免费文献传递   相关文献

Effects of mangiferin on cytokines in rats with chronic bronchitis and expression of macrophage COX-2 in mice

芒果苷对慢性支气管炎大鼠炎症因子及小鼠巨噬细胞环氧化酶-2表达的影响



全 文 :¦•¡A¢›Ý§¨©|}©ªYNG6}«¬
ab*­\®
¼k[TU

P
#
¸¹è
P
!
#

P
#
þnj
W
!Ph
ãQ8H¯J
#
ãQ }à
LOMMMP% Wh
ãQ23©¯J
#
ãQ 2
LO[MMM
$
‚;
%!

&
B†¦•¡[m©E›ÆÜ

•–
.
±™I
$C81% n
­çLM”õ-|}¢›Ý§¨©câ
!
%濾~
\s
$7>CJ%
ÑQór[ ­\í\®
$1TR%
כ
#
/üÌ
$=R>%#
|­\›
$?T%

!
¶ÙEr‚‡ƒÐYN
$A?J<

%#
t
ab}—
N$;C
&
¡K%qĮ¦$3A<83%
W%
C81
LM
3>cWX^h[
6}«¬ab*­\®

[¼k

—˜
.
~¦•¡#
#
r
#
êÛ·
$^MM!WMM!PMM I*/V*
QP
%
ŒÍ¢›Ý§¨©|}
7>CJ
ÑQór[
1TR
כ
#?T
Z
·.u3#
! =R>
Z·.uðê
&
¶ÙEr
A?J<

!;CZ·.uðê
WMM!PMM!LM
!
I/&/C
QP
¦•¡Œ*u¡ðê
C81
L
Mª[
3>cWX^h[ T+
¼k

—™
.
¦•¡m©ÆÜ*gi3#
1TR
כ
!?T

!
ðê
=R>

!
ªA
A?J<

!
;C
[¼k
!
»«©ª¦\è‰

$
ƒ„…
%!
¦•¡
&
¢›Ý§¨©
&
©ªYN
&
*­\®
$
8†$f
%!WMPMM^OMMPW
$
‡ˆEq
%!
­æléö]stuv
$OM^XMPL[%
$
‰€>Š
%!
!
îæ˜
!
Ž/
!
z{ãMä
!
‚&±×rÇs©¥,
irÇÇ郄
!-$
>Šš›
%!
þí
!
Ž/
!
±{
!-!!
¦•¡
$I$)*6(%)%
«Mí!ž
P(
!
N񋪔
É̦•˜rµ#[\]Ú6

¦•¡wè.u[

#

#
op
#
@GE›
!
m©E›ÆÜi¤Ü*
­\®[כè‰
W
¤7D›±™I
$C81%
a
­çLM¢›Ý§¨|}câG±™ILM
3>cWX^h[
6}«¬ab*­\®
sY
¼k§¨
!
î|űÆþ©ª¦\j‰YNB†¦
•¡[m©ÆÜ

!
ÁÂ
! !^
ÊÌiab
ó£ü›
1R
|}
!
-·ýRxfS§¨Ê
Ìrßµo
!
‹*Æf
1+D$
ð
%3>cWX^h[
ab
$
6}[櫬aba
%
ølr­
ö]è_&abƒ„²

! #^
ÇÌiçÛ
¦•¡êT({G_
!
-6)r…]èmu¼
ÇéÉ´rßµo
!
Ãf
WMMXMXMN!
=
_Wm
_
&
¡›Çi@Q‰‡Ç
!
-wÀÐñÜÇãtè#–
$ãä
!
Ãf
MNMXPN&
±™I
$C81%
êÙ­
1*I$
–
$6ú
!
Ãf
WMMNMN
 ­\Ìò\®
$ 1TR%#
/
üÌ
$=R>%#
|­\›
$?T%
çÛ¨Œ-ýùõÚ
ãÌNôƒ„²o!
à f 6 Œ ê
MNM[PX!
MNM[WMP!MNMXW^&
|}t}—
N$;CçÛ¨êøù
ˆ|ã̅]÷Ñè#–$äF
!
Ãf
MNM_P^N&
|
}‚‡ƒÐYN
$A?J<

