免费文献传递   相关文献

Simultaneous characterization of two types of major active components in Kushen by high performance liquid chromatography coupled to multi-stage mass spectrometry

高效液相色谱多级质谱联用法同时鉴定苦参中的两大类活性成分



全 文 :¡éJj}Q‘¢[Q¹“©Z9ÕÔO’
r[=£ªÚ6
3}}
#
E/`
#
¦±²
!
!
\™>¬5HF¬ýèj¬C
#
\™ BR
QRMMLN
$
”;
%!

&
Z9ԝ6O’r=£ª¤^[EG£[Ú6
$
ãÌtÑG;¨´
%
–—
,
ғ¡éJj
}Q
<
‘¢[Q¹“ùÓ
!
ì)»
#
¡ˆ“Xš¬[,6“ˆ“ÈGª‘¢½tnj
!
i7«()LØ6C2>C2

˜™
,
Z
9Õԉ
_X
^ÄÌ
!
wRY
ãÌtÑ
XY
¨´
!
>CO’rtœtâÑ-cùtâãÌt[[Q‰›Óëîˉ8
0Ñ<ñ

˜š
,
#0ŒêO’Ú6[RNÕÔÛԉs¨

$
›œ
%!

&
ãÌt
&
¨´
&
¡éJj}Q‘¢[Q¹“
$.8C<=1
)
%&
01ÕÔ
$
8…$f
%!XMRMM`XNMML
$
†‡Eq
%!
­æ
.
k£‹Ç=Ü
/
øùk£­u
$XMM`d+M`QM_<
MMX vXMM`d+M`QRRôÈRÁK¡÷:‚uv
$3XMNMY`Q%
$
ˆ€>‰
%!
!
4Į
!
‚&³Ù‘Ù6ÇÌÿ~ ?GÇÌHå
G¤_‡ƒ„
!A(&,$ML\R%NNXMNL`Y!-!!
RNÕÔZ|ÇÁL…Ûr¤^[EG„£
[Ú6äÐhrÇÌ[s¨ƒ„[­-Dg
|

T胄£‘}CYZªÑ[Ú66ÑBCµ
$Ñ6…©
!
îË6ÕÔ
R(

)|ƒ„Xš„
9P
!
nY®•²B…©[99\“
!
_ÃÀì

O’äùøñÕÉÌO’
A.>:.+# I=#-<<,
>2f
[6/ì
!
yèóF/ý
#

#
®Xàé
X(
!
ª
Ú6‚&êãÌtÑG;¨´
Q(

N•©
 s:[Ž]
!
ãÌtª^ÄÌ¡(o_>Út
&

!
¨´ª^ÄÌN•Ž]G;s:
!
¡(ob
>ÚB

ü#£[¤^[EG
!
Ívh‰
•O’Ì[s¨ƒ„ŒÀ&•¾|ª^ÄÌ
_
£ƒ„Ò“
.8C<=1
)
©BC‰Z9ÕÔO’r[
=£ªÚ6[6…©
!
>80‰ªr=¢ª
âãÌt[[Q‰›Óë

!
ÁÂ
>*&()2RRMM
¡éJj}QHå
$
l­é‹Œ˜

%!
ýJ**J”&à
!
[Qê
J))*$) CeT(G$
+8
V&40
ˆ“s
!
Ðè1¶Nˆ“¬
$ -1;% $

J))*$)
[Q˜
%
Š.
#
”•ê}QO
$
k­{<˜
%!
ýŠ 
bê}QO
$

1*I$
˜
%!
¡O_;n
=&ŸO_Hå
$

=&V/%(
˜
%
O’ÇÁØn9,RDž
!
ÍôÈ£_rÇø
_iN?_H®íSÄÕÔ

^O’t
$%
Ñ
^ñŒt
$(%
Ønr­Ç>ãÌÜ>”Ô²
$

üý
%&
†ùt
$!*%
ÑtœtØn‡òÿ@zú
Çøùè&˜
$
r­é
%!
ªÇÀ,>
,Xq<
”
sO’´
$!#%&
ñÔt
$!)%&
O’t
$#+%&
ñŒt
$#!%&
¨ˆ•
$#)%&
ñÕ¨3´
7$$! %&

;
$$%%&

C$$&%&
O’´
$$%&
ùO’´
$$)%&
O
’½
$$*%&
M”O’½
$%+%
ÑGO’´
$%!%
ê£
¦§Üµ$h

À,>O(Í
.8C
6Œmh
`Nh
_

#
…©
# !^
}Qâs
!d/%P$K-K2()5
RN
}QÚ
$_fY g
XLM II!LfM
!
I%
=Êj
,>
ê
MfMXLh
ýŠ _
ÏJ
!7
êŠ.

;(ýv
,M I)!\fQh7&XQ I)!
\fYh7& XN I)!RLh7&_M I)!XXh7&LM I)!
X_fLh7&\M I)!XYh7!
—p9’ê
RQ I)
=N
Mf\ IC-I)
SR
!
Ú¤
QL l!
î®·
RM
!
C
ýJ*
*J”&à
$ T>T%
ˆ%
R`M m_MM )I
ã®KQ
!
”&Ûzê
XXL!XNM
Ñ
QQL )I
# #^
´¹[Qâs
!
»
#
¡ˆ“Z9”&
!
¡Oº
ê‰â(ÿ

ˆ“¶N1O6Ñê
n _fL WU
$ n%! S_fL WU$ S%&
uK*¤(
,QLM l&
uK*
1O
,nR` U$ n%! SRL U$ S%&
*”xƒŠ1O
,
nXL U$ n%!SXL U$ S%&?
X
(Eê–(Ñ3ä(
!
–(=N
YM C-I)
SR
&
3(=N
XM C-I)
SR

O
pq4Æ
;)QRXM mR XMM
-XY\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
# $^
›î®[Qâs
!
»ˆ“Xš
!
ˆ“¶N1
O
_fL WU!
uK*¤(
X\L l&
uK*1O
RX U&
e
*”xƒŠ1O
QM U&
–(=N
L C-I)
SR
&
3(
=N
M
C2>ÏJ
RM
!
C-I)
SR
[=N?҈
“¬
!
h‰i·4Æê
XMh mLMh
# %^
qç>ÏJ[ÜÝ
!
P$O’ÇÁVo
$_M
v
%MfR *!
“
LMh
”•_Ô•
L IC
·Cr
!
Pk
ܤŸÛµ$
QM I)
ò%Be
!
“
LMh
”•_ƒ
†\E[k·

ÏJˆá¾$_óJEêO’qç
>ÏJîË¡éJj}Q‘¢[Q6


!X
¢ªâ[O’ãÌt
$
tœtâ
,
tœt
&
-c
ùtâ
,
†ùt
%
[C2>ÐÜÚ
MfX *-C
SR

•ÏJ
!
“?I)›î®
!
îË1¶N[Q6

$
0Œi‡,
³O’qç>[»¡8ˆ“=fÊf
R
*¨
K
!
²è[ãÌtÀ]»ˆ“Xš¬&”&h
!

