.g$
$
þéc<
žóôݐŒŠ‹
(*)
%
$
5I<8
Ûå¤þe
5
¶ýþñžeù
!IÇ
3TC
mQ
$ID}Œ¤þeø¶ýþñÇ
¹a» $
5
¤þ¶ýþñ
$
»ˆ¤ý—¹»ù
!I8
$
5
¤þ¶ýþñ$2¡—þñ
$
éfa»
€DŠŒÕց?ɤý—
!I8F% I
*
S“ûÈ»
$
%Sà¾2î´T“û
!IÝ!¯%S¥¾2î}Œ“û
!IXîûفÎ-Á$ZrD
3>V
mn
())
%
Ÿ
¯
$
Q
CA
Î-Á$cô
*

;RQ*
ǹ&
Ês
%
·?;ŠŒù
5!OB/B.76AB1?KB5$F9L^ 5
@
­ß}ŠŒ€·?;»ó%ŠŒû
&
Þ¨;ÝÁ;
Î×MŽEõù
% ;RQ*
D6eª’
F9L^ 5
ûÙÎ-ÁÕÖ
$
0Q
F9L^ 5
ûÙÎ-Á$æ
rD
3>V
mn
(&)
% F9L^ 5
1xó@øóô8–
„›–¬’
;RQ*
rÖûÙ
%
s”•cô
D¨©
FBHI*
óô
3>V
Õ
Ö
$
eDÍéørD
3>V
mn¬–ŠŒùûÙ
IÝ
F9L^ 5

/>;3
P¶$ª
%
ǹ
sžd­C°
DA±“Ö–cd:ٖ
Œ$
I8F
rŽaÄ
(()
$
s”•xó
BC
ªä–óô8ŠŒùûÙ
IÝ
I˜Ñ

$
þég2
I8F

$
òèD@
b€–ó
ôcdŠ‹Ÿ i%
%
ӟèh
$–óô
žŸ èDø
;RQ*53>V
lŸ ./¬’
%

˜™
#!
>%€ÓÔab&”•5-/0\ɏ
3>V
a>ûÙFsÝRQsŽ
C<>
­®ÿ3LRId+
¨¾ÝÁ×
%

{|}~
#
( )!
ÕÖ×ó
*
؝Ù
$
ÚóïïA
*
ÕïA
$
•}Û
,
Ä,ŽÊ
°:ٓ֌֖cdžŠ‹
(X),
$,,êø‚
ƒ
$ *$$#$**!#)&d
( * )!3O/BS W$ 3D5F.+JRJ16T$ 8JSSJaUJ3,31PJOBH?P.P.7J-?-PJeJP6
*4%**
t
)4
¥t
&
v
*$&
o
%
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
\.Dd)4$:KKUB!&
XUD6$ *$&
.QKBBSK.Q6(7:.*(+,(&4?O+2(X),XVPO1.HO?R/?-.D$ *$$)$ (%
!*=)# *)%d
( ) )!
!:7
$