%
çÛ¨êøùˆ|ã̅
]÷Ñè#–$äF
!
Ãf
MNM_WWP&
ós
3A<83
çÛ¨êýùósãÌö÷ïè#–$äF
!
Ã
f
MNM[PL
#
…”
# !^
¦•¡A¢›Ý§¨©|}©ªYN[TU
# !^ !^
¢›Ý§¨©|}câjÜG6ÙÛÇ
!
D›§¨?б™I·Ä­çLM”ÜEcâ
^!
ü›
1R
|}
[M
â
!
þi
WWM gW^M *!
¬Æ6ê»
Ù
#
‘¨ÑÙ
#
¨ÑÙ

¨Ñٝ§¨{
P!P^
8
!
PMm
VcIÈ(|}
!
DhEq
!
64ôT§¨
!
†
§¨~?´
MhPm C81 WMM
!
C!
‘¨ÑÙYã¥
æ¸ôF
C81
±§¨{
W
8—˜
!
ä»Ù|}
g®[
XM
â|}6£
O
¯Ü[­`
$PMM GIi
XM GIi^ M GI%!
7­`^Ð
WM
â|}
!
7­`
7875õ­
$
.
W^
Ý
!
78
_M I)!
Ðõ­
^M
5%
»Ù|}Y³Ö¥
!
>£,­*3×=

6ÙGÛÇ
.
§¨{
WN
8
!
¨ÑÙ¬Æ6êcâÙ
#
¡›A“Ù
$
Q‰‡Ç
W I*/V*
QP
%#
¦•¡#
#
r
#
êÛ·Ù
$^MM!WMM!PMM I*/V*
QP
%!

PM
â
!
¦
/N^OP/
{
OX
ï{
PM
•
WMPP
÷
L
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! ;004(!PM
=$B! WMPP
•¡¿Ù’j\Û·~ÛÇ
!
»Ù
#
‘¨ÑGc
âÙÛ܇þUã¥æ¸
!
¯ÆÛÇ
PW 5
# !^ #^
|Ÿ®´[JK
!
_%|}[ÐÃ(v
!
×
Êëì
!
PI†
!
îv¸
#
þiD\‡®´

# !^ $^7>CJ
ab_(Gtab6¨
!
|}ÛÇ
{
PW
8
!PMm
VcIÈ(
!
DhEq
!
64ôT§¨
¾îɧ¨^¨
!
—pQ¨öÛr^‚ݧ¨
!
›
?´à­#,3ã¥æ¸
PM IC!
6
O
5îÉéÝ
§¨¶Ñ~!
ÈH~\s
!
ÈHsê
[Mm gNMm!
^ j!P LMM %/I)
QP

PM I)!
&_ós
$ QNM j
z0AŒ
%
÷4Étab_(G6¨

# !^ %^7>CJ
s
#
Q‚r
1TR
כ
!=R>!?T

[%Ô
!
|}éݧ¨¶Ñ~\¾
!
ªæ²³#Q
!
O MMM %/I)
QP

PM I)!
#_ó
!
2Œ“çÛ
¨h.W%
7>CJ#
Qór
1TR
כG
=R>!
?T


# !^ &^
¶ÙEr
A?J<

!;CZ·%Ô
!
|}éÝ
§¨¶Ñ~\¾
!
#^¶r˜—4¶ü
PZO
Öøë
T/ù#Á
!
]
^ j
ã¥æ¸rú\Õì
!
T]G7
¾Pi
Mh^ *!
aг€[ã¥æ¸±
^ IC!
›ab
G†ÆÜÚ
PMm
[¶ÙE‘‚
X MMM %/I)
QP
4
ß
L I)!
#_ó

2Œ“j\[çÛ¨%Ôª


# #^
¦•¡A±™ILM[
3>cWX^h[
ab*­

¼k[TU
# #^ !^
abõ=
X(
!3>cWX^h[
ab]
O[ j!Lm
T
W
ïqª
!
›Z
PMm
6ÏQó
#PMM ,/IC
QP

V—GÂV—[
R=-=
õ=sr!ôõ=

›Š
¤,Qó[
R=-=
õ=sV֝A(ãx•[a
b† 
W^
 õ=«r
!
áêctA“Ù
$MhMLm
R=1T%#C81
câÙ
#
¡›A“Q‰‡ÇÙ
$W
!
I/&
/C
QP
%!
¦•¡#
#
r
#
êÖ¥Ù
$WMM!PMM!LM
!
I/&
/C
QP
%
# #^ #^
ÇÌÖ¥
!
aÐY<ê
P I*/C
QP
[
C81
$
ctÙä®
%!

