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期 刊 ：中国中药杂志 2008年 33卷 11期 页码：1287.

关键词：中药配伍；缺血性心肌重塑；实验研究；

Keywords:traditional Chinese herbs compatibility, ischemic left ventricular remodeling, experimental study,

摘 要 ：目的：探讨有效组分配伍组方抗缺血性心肌重塑的可行性。方法：用结扎大鼠冠脉左前降支的方法制备缺血性心肌重塑动物模型，采用临床有效方剂银丹胶囊的饮片水煎浓缩液及相应药材提取的有效组分作为干预药物，在3 d和56 d时分别用超声诊断仪检测心功能，用HE和天狼猩红法染色观察心脏组织病理学改变。结果：56 d时饮片配伍组和有效组分配伍组皆能阻止心室恶性重塑，改善心功能，减小心肌梗死面积，降低心脏指数和心肌纤维化程度，减少梗死区和非梗死区心肌细胞凋亡数，与模型组比较差异有显著统计学意义(P<0.01，P<0.05)；有效组分配伍组作用优于饮片配伍组(P<0.05)。3 d时饮片配伍组效果不明显，但有效组分配伍组效果显著(P<0.05)。结论：有效组分配伍干预缺血性心肌重塑的效果优于饮片配伍。有效组分配伍排除了非药效物质的干扰，作用更强，效果更好。

Abstract:Objective: To investigate the effects of effective components extracted from medicines compatibility on ischemic myocardial remodeling. Method: The animal models of ischemic myocardial remodeling was copied by ligating the left anterior descending branch of coronary artery in rat.And then decoction and effective components extracted from the same medicines were administrated to rats, The heart function was detected by ultrasound diagnostic apparatus and the heart morphology was examined by Hematoxylin and Eosin, picrosirius staining respectively on the 3 rd and 56 rd day. Result: Both concentrated decoction and effective components compatibility showed good restrained effects on ventricle malignant remodeling, such as improved heart function, reduced the area of myocardial infarction, lowered heart index, mitigated the fibrosis level and decreased apoptosis cell numbers in infarction and non-infarction areas. The difference were statistically significant when compared with the control group (P<0.01, P<0.05), and effective components treated group had better effects than concentrated decoction group (P<0.05). Concentrated decoction group showed little effects on the 3 rd day, while effective components group showed significant effect (P<0.05). Conclusion: Effective components compatibility has better effects on inhibiting the process of ischemic myocardial remodeling than concentrated decoction. Effective components compatibility has better effects on ventricle malignant remodeling by eliminating the interfrence non-pharmacodynamic elements of the medicine.

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