$
ôê
$
ÿ
,
ŽÊ,ê,‘”•—˜
(X),
Tp$
C,
$ *$$#$ *&!)#($d
( & )!F?De.RKB1 W$ F.DPBc$ 96ORKP?S 9$ BP?D,3K6KPB/?PJ-K-RBB15
J1A.QP.P?D?1PJ.7JS?1PKJ1 SJBP?R6HD?1PK(X),X;UPR$ *$$*$)*
!)#&#d
( )!C?HBPJ3$ Y?ADJ?9$ IRJK.DJC$ BP?D,31PJ5?1S HR.5.7JS?1P?-5
PJeJP6.Q6(7:.*(+,AB1UKeBABP?]DBK?1S BQB-P.QPOBR/?DPRB?P5
/B1PJ1 ]J.D.AJ-?DK6KPB/K(X),` ..S ( # )!C?HBPJ3$ Y?ADJ?9$ I?ZZ?1JI,31PJ5?1S HR.5.7JS?1P+?PBR
K.DU]DB?-PJeJP6.Q6(7:.*(+,AB1UKeBABP?]DBK?1S BQB-P.QPOBR5
/?DPRB?P/B1P(X),X3ARJ-` ..S ( % )!
>²½
$
çJ¦
$
ÛÚÜ
$
ÿ
d
¯SŽÊAB€ŠŒÕÖ
”•
(X)d
Pqø,q
$*$$)!)#4)d
( ( )!6(7:.*(+,0&9(>(% G,B7PR?-P?1S JPK-OB/J-?D-.1KPJPUB1PK(X),
9.DB-UDBK$ *$$#!#4$&4d
( 4 )!CJX$ W?JN$ >BB-BX9$ BP?D,9.DB-UD?R/B-O?1JK/.QOU/?1
;RQ* ?-PJe?PJ.1 ?1S SBAR?S?PJ.1# R.DB.QKBaUB1PJ?DHO.KHO.R6D?5
PJ.1 ]6HR.PBJ1 [J1?KB?SJ-WJ.D9BS$ *$$%$&*
!*#%4%d
($)!3AUJD?R5YBDQJ1 :$ G.HBZ5W?RBR?` $ FBR1?1SBZ59U1.Z>,8BDB-PJeB
B1O?1-B/B1P.QDJHJS HBR.7JS?PJ.1 J1 HD?K/?/B/]R?1BJ1 P+.B7HBR5
J/B1P?D/.SBDK.QDJeBRRBAB1BR?PJ.1# H?RPJ?DOBH?PB-P./6?1S ?-UPB
<&
?S/J1JKPR?PJ.1(X),FBH?P.D.A6$ 44#$*&!)##%d
()!GJ1 N8$GJ1 -?1-BR-BD?H.HP.KJK/BSJ?PBS ]6?-PJe?PBS /?-R.HO?ABKJK1JPRJ-.75
JSB5SBHB1SB1P(X),WJ.-OB/CO?R/?-.D$ *$)$(#!*#*&*d
(*)!c?1A9:$ c.]?6?KOJ3$ M?[?]?6?KOJ;$ BP?D,8-?Q.DSJ1A.Q
cB?H P.POB?-PJ1 -6P.K[BDBP.1 -.1PR.DKPOBQU1-PJ.1 .Q;RQ* ?K
[B6RBAUD?P.R.Q-6P.HR.PB-PJeBHO?KB* AB1BK(X),;?PD3-?S 8-J
E83$ *$$&$ $!%# *$&#d
())! .`R/?1 FX$ _O?1AF$ >J11?3,IDUP?POJ.1B# .eBReJB+.QJPK
HR.PB-PJeBR.DBK$ /B?KURB/B1P$ ?1S ]J.K61POBKJK(X),9.D3K5
HB-PK9BS$ *$$4$ )$!=*# d
(&)!W?JRS G$ YJ1[.e?5c.KP.e?3T,TOB-6P.HR.PB-PJeBR.DB.QPOB
cB?H5;RQ* H?PO+?6(X),3R-O T.7J-.D$ *$$(!&#*&,
;BGFD @A-AB.+@N.F-B.P??J?RB@J?NBE-RBIJE@,>(07%,(.6*#:(3( @A
1?KY* R?/I-AF.BI,?RC-A.I,
$*
$ _F3;GJ50U?1
*$)
$ MV:XJ15QB1A
&
$ X:;F.1A5P?.
&
$ b:;F?J5DJ1