O[ j!LmT
W
õ=0rõ=
_ #
¾
!
Ö]¿Ùa_j\[ÇÌ
!
é¾8Æ]
O[ j!
LmT
W
õ=0õ=
PW #
¾#K

# #^ $^3A<83
W%
T+
¼k
!
¦)
A%<
b/&
çÛ¨h.Ƶ#ab5
3?>!
’|ŔçÛ
¨Å¢îÉ
3A<83 T+_ʓÌ
LfA@@AA@>A@>A@ª Ê “ Ì
Lf<@>>A<
>@>AAAA@@A>A@äÌxê
WLW dU!
#
<$G2)
_ʓÌ
Lf<>>@@>>@@>@>>@>A@><
Of!
ª Ê “ Ì
Lf<>@@@A>>A@@A@@A@@<
>@>äÌxê
LN[ dU!
ŒêøùƒzJ¤
ãÌ÷Ñè#kl–$ÄÚ
83
¦\ïqê
._^
j
³D›
L I)&_^ j

OM 0&LX j
Ê°
^L 0&[W
j

P I)&

OW
Î*
&[W j

PM I)
# #^ %^
{±I²ñ.…
!
Xº¾äÌaÐ
PZX
þ
UxQ¯_Gø[sC‘
!
#
WM
!
C

Pm
{±I
²ñ_îÉ.…
!PMM S
²M.…
PhL # R/G@(&
PMMM
²ñÚûFãJKG “

Z7îÉGI
U6_6‹
!

T+äÌi~“ #
<$G2)
83
äÌ[GIU6_gHEê
T+
[jAZ·_

# $^
()Ö¥
²&()›
Kp9
¼½
!

1811
ã.¸qî
Éã.6‹
!
ٚD#
!
W¨…”

$

$ !^
¦•¡A¢›Ý§¨©|}©ªYN[TU
$ !^ !^
¦•¡A¢›Ý§¨©|}OWëì[T
U
!
Èc¾
!
câÙ|}KRüý
!
×Ê»e
!
P
\GǪI†
!
eè;ƒ

¦•¡Ù[®´.u
¾Ì

$ !^ #^
¦•¡A¢›Ý§¨©|}
7>CJ
rta
b[ab]¾D[TU
!
i»ÙjH
!
câÙ[
tab5·
#
r›ÖabG“~abŒu¡3#
!
«
¬abðê

ÛÇÙYHcâٌè.u¾Ì

¼
.¦•¡*u¡¾Ì¢›Ý§¨©|}
7>CJ
rt
ab[ab]ë´fðêݧ¨©ª
$
¼
P%
$ !^ $^
¦•¡A¢›Ý§¨©|}Qór
1TR
×
›
!=R>!?T
Z·[TU
!
câÙ[
1TR
כ
#?T
Z·jA»Ù.uðê
!=R>
Z·YjA»
Ù.u3#

¦•¡#
#
r
#
êÛ·ÙYjAc
âÙè.u¾Ì
!
¼.¦•¡#
#
r
#
êÛ·ÙBg
¤Ü¢›Ý§¨©²“³[|}Qór
1TR
כ
#
?T
Z·[ðêG
=R>
Z·[3#
!
‡E›Q
¬Û·[ºafºQ
$
¼
W%
h.¦•¡*µ#
¢›Ý§¨©|}óäl-s[gN
!
±f»«|
}±Y¡­\hi

$ !^ %^
¦•¡A¢›Ý§¨©|}
7>CJ
r
1TR
כ
!=R>!?T
Z·[TU
!
câÙr
1TR
כ
!
?T
[Z·jA»Ù.uðê
!=R>
[Z·Y
jA»Ù.u3#

