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期 刊 ：中国中药杂志 2007年 32卷 11期 页码：1044.

关键词：狭苞橐吾；化学成分；倍半萜；

Keywords:Ligularia intermedia, chemical constituents, sesquiterpenes,

摘 要 ：目的：研究产自山西的狭苞橐吾Ligularia intermedia的化学成分。方法：用硅胶柱色谱(CC)、制备薄层色谱(PTLC)、重结晶等方法进行分离纯化,经现代波谱技术：红外、质谱、一维和二维核磁共振谱及X-射线单晶衍射等方法对化合物进行结构鉴定。结果：分离鉴定了9个化合物,分别为：8β-hydroxyeremophil-7(11)-ene-12,8α(4β,6α)-diolide(1),8β-methoxyeremophil-7(11) -ene-12,8α(4β,6α)-diolide(2),蜂斗菜素(petasin,3),异蜂斗菜素(isopetasin,4),liguhodgsonal(5),ligudentatol(6),ligujapone(7),羽扇豆醇(lupeol,8)和羽扇豆醇棕榈酸酯(lupeol palmitate,9)。结论：其中化合物2,3,4,6,7,9为首次从狭苞橐吾中获得。

Abstract:Objective: To study the chemical constituents of Ligularia intermedia of Shanxi. Method: The compounds were isolated by column chromatography on silica gel and preparative TLC. The structures were identified by IR, MS, 1D/2DNMR spectral data and X-ray single crystal diffraction and other methods1. Result: Nine compound were isolated and identified as 8β-hydroxyeremophil-7(11)-ene-12, 8α(4β, 6α)-diolide (1), 8β-methoxyeremophil-7(11)-ene-12, 8α(4β, 6α)-diolide (2), petasin (3), isopetasin (4), liguhodgsonal (5), ligudentatol (6), ligujapone (7), lupeol (8) and lupeol palmitate (9). Conclusion: Compounds 2, 3, 4, 6, 7 and 9 were isolated from the plant for the first time.

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