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作 者 ：胡国华,林鸣,畅亦杰

期 刊 ：中国中药杂志 2010年 35卷 24期 页码：3386.

关键词：哮喘；儿童；白细胞介素-4(IL-4)；白细胞介素-13(IL-13)；γ-干扰素(IFN-γ)；中西医结合；孟鲁司特；平喘汤；

Keywords:asthma, children, IL-4, IL-13, IFN-γ, integrated traditional Chinese and western medicine, Montelukast Sodium, Pingchuan decoction doi:10.4268/cjcmm20102434,

摘 要 ：目的: 探讨中西医结合对哮喘儿童Th1/Th2细胞因子影响的研究。 方法 :随机分为对照组和治疗组,对照组用孟用鲁司特片2~5岁4 mg,6~14岁5 mg,每晚1次睡前口服。治疗组在对照组基础上加中药平喘汤,每天1剂,水煎分4~6次服。共8周。另设健康儿童组做对照。治疗前后采静脉血3 mL,用ELISA法检测IL-4, IL-13和IFN-γ水平。 结果 :治疗前两组哮喘疗患儿IL-4,IL-13水平均高于健康组,而IFN-γ水平则低于健康组,两者差异有显著性( P<0.01,P<0.05)。8周后治疗组IL-4,IL-13水平下降、IFN-γ水平升高,与对照组比较,差异有显著性(P<0.05)。 结论 :中西医结合治疗儿童哮喘可显著下调IL-4,IL-13及上调IFN-γ水平,从而减轻气道炎症,有效地防止哮喘的发作。

Abstract:Objective : To discuss the effect of integrated traditional Chinese and Western medicine on Th1/Th2 cytokines level in children with asthma. Method : Children with asthma were randomly divided into control group and treatment group. The control group was given Montelukast Sodium tablets for 4 mg (2-5 years old) or 5 mg (6-14 years old), once every night before sleeping. At the same time, the treatment group was given Pingchuan water decoction additionally for one tie per day , in four to six-divided doses for eight weeks. On the other hand, groups of health children were selected as blank control. Before and after treatment, the level of IL-4, IL-13 and IFN-γ were detected by elisa from 3 mL of venous blood. Result : Before treatment, IL-4 and IL-13 in two groups were obviously higher than healthy group, but IFN-γ was lower (P<0.01,P<0.05). After eight weeks, IL-4 and IL-13 in treatment group went down, but IFN-γ increased. And there were significant different compared with the control group (P<0.05). Conclusion : Treating children asthma by integrated traditional Chinese and western medicine can obviously reduce IL-4 and IL-13, increase IFN-γ, and therefore lighten the airway inflammation, prevent asthma attacks effectively.

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