¦•¡#
#
r
#
ê۷ُ
/_^OP/
{
OX
ï{
PM
•
WMPP
÷
L
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! ;004(!PM
=$B! WMPP
!!
¼
P!
¦•¡A¢›Ý§¨|}
7>CJ
rtab[ab]¾D[TU
$

Kp9!(YPM%
ٌ
Û·
ZI*/V*
QP
tab5·
ZiPM
_
/C
QP
ab6¨
Zm
«¬ab r›Öab “~ab
»
!! Q M:XW pM:MN NO:OL pL:WX X:^L pM:NL PP:^L pL:PW
‘¨Ñ
! Q M:LN pM:PW NP:^X p[:W^ N:^[ pM:X_ PM:XL pW:WP

!! Q
^:WL pP:M_
W%
^X:XP pL:XW
W%
W[:^_ p^ :P^
W%
WX:^^ pO:L^
W%
Q‰‡Ç
W
P:W^ pM:NP
P%
[L:X_ pN:^^
P%
_:LX pM:NW
PX:PL pW:X_
P%
¦•¡
! PMM
W:O^ pM:LX
P%
LX:OX pL:XL
P%
WW:^L pW:X_
P%
WW:OX pW:[P
P%
WMM
P:NP pM:_O
P%
XX:OL pP:L^
P%
P_:WO pP:XP
P%
PL:WW pP:N[
P%
^MM
P:^^ pM:^_
P%
[O:^[ pW:MP
P%
PL:WW pP:WP
P%
PW:^L pP:W^
P%
!!
?
.
icâÙHI
P%
?qMhML&
i»ÙHI
W%
?qMhML$
¼
W g^
Z
%
¼
W!
¦•¡A¢›Ý§¨|}Qór
1TR!=R>
Ñ
?T
[TU
$

Kp9!(YPM%
ٌ
Û·
ZI*/V*
QP
1TRZ,/IC
QP
=R>Z
!
I/&/C
QP
?TZ
!
I/&/C
QP
»
!! Q WMP:MO pX:[_ ^:WO pM:[W PO:_L pW:^^
‘¨Ñ
! Q WMM:^P pN:M^ ^:WL pM:L^ P^:LM pW:_L

!! Q
PXW:O_ pN:__
W%
X:X^ pM:[O
W%
[:N_ pP:PL
W%
Q‰‡Ç
W
P_X:^P p[:M^
P%
^:_^ pM:^M
P%
PW:PN pW:PP
P%
¦•¡
! PMM
P[O:PO pPP:_[
P%
L:NN pM:_[
P%
_:_P pP:W^
P%
WMM
PN[:^_ pL:^M
P%
L:W_ pM:[W
P%
PM:NO pP:P^
P%
^MM
P_L:PL pL:LP
P%
^:NL pM:X_
P%
PW:^O pP:ON
P%
G¡›A“Ùr
!1TR
כ
!?T
[Z·jAcâ
.u3#
!=R>
[Z·YjAcâÙ.uðê
!
h.¦•¡#
#
r
#
êÛ·ÙBg¤Ü¢›Ý§¨©
²“³[|}
7>CJ
r
1TR
כ
#?T
Z·[ðê
G
=R>
Z·[3#
!
‡E›Q¬Û·[ºa
fºQ
$
¼
O%
h.¦•¡*µ#¢›Ý§¨©
|}óäl-s[gN
!
±f»«|}±Y¡­hi

¼
O!
¦•¡A¢›Ý§¨|}
7>CJ
r
1TR!=R>
Ñ
?T
[TU
$

Kp9!(YPM%
ٌ
Û·
ZI*/V*
QP
1TRZ,/IC
QP
=R>Z
!
I/&/C
QP
?TZ
!
I/&/C
QP
»
!! Q WW:^ pP:[W M:[^ pM:MX P:MW pM:PO
‘¨Ñ
! Q WW:[L pW:WW M:[W pM:MN P:MO pM:PL