´‘(]¡ˆ“Xš¬ˆ“^
!
g(b*]»ˆ“
¬›ˆ

]»ˆ“Xš¬
!
N‰,6“ˆ“È
=n
.(
n
®
!
£‘(^ÄÌw½KŠ(u¡[
=n.n
\Q(
n
ˆ“
!
*iê,6“ˆ“i=ÊjrýŠ 
$T->%

!
ãÚ
=n.nT->(
n
ˆ“[0Œ

»
#
¡ˆ“pq¬[,6“ˆ“Èî|jîˉý
¢[QG„¢[Q[6

ì)C2>G7«n
j
!
ÐÕԉ
_X
^ÄÌ
!
j‰[KQÑ[Q()
ʼ
R
f
R!
O’µ$Ì[»
$>%#
¡
$7%
8ˆ“=f
$ !^
ãÌtª^ÄÌ[ÕÔ
!
O’r[ãÌt‚
&ꋌ,½ªãÌt
!
n‚&wx
_
ª
!
6ÑêO
’tâ
#
tœtâ
#
-cùtâэŽùtâãÌ
t

£ƒ„ì)O’ãÌt]»ˆ“Xš¬[‰›
±y
!
ÐÕÔ
RX
O’tâ
!R
tœtâÑ
Q
-cùtâãÌt

O’ãÌtª^ÄÌ[~£ã®IJ]
XMY
)I
g^
!
hO’¨´ª^ÄÌN‰]
XRM )I
g^
èã®IJ®
!QXM )I
L
QNY )I
g^bŽ]YZ
?([IJ

N#Ÿ‘^ÄÌ
$ b!!! !$! !( b##
êãÌtª^ÄÌ

ªr^ÄÌ
! (! !)! !*! #+!
#!
ì)À,>C2/Ôê^O’t
$%!

Œt
$(%!
ñÔt
$!)%!
†ùt
$!*%!
O’t
$#+%!
ñŒt
$#!%
ì)C_¢¸C2>Ñ7
«rO’ãÌtª^Ä̉›½t[80
_!Y(
!
*
€TO’tâãÌt[ý¢½tZ9yèYZŠ
([
;)QRLM!R_N
ˆ“G
=n.S.
X
O(
n
ˆ“
!
ªrO’tâãÌt[>^Ì[|¢[QyèŠ
(u¡[ýÿaĈ“
X=n.(
n
!
>nª,6
“ˆ“È[ý¢½ty衊([±yˆ“
=n
.S.
X
O(
n
Ñ
=n.SR\(
n
!
s^Ì[
X=n
.(
n
ˆ“Š(jC„,
!
ìyèŠ(u¡[v_È

ì)_¢80
!
9‘^ÄÌ
$ b)! !!! !(! !)! #+!
#!! ##
êO’tâãÌt
!
ªr^ÄÌ
% b(
êO’
tâãÌt[>^Ì

^ÄÌ
&
[|¢[Qy衊([
X=n
.(
n
ˆ“
!
ý¢[QyèsÈ
;)QX_\ =n.S
.
X
O(
n
ÑòÈ
;)QX_N =n.SR\(
n
!
Z9Ϗ
;)QRLM!R_N
ˆ“
!
êO’tâ[>^Ì
!
Øì)

\(
9‘ªê^ñÔt
$&%&
^ÄÌ
%
|¢[
Qbyèuò[
X=n.(
n
ˆ“
!
ý¢[Qyèv

;)QXYQ =n.S.
X
O(
n
!
]v_È[s¨_
!
œyè
;)QX_Y =n.S.
X
OSR\(
n
Ñ
;)QX_L
=n.S.
X
OS.
X
O(
n
ˆ“
!
>9&ªêO’tâ
[>^Ì
!
Z9\ès
!
î|j9&ªê^ñ
•
$%%
N(

^ÄÌ
!(!##
,6“ˆ“È[ý¢[Qyyè
;)QRLM! R_N
Ñ
=n.S.
X
O(
n
ˆ“
!
nª]Åj
Ú_ƒ>^Ìяs^ÌAâ
$ Y mQM I) %
ü
ò
!
i^ÄÌ
!)! #+! #!
‡‚^Ì[Aâ9’„
ê–
$LM mYQ I)%!
>9‘¼äO’târ[
‚^Ì

0Ä7«nj
!
9‘¼6Ñêñ t
$!(%
`(
ѐ‘t
$##%
RM(

^ÄÌ
$!)!!!
Aâ9’+h
!
>n|¢[Q
X=n.(
n
ˆ“Š(jC„,
!
ý¢[QyèŠ(
-QY\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
!!
¼
R!
ÍÕÔ[O’µ$Ìr[^ÄÌ
?/f
!
3
ã®
[)I
,6“
ˆ“È
‘¢[Q
$h

