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期 刊 ：中国中药杂志 2008年 33卷 04期 页码：377.

关键词：两面针；总生物碱；大孔吸附树脂；纯化；

Keywords:Zanthoxylum nitidum, alkaloids, macroporous adsorption resin, purification,

摘 要 ：目的:研究大孔树脂分离和纯化两面针中总生物碱的工艺条件。方法:以总生物碱的吸附量和解吸率为考察指标,对8种不同类型的树脂进行评价。结果:XDA-5型大孔吸附树脂对两面针中总生物碱具有较好的分离能力。通过大孔树脂分离纯化后,终产品中总生物碱的纯度为33.25%,保留率达到90.15%。结论:采用本法分离纯化两面针中总生物碱是简单、可行的。

Abstract:Objective: To obtain the optimal conditions for separating the alkaloids from the extract of Radix of Zanthoxylum nitidum by selecting appropriate macroporous adsorption resins.Method:Eight types of macroporous adsorption were evaluated in separating efficiency with measuring the adsorption ratio and eluting ratio of Alkaloids as indexes. Result:The XDA-5 macroporous adsorption resin had the best separating efficiency.After enrichment and purification with it,the product purity and yield of alkaloids were up to 33.25 % and 90.15%,respectively.Conclusion:This method is simple,feasible and fit for industry production.

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