!! Q N:M^
pP:MP
W%
W:WM pM:WL
W%
M:O[ pM:M_
W%
Q‰‡Ç
W P[:O^
pW:PW
P%
P:P_ pM:OM
P%
P:MW pM:P[
P%
¦•¡
! PMM PM:ML
pP:W_
P%
P:[M pM:WP
P%
M:^N pM:PP
P%
WMM PO:^N
pP:_L
P%
P:LL pM:P_
P%
M:L[ pM:PM
P%
^MM PL:W^
pP:L^
P%
P:P_ pM:OM
P%
M:[_ pM:PP
P%
$ !^ &^
¦•¡A¢›Ý§¨|}¶ÙEr
A?J<

!;C<
N
[TU
!
i»ÙHI
!
¢›Ý§¨©|}¶ÙEr
A?J<

!;CZ·u¡3#
!
Ëãä¾
!
¦•¡#
#
r
#
ê
Û·Ùr
A?J<

!;CZ·u¡ðê
$
¼
^%
$ #^
¦•¡A±™ILM[
3>cWX^h[
ab*­

¼k[
3A<83

ctÙ[
T+
[¼k5ê
!
f
C81
câÙr
T+
[¼kYjÎ#
!
¼.
T+âè]
C81
[¶£ªþäã#¼k


Q‰‡Ç
$W
!
I/&/C
QP
%
¾
!T+[¼kjÎê
!
¼.Q‰‡ÇA
C81
LM[
T+¼kèIQ[
¤ÜE›


LM!PMM!WMM
!
I/&/C
QP
[¦•¡
¾
!T+
[¼kŒ.uªð
!
¼.¦•¡A
C81
LM[
T+¼kèu¡[¤ÜE›
!
‡¬C
Û·[ºa
!
¦•¡A
C81
LM[
T+¼k[¤
ÜE›ºQ
$
d
P%
%
†,
­l-si©ªãèC3E‰F
[(
!
¢›Ý
/MLOP/
{
OX
ï{
PM
•
WMPP
÷
L
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! ;004(!PM
=$B! WMPP
!!
¼
^!
¦•¡A¢›Ý§¨|}¶ÙEr
A?J<

!;C[TU
$

Kp9!(YPM%
ٌ
Û·
ZI*/V*
QP
A?J<

Z)*/V*
QP
;CZ)*/V*
QP
»
!! Q O^:NL pX:N_ W[:W[ pO:N_
‘¨Ñ
! Q OL:WM pX:P^ W_:O_ p^ :LW

!! Q
X^:P_ pX:W^
W%
LX:M
pX:WL
W%
Q‰‡Ç
W
ON:__ pX:_[
P%
OW:NX
p^ :[_
P%
¦•¡
! PMM
LW:LP p[:W_
P%
LM:PN
p^ :ML
P%
WMM
^X:P_ p[:PX
P%
^X:P_
p^ :^[
P%
^MM
^W:WW p[:N_
P%
O_:M_
pL:LW
P%
=h=$V(%&Ph
ctÙ
&WhP I*/C
QP
C81&OhP I*/C
QP
C81 n
¦
•¡
WMM
!
I/&/C
QP
&^hP I*/C
QP
C81 n
¦•¡
PMM
!
I/&/
C
QP
&LhP I*/C
QP
C81 n
¦•¡
LM
!
I/&/C
QP
&XhP I*/C
QP
C81 n
Q‰‡Ç
W
!
I/&/C
QP

d
P!
¦•¡A±™ILM[
3>cWX^h[
ab
*­\®
¼k[TU
§¨©|}[
1TR
כªð
!=R>
Z·ºa
!
h.
¢Ý|}äã|·l-s
!
±Y¡­\¦\ºQ

?T
NãÌþ~×X[™Þgabnf6N
N(
!
Z
7`N| ©›YN
!
i™ ÿG›tu[ãè
C3E‰F

¤§¨0•¼.
!
¦•¡*.uµ#
¢›Ý§¨©|}QóG
7>CJ
r
1TR
כ
!?T

!
ðê
=R>

!
µ½¦•¡gô¤Ü­l-
sÑ¡­\¦!
»«¢›Ý§¨©ª§‘hi
!
±
f»«©ª¦
‚‡ƒÐYNN| ab¦\YN
_(
!
*L
|FJ©ª¾D
!
“³§‘hi
;CN| i&
[©ª}Y
!
稃„¼.
PM(
!;CN¢›Ý§¨
7“³r›Öab2\‚&2\YN
;C*ÍQ
¨mÿ›ºa
!
¾Dr›Öabi~Œab[)
!
>ѪÆ2\YNG“r›ÖabѪƩªa
!!!
bq®9§‘
!
­^¿ ×›®Ñ©ª}Y
!
}M§
‘©ª[ãÑï