%
^ÄÌMP
»ˆ“Xš
!
L:RR XR_!QXX XNL
=1
X
XNL(,X\M$RMM%!XLQ$YX%!XX`$\%!XXL$RN%!RQ\$\%
u’G¨´
RY(
# L:NL XRM!QXN!Q\Y Q\R
=1
X
Q\R(,QRL$QN%!X`\$RQ%!XQL$RMM%!R\`$_% Xq<#B5%/KB&<0/K$)2#/#4I/&
RQ(
$ Y:QX XR_ XNR
!=1
X
XNR(,XY_$\_%!XYQ$RMM%!X_Y$`%!X_L$Y%!XXX$XM%!
XXR$__%!XRN$XM%!R`Q$XR%!RLM$R_%!R_N$XY%!RQ\$N%!RQY
$R\%
L
/
!`
/
<
ýsO’t
_(
%
\:QR XM_ XNR
!=1
X
XNR(,XYQ$RMM%!X_Y$Y%!X_L$RL%!RNM$RX%!RLM$Q%!
R_N$Q%
^ñ•
N(
& N:XQ XM_ XYL
!=1
X
XYL(,X_N$\Q%!X_\$RMM%!XXM$\%!XML$X`%!RLM$Q%!
R_N$X%!RQ\$_%
^ñÔt
\(
R\:`` XMY XYL
!=1
X
XYL(,X_N$NQ%!X_\$RMM%!XQQ$_%!XXM$RQ%!XR`$_%!
XMY$RY%!XML$LQ%!R\\$L%!R\Y$\%!RLM$`%!R_N$_`%!RQ\$RX%!
RQY$RL%!` N$L%
^O’t
R%
( XQ:LQ XMY XYQ
!=1
X
XYQ(,X_L$RMM%!XX\$_%!XMQ$Y%!R`L$\%!RLM$XL%!R_N
$X%!RQN$RX%!RQ\$_%!RQY$L%
^ñŒt
R%
) QM:\N XMY XYQ
!=1
X
XYQ(,X_Y$NN%!X_L$N`%!RYY$Y%!RY_$RMM%!RLM$RY%!
R_N$XM%!R_Y$`%
`
/
<
sñŒt
_(
*
QL:NY XMN XYR
=1
X
XYR(,X_Q$`M%!RY_$X_%!R_Y$QM%!RR_$RMM%!` Y$QQ%
“”ct
_(
!+ QY:LY XMN XML
=1
X
XML(,RYX$XM%!R_Y$RMM%!RMN$NM%!` \$RL%!LN$RR% ?<
”stœt
_(
!! _R:YR XMY XYL
=1
X
XYL(,X_\$_`%!XML$\%!RYN$N%!RLM$RR%!R_N$R\%!` N$X%
ñ•
_(
!#
_Q:LY XMY!QQX _LQ
=1
X
_LQ(,QX`$RMM%!QMQ$YR%!R`\$_%!R\`$R\%!R\\$XM% Xq<
”sO’´
R%
!$ __:Y_ XMY QMQ
=1
X
QMQ(,X_Q$RMM%!XMY$R%!R\`$R%!R_N$R%!RXX$R%!` _$R%
Š‹“”ct
_!RR(
!% _Y:LR XMY L\!=1
X
L\\(,__L$RMM%!XNQ$YM%&=1QL\+
XNQ(,XYL$X%!XLL
$Q%!XLQ$RMM%!XX\$_%!XXL$Q\%
!\<#B5%/KB6&$E/)(<\XM(
!& _\:`L XMY!XLM!QMN LYQ
!=1
X
LYQ(,_N`$Y%!_QR$RMM%!XY`$YM%& =1QLYQ
+
XY`(,
XL_$RMM%!X_R$QM%!XQ\$YQ%!XRQ$RN%!RQ\$X\%!RM\$RM%
!

O[\<#B5%/KB0/6&$E/)(<\L(
! _`:M` XMY!X_N!QXN LYQ
!=1
X
LYQ(,_QR $RMM%!XY` $LM% =1Q LYQ
+
XY`(,XL_
$N\%!X_R$XR%!XQ\$L`%!XRQ$RMM%!RNR$QL%!RQ\$QN%!RRN
$RY%!RM\$`%
Z^ÄÌ
!&
!( LM:X` XMY X_L
!=1
X
X_L(,XX\$RMM%!R\_$XX%!RYX$`%!RLM$RL%!R_N
$R\%!RQ_$\%!
ñ t
`(
!) LM:LM XMY X_`
!=1
X
X_`(,X_\$NM%!XQR$``%!XRN$QM%!RLM$RMM%!R_N
$__%!RQ_$QX%!RRX$_Y%
ñÔt
R%
!*
LL:LY XM_ X_L
=1
X
X_L(,R_N$XX%!`N$RMM%
†ùt
R%
#+ YR:_` XMY X_`
!=1
X
X_`(,X_\$_L%!XQR$RMM%!RLM$QR%!R_N$`_%!RQY
$XX%!RR_$XY%
O’t
R%
#! YQ:MY XM_ X_!=1
X
X_\(,X_L$RMM%!XX`$XM%!XX\$`%!R\`$QX%!RLM
$YL%!R_N$LR%!RQN$RX%
ñŒt
R%
##
YN:`R XM_ X_!=1
X
X_\(,X_Y$X%!X_L$X%!XX`$X%!R\Y$_%!RLM$_%!
R_N$RMM%
‘t
RM(
¡ˆ“Xš
#
L:`Q XRM!QX_!QNY QY`
=1
X
QY`(,QLR$Q%!Q_R$X%!XM\$RX%!RYR$RMM% Xq<#B5%/KB&<0/K$)2#/#4I/&
RQ(
#$ \:_R XRM!QXM!QNY L\`
!=1
X
L\`(,QX\$X%!XNL$RMM%!XL\$Q%!XRQ$X%& =1
Q
L\`
+
XNL(,XL\$RMM%!X_R$X\%!XRQ$XM%!RLQ$L%!RQL
$RL%

9
RL(
#% N:LR XRM!QXY!QNY QY`
!=1
X
QY`(,Q_R$RMM%!QQ\$Q%!QXL$XN%!XYX$_%!XM$L%!RYR$X%
!LN[\ Q! Q<5I(2#B&$&B&(<6&$E$)/)(
RX(
#& `:XN XRM!XNN!QNY LYL
!=1
X
LYL(,X\R$RMM%!X_Q$Q%& =1Q LYL
+
X\R(,XLY
$L%!X_Q$RMM%!XX\$XR%!XRX$\%!R``$R\%!RQL$RX%
!Q!\!_q<2%#B5%/KB6&$E$)/)(<\<
V%I(E(%/05([Q! \! _q<2%<
#B5%/KB6&$E$)/)(<_q05(
R_(
-_Y\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
Ѽ
R!
ÍÕÔ[O’µ$Ìr[^ÄÌ
?/f
!
3
ã®
[)I
,6“
ˆ“È
‘¢[Q
$h