$ M3;I3J5HJ1A
*
!
!dV+(%& $*.>(&7(%5!0/#*+) A%804?T>%5+%4(.& 60&40*$ V+(%& <09(7%5=&(>0*2(4?$ V+K:.+ )$$($ 6:(&%
*d!0/#*+) A%804?T>%5+%4(.& 60&40*$6:(&020@7%90,?.8<09(7%5A7(0&702[$0N(&) =&(.& <09(7%56.50)0$U0((&) $$$$$6:(&%
)dA4%40Q0?L%O.*%4.*?.86%*9(.>%27+5%*#(20%202$ 6:(&% SI8.*9 60&4*08.*D&40*&%4(.&%510%54: R020%*7:$
V+/%(1.23(4%56@%27+5%*#(20%202$ 6:(&020@7%90,?
.8<09(7%5A7(0&702[$0N(&) =&(.& <09(7%56.50)0$ U0((&) $$$)%$ 6:(&%
&dU0((&) =&(.&C0&(+2$:%*,%70+4(7%5-07:&.5.)?L49$ U0((&) $$%#$ 6:(&%
dQ0?L%O.*%4.*?.8U(.%74(>0A+O24%&702%&9 R02.+*702=4(5(K%4(.& .86:(&02010*O%5<09(7(&0+&90*<(&(24*?.8T9+7%4(.&$
D&24(4+40.8<%40*(% <09(7%$ 6:(&020@7%90,?.8<09(7%5A7(0&702[$0N(&) =&(.& <09(7%56.50)0$ U0((&) $$$$$ 6:(&%
(4LIBE-RB)!6L[?RB.P?# T.J1eBKPJA?PBPOBHR.PB-PJeBBQB-P.QB7PR?-PKQR./6(7:.*(+,0&9(>(%!*
L
*
5J1SU-BS FBHI*
-BD.7JS?PJeBKPRBKKJ10UR6$ ?1S B7HD.RBPOB?1PJ.7JS?1P/B-O?1JK/.Q*
L
*
5J1SU-BS
FBHI* -BDK?1S POBJ1PR?-BDUD?R>L8 DBeBD+BRB/B?KURBS ]69TT?KK?6?1S Y<`F5Y3QDU.RBK-B1-BKP?J1J1A?KK?6dTOB?1PJ.7JS?1P5
RBKH.1KBBDB/B1P!3>V5GU-JQBR?KB?-PJeJP6+?KPBKPBS J1 FBHI* -BDKKP?]D6PR?1KB-PBS ]63>VRBH.RPBRAB1BdTOBQDU.RBK-B1-BaU?1PJP?PJeB
>T5C<>+?K?S.HPBS P.SBPBR/J1BPOB/>;3B7HRBKKJ.1K.QAB1BK-.1P?J1J1A3>VKBaUB1-BJ1 FBHI* -BDKd8?IG/B#TOB-BDeJ?]JDJP6RB5
SU-BS$+OJDBPOB>L8 DBeBDJ1-RB?KBS ?QPBRFBHI* -BDK+BRBPRB?PBS ]6F
*
L
*
dYJQBRB1P-.1-B1PR?PJ.1K.QD6J/HR.eBPOB?].eBRBKUDPKd3QPBRFBHI* -BDKPR?1KB-PBS ]63>VRBH.RPBRAB1B+BRBPRB?PBS +JPO SJQBRB1P-.1-B1PR?PJ.1K.Q-BDUD?R3>V?-PJeJP6-.UDS J1-RB?KBJ1 ?-.1-B1PR?PJ.15SBHB1SB1P/?11BRd:1 ?SSJPJ.1$ POB/>;3B7HRBKKJ.1K.QRBAUD?P.R6AB1BKIIVKBaUB1-BJ1 FBHI* -BDK+BRBUH5RBAUD?PBS J1 ?-.1-B1PR?PJ.15SBHB1SB1P/?11BR]6*
L
*
5J10URBS FBHI* -BDK]6RBSU-J1APOB>L8 DBeBDdBS P.POB?1PJ.7JS?1PSBQB1KBK6KPB/?KK.-J?PBS +JPO JPKBQB-P.Q?-PJe?PJ1A;RQ*53>VH?PO+?6J1 FBHI* -BDKd
(Z?D W@EFI)!6(7:.*(+,0&9(>(% RB?-PJeB.76AB1 ?1PJ.7JS?1P5RBKH.1KBBDB/B1P OBH?P.HR.PB-PJ.1
F@.#)a(XbOR[R,,()(

€-0
!
‚‚
#
*$*%**
t
)4
¥t
&
v
*$&
o
%
p
!!!!!! ! ! ! ! ! !!!! ! ! ! !
\.Dd)4$:KKUB!&
XUD6$ *$&