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期 刊 ：中国中药杂志 2006年 31卷 07期 页码：549.

关键词：白术；药效成分；提取；超声波；响应面法；

Keywords:Atractylode macrocephala, active component, extraction, ultrasonic wave, response surface method,

摘 要 ：目的:为制备浓缩型白术颗粒饮片,以水作溶剂,用超声波强化白术有效成分的提取。方法:研究了超声波条件下影响浸提的几个因素,包括料液比、超声功率、超声时间、浸泡时间、粒度等,并通过响应面法优化工艺条件。结果:当白术颗粒度为0.1 mm,提取次数为3次,超声前浸泡时间为30 min,液固比为10∶1,超声后浸泡时间为2.6 h,超声时间为15.5 min,超声功率为531 W时,白术有效成分提取效果最佳。白术有效成分保留88.5%,浓缩1.6倍。结论:超声波方法可较好地应用于白术有效成分的提取浓缩,通过响应面法得到一个能较好预测试验结果的模型方程。

Abstract:Objective: To create Atractylode macrocephala inspissation decoction pieces.The effect of ultrasonic wave on extraction of the active components in A.macrocephala was studied in a water solution.Method: The factors including the ratio of material to liquid,ultrasonic power,ultrasonic time,soaking time,particle size etc,were studied.The best extraction method was found through the response surface method.Result: The best extraction method was found as follows: the granularity of material 0.1 mm,the repetition times of ultrasonic process 3 times,the soaking time before the ultrasonic process 30 min,the ratio of liquid to material 10∶1,the soaking time after the ultrasonic process 2.6 h,the time of the ultrasonic wave 15.5 min,the power of the ultrasonic wave 531 W,the rate of reservation of active components 88.5%,the rate of inspissation 1.6.Conclusion: The ultrasonic wave can used in the extraction of the active components in A.macrocephala and a model equation that can be used to predict the experiment was get through the response surface method.

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