%
^ÄÌMP
# RM:RR XXN!X\M!QNY LYL
!=1
X
LYL(,X\R$RMM%!X_Q$L%&=1QLYL
+
X\R(,XLY$_%!X_Q
$RMM%!XX\$XL%!XRX$RX%!R``$XX%!RQL$RR%
Z^ÄÌ
#&
#( RQ:_L XRM!QX_!QNY QY`
!=1
X
QY`(,Q_R$RMM%!QQ\$Q%!QXL$XN%!XYQ$X%!XYX$Q%!XM$_%!RYR$R%
Z^ÄÌ
#%
#)
XM:MQ XRM!QX_!QNY QLQ
=1
X
QLQ(,XLR$L%!X_\$_%!XQQ$RMM%!RR`$RR%
¨ˆ•
R%
#* X\:_\ XRM!XYN!QYN L\!=1
X
L\\(,LM_$X%!XNQ$RMM%!XYN$Q%& =1QL\+
XNQ(,XYN
$RMM%!XLL$`%!XLR$_Y%!XXQ$XX%
!G$&BG/0)<\RN(
Qq<
I(2#/KB5$5a()<\$+ QM:_` XRM!QRM!QYN L\!=1
X
L\\(,X`Q$L%!XNQ$RMM%!XYN$L%& =1QL\+
XNQ(,XYN
$RMM%!XLL$\%!XLR$Q`%!XXQ$RL%
Z^ÄÌ
#*
$!
QX:XN XRM!QX_!QNY QQ`
=1
X
QQ`(,X_L$RL%!XQ\$Y%!XR`$RMM%!R`Q$L%
ñÕ¨3´
7
R%
$# QQ:RX XRM!QXX!QNY XY=1
X
XY\(,XLX$RMM%!XQ_$L%
•–œ¨û
R\(
$$ QQ:`Q XRM!QQM _Q!=1
X
_Q\(,_R`$RM%!_M`$RMM%!Q`Q$_L%!QYN$LX%!QYL$QL%!
QR_$LX%!QRQ$LM%!XN\$NX%!XYR$\M%!R_`$L%


L!RX(
$% Q_:MN XRM!QQX _LQ
!=1
X
_LQ(,_XL$RQ%!_XR$XR%!QMQ$_%!X\L$XX%!R\\$RMM%!
R_`$RL%

;
R%
$& Q_:NQ XRM!QQM _Q`
!=1
X
_Q`(,_XR$X_%!_RR$L`%!Q`L$RM%!XYR$RMM%!XR\$L%!
R\\$RN%

C
R%
$
QY:QM XRX!QXN _Q=1
X
_Q\(,_R`$Q%!X\L$RN%!RYR$RMM%
O’´
R%
$( Q\:LR XRM!QRX!QNY XNQ
=1
X
XNQ(,XYN$RM%!XYL$R%!XLL$RMM%!XL_$QM%!XQ`$\%
¡ÿñû
L!R`(
$) Q`:`Q XRM!QQM _XQ
=1
X
_XQ(,_ML$R%!Q`L$R%!QRQ$R%!XYR$RMM%!RYR$RN%
ùO’´
R%
!# _Q:YR XRX!QXN _LR
=1
X
_LR(,_R`$`%!QR`$RQ%!QMR$RMM%!R\L$L% Xq<
”sO’´
R%
$* __:QM XRX!QRY!QNN _Q=1
X
_Q\(,_R`$_%!X\L$XX%!RYR$RMM%
O’½
R%
%+ _\:X` XRX!QQM!QNY _XQ
=1
X
_XQ(,XYR$RMM%!RYR$R_%
M”O’½
R%
!& _\:` XRX!XYM!QM_ LYR
=1
X
LYR(,XY\$RMM%&=1QLYR
+
XY\(,XLX$RMM%
!

O[\<#B5%/KB0/6&$E/)(<\L(
%!
_N:`N XRX!QXN!QNY _Q=1
X
_Q\(,_ML$RX%!QRQ$NM%!XN\$RMM%!XYR$RL%
GO’´
R%
! _`:MR XRX!XYM!QM_ LYR
=1
X
LYR(,XY\$RMM%&=1QLYR
+
XY\(,XLX$RMM%
Z^ÄÌ
!&
%# L`:`R XRM!QRM!QNY __L
!=1
X
__L(,XNQ$RMM%& =1QXNQ(,XYN$RM%!XLL$RMM%!XL_
$QL%!XQ`$_%!XRR$_%!R_L$_%!RQ\$_%
„cùã—w
L!R`(
!!
?
,R%
ÍC2>C2ÕÔ

u¡[v_È
!
*Ÿ‘ªêO’tâãÌt[s

!
Ø0Ä7«
_(
*9&¼ê
L
/
!`
/
<
ý
sO’t
$$%! `
/
<
sñŒt
$)%
Ññ•
$!!%
^ÄÌ
!+
,6“ˆ“È
;)QXML
[ý¢½t
yèsÈ
;)QR_Y
ˆ“
!
i7«4ø
_(
|>
!
½t
;)QR_Y
*iä
\Ñ
`‘‰äã
!
N#
9‘ªê
?<
”stœt
$!+%!
Օtœtâã
Ìt

^ÄÌ
*
[,6“ˆ“Èê
;)QXYR !
ªý¢
[QyèsÈ
;)QX_Q =n.S.
X
O(
n
&
^ÄÌ
!$
[,6“ˆ“Èê
;)QQMQ!
ªý¢[QZ®äã
‰sÈ
;)QX_Q =n.S
X
.
_
O
X
(
n
!
>9&=F]
6Ñv_ÑvŠ‹s¾äã‰jZ[Z+

î|j
i†ùt
$!*%
[‰›½tCƒ
!
~ß9‘¼ê“
”ct
$*%
_(
#
Š‹“”ct
$!$%
_!RR(

^ÄÌ
*!!$!!*
Օ-cùtâãÌt

$ #^
¨´ª^ÄÌ[ÕÔ
!
£ƒ„ÐÕÔK
XY

¨´ª^ÄÌ
!
wx
Y
ý-¨´
! Q
Co´
! ý-¨´•
! R
¨´•
! Y
G¨´
! X
ã—
ûª¨´Ñ
R
´­»´

ªrè
N
´7wÑ
R
H7w
!
´7wê\èý7
V%I(E(%/05(
s:
$

D
K<
567
n

DK<
w7
%
[^ÄÌ
!
¼T][Q_[±
y½têäãŠ(u¡[
=S.SX`_(
S
ˆ“
!
H
7wê567w
!
iä㡊([
=S.SRYX(
S
ˆ“

