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作 者 ：张力,杨晓晖,2 孙震晓,曲毅

期 刊 ：中国中药杂志 2009年 34卷 13期 页码：1724.

关键词：何首乌；安全性评价；回顾性研究；风险控制；不合理用药；

Keywords:Polygonum multiflorum, safety evaluation, retrospective study, risk control, irrational use,

摘 要 ：目的：为了了解与何首乌有关不良事件相关不合理用药情况及影响因素，提高临床合理用药水平控制风险提供依据。方法：检索1978－2008年国内公开发表的有关何首乌相关不良事件个案病例报告信息，进行调查登记、数据整理、统计分析。结果：共获得文献26篇， 涉及不良事件38例，包括变态反应10例，肝损害24例，其他4例。结论：无论患者自用还是医师处方，何首乌不合理使用情况普遍存在，这是用药后出现不良事件的主要因素之一，提高临床合理用药水平是控制其风险的最重要途径。

Abstract:To provide a reference for rational clinical medication and review the irrational use and factors relating the adverse events of Polygonum multiflorum The literatures on P multiflorum published between 1978 and 2008 were reviewed and the reports on clinical use were analyzed A total of 26 literatures were retrieved 38 cases of adverse drug event were reported，10 cases of allergy， 24 cases of liver damage， and 4 cases presented with other adverse events Irrational use is common in both self medication and doctor prescription It is one of the main factors of adverse events Improving clinical rational use is the most important way to control its risk

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