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期 刊 ：中国中药杂志 2008年 33卷 11期 页码：1278.

关键词：远志；寡糖酯；PC12细胞；抗抑郁；

Keywords:Polygala tenuifolia, sucrose ester, PC12 cell, antidepressant,

摘 要 ：目的：研究远志的抗抑郁活性成分。方法：用色谱法分离远志的化学成分，根据波谱学分析鉴定了化合物的结构，用MTT法评价其细胞毒活性。结果从远志分离得到8个化合物，分别鉴定为：西伯利亚远志糖A₁(sibiricose A₁，1)，西伯利亚远志糖A₅(sibiricose A₅，2)，tenuifoliside A(3)，西伯利亚远志糖A₆(sibiricose A₆，4)，3，4，5-三甲氧基肉桂酸甲酯(3，4，5-trimethoxycinnamate，5)，远志酮Ⅲ(polygalaxanthone Ⅲ，6)，tenuifolioses A(7)，tenuifolioses H(8)。结论：化合物1为首次从远志中分离得到,远志中的寡糖酯类成分对谷氨酸造成的PC12细胞损伤均有一定的保护作用。

Abstract:Objective: To investigate the antidepressant components of Polygala tenuifolia. Method: The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities. Result: Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A₁ (1), sibiricose A₅ (2), tenuifoliside A (3) and 3′, 6-disinapoyl sucrose (4), sibiricose A₆ (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone Ⅲ (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds‘ activities to PC12 were observed. Conclusion: Compound 1 was isolated from this plant for the first time. Compounds 2，3 could protect PC12 cells damage induced by P. tenuifolia.

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