¨´ª^ÄÌ[ÕÔäì)»
#
¡ˆ“Xš
¬[‰›;9&[

ì)ã®IJKQ
!
¨´ª^ÄÌ]
XRM! QXM
L
QNY )I
g^Ž]YZ?([IJ
!
>9‘^ÄÌ
! b#! !#! !% b!! #$ b%#
ꨴª^ÄÌ

ì)7«
RX(!
ý-¨´Ñªj\[Co´æ
-LY\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
äã|Ô[1âM^
!
>[Q±y|>

‚&¼T
ê

-7‰›
!
äãŠ(J¡[
>
-L
7
-½t
ˆ“

]»ˆ“Xš¬
!
Ð
7
-_[
Xq

.
L
O.
Q
9
!
ý¢[Qr
1
n
ˆ“
$
,6“ˆ“ÈEMG
;s
%
[Š(X¡•
R!Q
>
n
ˆ“
&
Åg
!
Ð
7
-_[
Xq

O.
9
!
ý¢[Qr
R!Q
>
n
ˆ“[Š(¡•
1
n
ˆ“

]¡ˆ“Xš¬
!
Ð
7
-_[
Xq

O.
9
!
ý¢[Q‚&äã
R!_
>
S
L
R!_
7
S
ˆ“
!
]#s¨_
!
5
>
-
L
I‰[bä
O.
9
!
R!_
>
S
ˆ“Š(¡
•
R!_
7
S
ˆ“
!
5
>
-
L
Iöè‰
O.!
E
R!_
7
S
ˆ
“Š(¡•
R!_
>
S
ˆ“
&
Ð
7
-_[
Xq
I‰[ä
.
L
O.
Q
9
!
ý¢[Q‚&äã
R!Q
>
S
ˆ“
!
hªj[
R!Q
7
S
ˆ“Š(u,

ì)_¢nj
!
9&^ÄÌ
#! !#! #)! $!! $! $)! $*! %+! %!
êý-¨´ÑC


ªr^ÄÌ
!#! $!! $! $)! %!
m À,>
C2/Ôê
Xq<
”sO’´
$!#%#
ñÕ¨3´
7
$$!%#
O’´
$$%#
ùO’´
$$)%
ÑGO’´
$%!%!
Œêý-¨´
!
ª
,U
[~¡IJÈ]
XNM
)I
g^

^ÄÌ
#)! $*! %+
Í À,>C2/Ô
ꨈ•
$#)%#
O’½
$$*%
ÑM”O’½
$%+%!
êCo´
!,U
~¡IJÈ]
QYM mQ`M )I
^ÄÌ
#
[9Àü¬
!
]»ˆ“Xš¬
!
sÈê
;)QXQL
R!Q
>
n
ˆ“
!
h
;)QQRL 1
n
ˆ“Š(ª5
!
9&
7
-
_[
Xq

O.&
]¡ˆ“Xš¬
!
sÈê
;)QRYR
R!_
7
S
ˆ“
!;)QXMR!_
>
S
ˆ“Š(ª5
!
>
7
-_
[
Xq

O.
[Z9
!>
-
L
I‰[ä
.
LF
O.
Q
!
î|jì)7«*9&ªêý-¨´
Xq<#B<
5%/KB&<0/K$)2#/#4I/&$#%
RQ(

ý-¨´•Ñ¨´•]¡ˆ“Xš¬[ý¢½
t
!
N䊋j\[
R!Q
>
S
!
R!_
>
S
!
R!_
7
S
ˆ“®
!
œy
è±y[
=S.SXN(
S
Ñ
=S.S__(
S
ˆ“
!
6
Ñê,6“ˆ“ÈE

-_[
O
Ñ
O
X
²
!
>#9‘^ÄÌ
#$ b#(!$$ b$&
êý-¨´•Ñ¨
´•

^ÄÌ
$%! $&
ÍÀ,>C2/Ôêý-¨
´•O•
;$$%%!

C$$&%
^ÄÌ
#%
Ñ
#(
|
¢[QÑý¢[Q|>
!
9‘¼êZ6G1ÿ

ý¢[Qry衊([Òâ[
=S.SX`_ S
XN(
S
Ñ
=S.S__(
S
ˆ“
!
Øì)6“·*9&
ý-¨´•[Z-_‰è|G;s
#
=s
Ñ|”s
>
-[
N
I

_‰G;s
!
>
n
L

I

_‰|”sL|s
!
Z
9
7
-_[
Xq
I

_‰|s
!
dè*iäã
;)QXMR!_
>
S
Ñ
;)QRYR
R!_
7
S
ˆ“
!
>*9ï¼
ê
L&B&(<6&$E$)/)($#%[#(%
L
\BRX(

^ÄÌ
#&!#
yèÒâ[sȈ“
=S.S
X`_(
S
!
\êý7
V%I(E(%/05(
w

w;î˄¢
[Q6
!
hÒâ[
=S.SX`_ SXN(
S
Ñ
=S
.SX`_ S__(
S
ˆ“
!
êý-¨´•L¨´•

Øì
)6“·nj
!
\ê‰è
X
s[ý-¨´•
!
À
è
X
s6Ñ]
>

7
-_
!
dè*iäã
;)QRQL
R!Q
>
S
ˆ“
!
>n
7
-_[sYi]
Xq
I

_KT
!
>9&¼ê
Q!\!_q<2%#B5%/KB6&$E$)/)(<
\LF
Q! \! _q<2%#B5%/KB6&$E$)/)(<_q<
V%I(E(%/05($#&[#%
R_(
!
Օý-¨´•

^ÄÌ
#$
Z^ÄÌ
#&!#
j!
!
ý¢[Qyè
Òâ[sȈ“
=S.SX`_(
S
!
\èý7
V%<
I(E(%/05(
s:
!
w;[„¢[QyèÒâ[
=S
.SX`_ SXN(
S
Ñ
=S.SX`_ S__(
S
ˆ“

ý-
¨´•[Z+]
>
-‰ès
!
]
7
-‰è”
s
!
dè*iäã
;)QRQL
R!Q
>
S
ˆ“
!
Ø0Ä7«9
&ªêý-¨´•
W40#()/&9$#$%
RL(