¤ƒ„u½
!
¢›Ý§¨©
r|}¶ÙEr[
A?J<
G
;CZ·Œu¡3#
!
fË¡¦•¡[ãäE›¾
!
¶ÙEr[
A?J<

!
;CZ·ŒèYZô[ðê
!
‡¦•¡A¢Ý“
³[
A?J<

!;CZ·¤ÜE›SÛ·j‰

h.
¦•¡gm¡ðê¢Ý|}þ~
A?J<

!;C
@
!
»«ªA§‘hi;¤Ü©ª[ïGã

tƒ”
#
hJ¾—Ni©ª¦\[i&}
Y

¦•¡*m¡¤ÜC㖔@[*­\®
å¼f³9m©E›
!
fA±­\®å¼ôÚP
èTU
O(

]*­\®å¼r
T+NLM®
!
]©ªabr#¼k
!
îf“³©ªØI
8@-
W
‡äÌ|·ºa
!
™î©ª¦\ÑÙEKh

¤
ç¨0•¼.
!
¦•¡*m¡¤Ü
C81
LM[
3>cWX^h[
6}«¬abr
T+[¼k
!
³9
m©[E›

$
‹ŒŽ
%
P (!
ôU_
h
rÇ\]
=(h
_&
.
_&ö÷KÂn
!P__N.PXNh
W (!
îæ˜
!
!üù
!
ëE7
!
‡
h
¦•¡A= YZ©ªcâh
J¾—
-W
Z·[TU
9(h
rÎr…Ç]§
!WMMN!WX$PM%.
WMNLh
O (!
îæ˜
!
ö-¶
h
¦•¡AC㖔@ôƒäÌ[TU
9(h
r­ÏZ…Ç£¤
!WMMN$PM%.LXh
^ (!
¯
!
?{‡
!
×Z+
h
§¨~?б™I”õ-|}¢›
ݧ¨©câ
9(h
rÎ0*ÑÿG£¤
!P___!PWW.O[Ph
L (!
s|@
!
?{‡
!
…õŽ
!
‡
h
¢›R‰›¶tu|}câ[
õ-GÇÌÕ³[TU
9(h
rÎ~ö£¤
!WMMP!NP $N%.
LMXh
X (!
×ã
!
ò:8
!
$Ùþe
h
ÈCç—A±™ILM
3>cWX^h[
ab
T+®×›
#I3?>
GÝt¼k[TU
9(h
Ç]]
1
!WMML!^M$L%.^MXh
[ (!
ÿù‰
!
ÏøÂ
h
=œó¶I‚A­ç“³[¢›Ý§¨©
|}©ªabG
1TR!=R>!?T
[TU
9(h
rÇÁ
!WMMX!
W_$O%.W[_h
N (!8(%00/) =@!e(2(%02%/) T!>*(%)40S!(2$&h1)*&(d%($2# )%<
2%G/K5(I($04%(I()20) $02#I$2GU$2()20$)5 0I/V(%09(h
C$)G(2!WMM^!LO$^%.L^[h
_ (!
$ŠÖ
h
ݧ¨©i#G[abYND9(h
r΅]O
ö£¤
!WMM^!O$P%.[Ph
PM(!.&$2!7$B&(B5!12/GV&(B%$hA#()2(%(&$2/)0#U /60U424I)<
6&$II$2/%BI$%V(%0) U$2()20F2# G#%/)Gd%/)G#209(h>I9
3(0U%%2$%(=(5 !P___!PXM.N_Oh
/PLOP/
{
OX
ï{
PM
•
WMPP
÷
L
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! ;004(!PM
=$B! WMPP
,LLATDKBL./CU0LAG0CBCTFDBY0CAK0CG/DKW0DETEGBC0TNGBCTE0D0K
/CHAPMGAKK0BCBL./TGBME/UA28[-W 0C.0TA
c>?@ `)
P
! R-?@9$*$)*
P
!
! a>?@D(
P
! +,C$)G#()*
W
$Ph$/7(3K@:7+!)(7.2,(191#1+67.E(F1:9!-! ;7(((3 LOMMMP! 2,(7&
WhO/.( ;):07.E(F1:9!-! O/.( LO[MMM! 2,(7%
6NKDG/TD(8N]ATD0RA. A/(KU&/%(2#(I(G#$)0I/6$)2<)6&$II$2/%B(6(G2/6I$)*6(%):>ADEBH. A#(I/5(&/6G#%/)G
d%/)G#20) %$2F$0(02$d&0#(5 dBC81 n0I/V(:A#($G2E2B/61TR! G/)2()2/6=R>$)5 ?T) 7>CJ$)5 0(%4I! G/)2()2/6A?J<

