Abstract:We reviewed the modern development of clinical application and experimental reseach on the prescription Biejiajian Wan(BJ),which are the basement that we will study its anti-renal fibrosis.At present,the prescription BJ is mainly applied to the treatment of chronic heptic desease.Its experimental reseach is mainly confined to the studing of anti-heptic fibrosi.Refering the scientific and technological result of anti-heptic fibrosis,we think the prescription BJ would have the effection of anti-renal fibrosis on the basis of theory of planning treatment according to diagnosis.But it has not been reported to the prescription BJ on the clinical and experimental reseach on anti-renal fibrosis.Therefore,it is very important to take on clinical reseach of the prescription BJ and discuss the effecting mechanism of anti-renal fibrosis from the level of integration,cell and molecule,which will help to enlarge the clinical application of the prescription Biejiajianwan and explained the essence of "persistent diseases injuring collateral branch of large channel" in traditional Chinese medicine.