^ÄÌ
$$
ý¢[QyèÒâ[
=S.SXN(
S
Ñ
=S.S
__(
S
ˆ“
!
ì)6“·nj
!
\àꨴ•[Z+
_‰è
_
s
!
Ð
L!\!Xq!_q
I6щ|s
9
!
0Äyè
;)QXYR
R!_
>
S
ˆ“Ñ
;)QR_`
R!_
7
S
ˆ
“
!
n
R!_
>
S
ˆ“Š(£•
R!_
7
S
ˆ“
!
>9&ªê¨
´•O•
$$$%
L!RX(

G¨´˜_¢¸¢¨´][QËê_Ž]w£
[EÑ
!
¼Tê]¡ˆ“Xš¬
!
-u­‰›
!
h
»ˆ“Xš¬
!
-jCi¡ˆ“Xš¬7‰›

]£¦§ÕÔ[\è”s$ôs:[G¨´r
!
]¡ˆ“Xš¬yèÒâ[
=S.SRL(
S
Ñ
=S
.SQQ(
S
ˆ“
!
6ÑêE”sєs[äÌ

]»ˆ“Xš¬
!
N‰Òâ[
=n.SRL(
n
Ñ
=n.SQX(
n
ˆ“®
!
œŽ]

-‰›äã[½t
ˆ“
!
ğ
R!Q
>
n
ˆ“

)#
!
Ÿ‘^ÄÌ
!!!&!!!
#*!$+!$#
êG¨´

^ÄÌ
!
]»ˆ“Xš¬y
衊([
;)QX\M =n.SRL(
n
Ñ
;)QXLQ
=n.SQX(
n
½tˆ“
!
>yè,Š([
;)QRQR!Q
>
n
ˆ“
!
i7«4ø|>
RY(
!
9‘êu’G¨´
$!%
^ÄÌ
$#
]¡ˆ“Xš¬
!
Àè
=S.S
RL(
S
Ñ
=S.SQQ(
S
ˆ“
!
¼TKÒâ[G¨´
-YY\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
±y
!
Ø0Ä7«9&ꕖœ¨û
$$#%
R\(

^
ÄÌ
!&!!

#
¡ˆ“Xš¬[|
#
ý
#
„¢[Q
¼T|>
!
Ÿ‘¼êZ6G1ÿ
!

#
¡ˆ“X
š¬y¼TK‰¡Š([E
X`_
½tˆ“
!
¼.

R
ý7
V%I(E(%/05(
s:

Cw;³„¢[
Q6
!
€T»ˆ“Xšy衊([
=n.S
X`_ SRL(
n
#=n.SX`_ SQX(
n
ˆ“Ñ,Š([
;)QRQR!Q
>
n
ˆ“
!
¡ˆ“Xš¬ÀèsÈ
=S.
SX`_ SRL(
S
!
êÒâ[G¨´
!
0Ä7«*9ïê

O
GªG1ÿ
\<#B5%/KBV%I(E(%/05($!&[!%
L(
!
G1I%*iêO•
O
[
_q
I[”sG1:
Qq
I

^ÄÌ
#*!$+

ˆ“Xš¬yèÒâ[
=S.SX`_ SX`_(
S
ˆ“
!

V%I(E(%/05(
s:
!
w;[„¢[Qy衊
([
=S.SX`_ SRL(
S
Ñ
=S.SX`_ SQQ(
S
ˆ
“
!
êG¨´[ý7w
!
w;î|j*9‘êu’G
¨´GªG1ÿ
!
G1I%*iä
Qq
I[sÑ
_q
I[”s¸Q

>^ÄÌ
#*
Ñ
$+
9&ê
G$&BG/<
0)<\RN(
L
Qqa()<\^ÄÌ
%#
[,6“ˆ“Èê
;)Q__L!
ý¢[
QãÚ
;)QXNQ =S.SRYX(
S
!
ê,6“ˆ“E
M
R
6“567[äÌ
!
#½t
;)QXNQ
bä^Ä
Ì
$(
[,6“ˆ“È
!
î|jCƒ
;)QXNQ!
€T=
F‰›½t|>
!
>9&=FZ+|>

CZ+î
Ë6
!;)QXYN
ê
;)QXNQ
v¾a-²>
!;)Q
XLL
ê
>
-%䊋
!;)QXQ`
ä]
;)QXLL
s¨_


Øì)7«
L!R`(
>9&^ÄÌ
$(
ê¡
ÿñû
$$(%!
Â[567w
!
Õ^ÄÌ
%#
ê„cù
ã—w
$%#%!
Օã—ûª¨´

^ÄÌ
!%
]»ˆ“Xš¬byèÒâ[
=n
.SX`_(
n
ˆ“
!

V%I(E(%/05(
s:
!
Cw;C
„¢[Q6
!
yèv_½t
;)QXYL
ˆ“
!

s½t
;)QXLQ
ˆ“G
;)QXLQ
v™s½t
;)Q
XXL
ˆ“
!
Øì)7«9&w;ê
\<#B5%/KBB&<_qXM(
!
>9&ê
\<#B5%/KBB&<_qՕ´­
»´ª¨´

#ª^ÄÌiG¨´j!
!


-
_
X

Q
I)[´Š[Ž]
!
Í

-„­‰›
!
>äã[½t‘êZ+vM|L¸s:[ˆ
“

$ $^
tœtâÑ-cùtâãÌt[[Q‰›
Óë6
!
O’r[¨´ªÚ6[[Q‰›ÓëÑ
è÷K[<ñG80
!
ìãÌtªÚ6[[Q‰›
Óë80œY`Ÿì
!
n‘&•O’tâãÌ
t
Y(

>£ƒ„CO’t⏮[tœâÑ-
cùtâãÌt»ˆ“¬[‰›Óëîˉ<ñ8
0
!
êŸìO’ãÌt[[Q‰›Óë6µq’
“

ꉑ‡tœâãÌt[‰›
!
“À,>t
œtî˛î®1¶N[Q6
!
Z9C
?<
”s
tœt
$!+%
½t‰›îˉ9À
!
Êf
X
=F‰
›|>
!\Ñ
`y7€ã‘‰
!
tœ
t[ý¢[QÀè
>7
-½tˆ“
;)QR_N!
h
?<
”
stœt
$!+%
ý¢[QN‰
>7
-½tˆ“
;)Q
R_Y
®
!
Ϗ
>
-½tˆ“
;)QRMN
‡