$)5 ;CcWX^:[ I$G%/U#$*(T+)54G(5 dBC81 ) IG(F$05(2(G2(5 dB3A<
83::AKI1D. A#($G2E2B/61TR! 2#(G/)2()2/6?T) 7>CJ$)5 0(%4I) %$2F2# G#%/)Gd%/)G#20F(%(0*)6G$)2&B#*#(%F2#
#*#! I(54I$)5 &/F<5/0(/6.3 I$)*6(%) $^MM!WMM!PMM I*/V*
QP
% ! F#&(2#(G/)2()2/6=R>! $)5 2#(G/)2()2/6A?J<

$)5
;CcWX^:[ I$G%/U#$*(T+)54G(5 dBC81 F$00*)6G$)2&B%(54G(5 dB
I$)*6(%) F2# WMM!PMM! LM
!
I/&/C
QP
:2BCT1IK0BC. A#($)2<)6&$II$2/%BI(G#$)0I/6I$)*6(%) 02/%(&(E()6&$II$2/) dB
%$0)*2#($G2E2B/61TR$)5 G/)2()2/6?T$)5 %(54G)*2#(G/)2()2/6=R>$)5 2#((KU%(00/) /6A?J<

! ;C:
aAF WBGHK(!I$)*6(%)& G#%/)Gd%/)G#20& GB2/V)(0& T+HB0.!+b%#)QT]T..#+!!!+##
$
$Q
!
¿ÀÀ
%
œ
!!

ö]KÂn
WMPP
÷
O
²K-r­ÇFãÌÜFWÔ²v‰ Ž/‚W[
,
r­ÇÁÀ+M%
-
EF]­æv
FÇF—˜¨¥2[|NÝHÑO­¿R
#
lã(
#
û$SÇW²[UôáĪ
!
±
WMM^
÷—˜
!
H®ž¥ñÂÇÒ
!
ØáÀ
+
#
Q…À+‡|·™Â
!
ñ7
X
÷
!
îɐaí9
!
Wz8¤¿×
#
§›[rÇÁÀ+WC«þNwÆ

4ÆÐH%

^ [MM
ç ÇÁ
!
™G
LOM
ö
!
~Ò¯ÇÁM
#
öM
#
c(öM
#
¨Œ
$
ÊÌ
#
ÉÌJËÌ
%
ÈÊÉÌr7M
#
ÈÊÉÌc(
]M
#
ǛØIGKև

Wzy.
!
~§›
!
Nàþ
#
…èr…Çö÷NEF‘Ý[
#
¿×[ÇÁÀ+WC«þNwÆ

Î
θ
#
z’¸
#
ŠÎƈG…]«þˆèš

ÔR
W_N
8

./
.MPMQ%
.
øùSú(¶êøþ
PX

]KÂn
$PMM[P[%&
·F±
.
@Š2
&
#]ÿ‹ž?.²ødÆ[ÆM
#
Œ(
#
·F./
#
N&‡

/WLOP/
{
OX
ï{
PM
•
WMPP
÷
L
²
!!!!!! ! ! ! ! ! !!!! ! ! ! !
S/&hOX! ;004(!PM
=$B! WMPP