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作 者 ：柴程芝,寇俊萍,朱丹妮,严永清,余伯阳

期 刊 ：中国中药杂志 2009年 34卷 20期 页码：2673.

关键词：中医诊疗模式；病证结合；动物模型；

Keywords:diagnosis and treatment mode of TCM, combination of disease and syndrome, animal model,

摘 要 ：构建病证结合动物模型要符合中医临床诊疗模式，应该遵循“方-证-病-效”相结合的研究思路。所谓“方”，是指临床疗效确切的经典复方。“证”是指方证，即复方的临床应用指征。“病”，是指现代医学疾病。“效”是指疗效。构建病证结合动物模型要选择临床疗效确切的经典复方并规范其临床应用指征，挖掘与复方主治证候相关现代医学疾病的关键病理环节选择恰当的造模方法，通过动物再现较直观、较明显的主要症状和体征，再以复方干预进行疗效验证。这种以临床疗效确切的经典复方为切入点，采用能够体现证候与疾病关联性的造模手段构建动物模型的思路不仅符合中医临床诊疗模式，还可以为病证结合动物模型的构建提供思路与方法学借鉴。

Abstract:Combination disease and syndrome to construct animal model must be accord with the diagnosis and treatment mode of tradition Chinese medicine (TCM). The construct ion method should abide by the mode of combination prescription， syndrome， disease and efficacy. Prescription refers to those classic and effective formula. Syndrome refers to the symptoms and signs of prescription. Disease refers to model medical disease .Efficacy refers to the results of treatment. Constructing animal model should choose the classical prescription and formulate the clinical signs and symptoms. According to the main pathological process of modern diseases related to the syndrome to mine the methods of constructing animal models to express the main signs and symptoms， at last to testify the efficacy through the corresponding prescription. This method of constructing animal model is not only accord to the mode of diagnosis and treatment of TCM， but also affords a certain example of constructing animal model of combination model disease and syndrome.

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