=Fäã[
>7
-½th¥ä
;)QR_Y
ϊ
;)QR_N
ˆ“
!
*ii
RX
I[$ôsè‰

Ctœt[
;)QR_N
ˆ“³
„¢[Q
!
äã
;)QRXM
v™sˆ“

f
X!
tœt
$>%
Ñ
B<
”stœt
$7%
[Q‰›9À
-cùtâÑtœtâãÌt[01j!
!
>‰›Óës£|>
!\Ñ
`[‘‰ä
¼Òâ[‰›±y
!
Êf
Q
itœtâãÌ
t‰›YZ[ä
!
-cùtâãÌtN•
T
-[Ž
]
!
œi~Ú
T
-HJ½tˆ“
!
ü“”ct
$*%
[
;)QRR_
ˆ“
!
†ùt
$!*%
[
;)Q` N
ˆ“

Ð
ëN•$ôs[°±
!
¿^Ä̒[‰›æŽ]
|Ô[EG
!
ƒüN•s[°±
!
“”ct
$*%
y
èŠ(u¡[v_È
;)QX_Q =n.S.
X
O(
n
ˆ
“
!
à½t€ã

-‰›Eäã
T
-½tˆ“
;)Q
`Y
C†ùt
$!*%
[
T
-½tˆ“î|j³„¢
-\Y\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
[Q6
!
*€TÒâ[
3T>
‰›
!
äã
;)Q\M
ˆ“

f
Q!
“”ct
$>%
цùt
$7%
[Q‰›9À
tœâÑ-cùtâãÌt[
\Ñ
`[‘‰äªÒâ[‰›±y
!
±y[½tè
;)QR_N
L
R_Y
‡
>7
-½tˆ“
!
-cùtâ
ãÌtœy誱y[
T
-‰›½t
!RX
I)_[
$ôsæC=ªyÿ^ÄÌ[‰›äã|Ô[°±

$
Ž
%
R (!
³Ï
!
®v
!
ã¢Æ
!
‡
:
BCADO’[·[
38<.8C
z
fQ6…©
9(:
ÇÌ6¥¦
! XMMY! XY$`%, RXYR:
X (!
r­ÇÒ
:

1(:XMML, R_R:
Q (!
ª²
:
O’^_
#

#
ÜÛG[·ƒ„–´
9(:
rÚÇ
!
R``\! R`$_%, Q`:
_ (!
š
!
³œ£
!
Âïã
!
‡
:.8C<=1
)
©6l…O’?IJ
[^_Ú6
9(:
rÚÇ
! XMMY! XN$RM%, R_NN:
L (!d#$)*C!+4 C!+$/1 1!(2$&:#$%$G2(%a$2/) /66&$E/)/50)
2#((K2%$G2/61/V#/%$6&$E(0G()0>2:PB#*#G#%/I$2/*%$V#BG/4V&(5 F2# 5/5(<$%$B5(2(G2/%$)5 (&(G2%/0<
V%$B/)a$2/) I$000V(G2%/I(2%B9(:98#$%I$G(427/I(5
>)$&! XMM\! __$L%, RMR`:
Y (!
〛
!
ì2b
!
ÐØ
!
‡
:
O’ãÌt1¶N[Q6
9(:
6^_
! XMMY!Q_$X%, XML:
\ (!
³ 7
!
œ§ì
!
£N
!
‡
:
~NíOù“
1/V#/%$$&/V(G4<
%/5(0
ãÌtÚ6G6ˆƒ„
9(:
~Ní£__4
! R``_!
XL$Y%, YYR:
N (!1#*(%4 O!.%/2$W$O!.$*)F$9!(2$&:A#($&W$&/5 G/)0224<
()20/6N9:+.,%# $)5 2#(02(%(/G#(IG$&$00*)I()2/6
2F/0/I(%G0/V#/%5)(?XN$X%, L_Y:
` (!
Âí
!
`l^
:
Où“¢“rãÌt[6ˆG
&(#I$)))(
[
01/Ô
9(:
r­rÇ¥¦
! XMMY! QR$\%,LL\:
RM(!
Âí
!
ñt4
!
;Žî
:
O’¥rãÌtØI[^_Ú6
9(:
r’Ç
! XMMR! QX$_%, X`Q:
RR(!1$2/D! A$W$I$204 1! =4%$W/0#;:;0/&$2/) /6$)(F$&W$&/5
$<%<.<$G(2B&P$V26/&)($)5 2#($P0/&42(02(%(/G#(IG$&%(&$2/)<
0#V0/6&4V)($&W$&/50) 4:<+;.>%:%,<%9(:9?$28%/5!
R`N`! LX$L%, RMQX:
RX(!d#$)*cJ! d#$)*8! #()*cc:12%4G24%$&G#$%$G2(%a$2/) /6
0/V%()B&$2(5 6&$E/)/506%/ID40#() PB(&(G2%/0V%$B/)a$2/)
I4&202$*(2$)5(I I$000V(G2%/I(2%B9(:9=$001V(G2%/I!
XMMN! _Q$RM%, R_XR:
RQ(!
ñ
!
žÑ
!

!
‡
:
rÇO’‚&¨´ªÚ6[ƒ„
9(:
Ç__4
! XMMN! _Q$N%, NQQ:
R_(!=$%/@! C&5/I$%>! >G$G/T:L0/&$2(5 6%/I2#(F//5 /61G#a/&/P4IV$%$#BP$$U(&:% 1:J:
7&$W(9(:e4IG$?/E$! XMMN! QR$Y%, RQ_`:
RL(!b4 C9! =B$0(A! ,()/>! (2$&:1245(0/) 2#(G/)0224()20/6
A.>:.+# &=#-<<,>2:;U9(:c$W4*$W4 d$00#! R`NL! RML
$RR%, RMQ_:
RY(!C4 -.!eCb!8()*c7!(2$&:3$V5 0(V$%$2/) $)5 5()2<
6G$2/) /6L_ I$H/%G/)0224()20) 74B$)*.4$)F4 5(G/G2/) PB
4&2%$<6$02.8C0B02(IG/4V&(5 F2# T>T#%/I$2/*%! XMM`! XQ$N%, NXN:
R\(!
ñN
!
m±
!
ª 
!
‡
:
G¨´Z6G1ÿ[
-1;<;A[
Q±yG+Ñ
9(:
¡‡_Ç^__4
! XMM\! XN $RX%,
XXN_:
RN(!1#.! d#$/.:1/6&$E/)(0$)5 0/6&$E/)(*&BG/05(0$0$)25$<
P(2G0, 9$V$)! RRRRY_N\8(fR```ã¡
!
E)ê
!
µ8ã
!
‡
:
öävŸœ^_Ú6ƒ„
9(:
r
ÚÇ
! XMM`! QR$X%, XY`:
XM(!1%I$))$%$B$)$@! 3$/?U1:1B)2#(00/6Q<$&WB&6&$E/)(0PB
I/56(5 7$W(%#(I! R`NY! Y$RX%, Y`Y:
-NY\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR
=0.I1D/CABIKLE/G/LDAG0[/D0BCBMDZB DFNAKBM./WBG/LD0SA
LB.NBCACDK0CXIKEACOF E0UENAGMBG./CLA10]I0HLEGB./DBUG/NEF
LBIN1AHDB .I1D0SKD/UA./KKKNALDGB.ADGF
d.>Oe)^)! d.>?@c46()*! J>?+$/#4
!
$K<>#+!;<,!.&*:%,<6OKDG/LD(!;) 2#00245B!$#*# V(%6/%I$)G(&^45 G#%/I$2/*%$V#BG/4V&(5 F2# I4&2<02$*(I$000V(G2%/I(2%BI(2#/5 F$05(<
E(&/V(5 6/%0I4&2$)(/40G#$%$G2(%a$2/) /6$&W$&/50$)5 6&$E/)/50! 2#(I$) $G2E(G/IV/)()20! ) D40#() F2# 5E(%0(V#B0G$&$)5
G#(IG$&V%/V(%2(0:J/%2B<2F/I$H/%G/)0224()20!)G&45)*0K2(() D40#() $&W$&/50$)5 2F()2B<0KD40#() 6&$E/)/50F(%(2()2$2E(&B
5()26(5:>552/)$&B! 40(64&$)5 G#$%$G2(%02G6%$*I()2$2/) V$2#F$B0/62F/2BV(0/6D40#() $&W$&/50! )$I(&BGB20)(S2BV($)5
0V$%2()(<2BV(! ) V/02E(/)0I/5(F(%(V%/V/0(5 $)5 04II$%a(5! F#G# F/4&5 &$B$6/4)5$2/) 6/%2#(%$V5 5()26G$2/) /62#(
$G2E()*%(5()20) 2%$52/)$&#)(0(I(5G)(D40#():
XAF ZBGHK(!D40#()& $&W$&/50& 6&$E/)/50& #*# V(%6/%I$)G(&^45 G#%/I$2/*%$V#BG/4V&(5 F2# I4&2<02$*(I$000V(G2%/I<
(2%B& 12%4G24%$&5()26G$2/)
HB0,!+ %`#)RLWL..#+!!+#&
$
‚ƒ$Q
!
¦Z§
%
¨©ª«žŸ
[t¡œ
7

8!
uø[t¡œ
(@.,%#;9+<,%3(*(&(23$55(
[xìO’

7
ÑM
8!
|l’
7
¢M
8!
©þœ
#
©nœ
#
©£œ
#
­©œ
#
Aoœ
7
ÈÉÌ
8!
‘÷㒣
!
‰¡m
QM GI
ìí‰Yf
!
¤ãu}$ì
&
‰g6¤
!
?}Lxã¥}
!
–sØè(“¯}L
v}[ù[–

c]œ¾]Ë
!
‰¬Øc–zm
\ mRM GI!
ct»„`~
!
zm
\:L GI!
/
` GI!Q
ʖíK‰
!
~߉t
¦}~
!
/B
R mR:L II!
–-u

œH㉭
!
ÖB
Q GI&
itBê
`!
z¤~Lœ¬íz¤~
!
¨}
!
gxã}
!
iœh‡z
L¾z
&
œhBê
RM!
z¤~
!
¨}
!
z
R:_ mX GI!
/
M:L mR GI!
˜¤~Lœ¬í˜¤~
&
E’‘(
!
zB
Q II!
á}‘(
!
“
qè%u
!
yfœÚ
!
چ8
!
i~

YŒœ¬íi~
!
zB
_ II!
èf%u
!
Œ§VƒÚ¨í

œ—
Q m_
´
&
Œ—
_ mL
´

7
ã
8!
ã•)©
XMM mR QMM I
[©ä
#
’ªGs¬„Õ«Ö

7

8!
þü
&
f?
#
§£
#
å€=
$
¥þQ+
%#
op

£Q+[¿ST

7
ÒÜ
8!
R̉ìj$O’
!
NMkU
!
ý‚
!
ý6

7
^_Ú6
8!
O’\’=s
#
¬£ôw
#
¬£ô•w
#
¨ôw
#
š`Gw‡‘¢òáÿ
R(
7
ǤE“
8!
£>ÝÛ*ÍBSÊÌ[áÄoÿ•J¤—
!
“•¤SÊ̈ÿáÄGéígáÙÆ.èòáw[E“

8wè…([­WE“
!
i‰Ü8«[n€Ê

7
èài
8!
èO
!
¨
!
—
!
è8G

èòá®X[ài

7
‚“©
8!
“•á®
#
áĝ_”
#
¯°
X(

7
“·
8!
¸KV
XL I*!R
§
R mQ
5
&
L_ÝLtÝ
!X:L *R
§
X
5

£>G„£
!
“9×±ú²

7
?
8!
£+ZÕÉÌlè
R
¢
,
r [t¡œ
(6+#;.# J%$)G#:!
‰-uL­Øèfu
!
‰ãc
_!

&
υ
X:L m_
GI!
it
_ mL!
úã}
!
9¬~L9³~
!
ƒœhf
&
YŒ-u

ã•)©
QMM m` MM I
[†á©ä_

6à•þü
&
f?
#
§
£
#
å€=
$
¥þQ+
%
£Q+[°é
#
m^
#
Æ!‡ST

ªÇZ[t¡œ

-`Y\-
{
QY
ï{
Y
—
XMRR
÷
Q
´
!!!!!! ! ! ! ! ! !!!! ! ! ! !
U/&fQY! ;004(!Y
=$%G#! XMRR