---

期 刊 ：中国中药杂志 2003年 28卷 07期 页码：653.

关键词：益气通淋冲剂；前列腺增生；转化生长因子；碱性成纤维生长因子；血管内皮生长因子；

Keywords:Yi Qi Tong Ling Chingji, benign prostatic hyperplasia, VEGF, bFGF, TGFβ,

摘 要 ：目的:探讨益气通淋冲剂治疗前列腺增生的作用机理。方法:应用免疫组织化学技术SP法对益气通淋冲剂干预组及其对照组的大鼠前列腺增生组织标本的β₁转化生长因子(TGFβ₁),碱性成纤维生长因子(bFGF)和血管内皮生长因子(VEGF)检测。结果:VEGF和bFGF的表达对照组与各干预组有显著性差异(P<0.01),TGFβ₁的表达无统计学意义,VEGF和bFGF在对照组与益气通淋冲剂大剂量组、小剂量组及保列治组间有差别(P<0.05),对照组与益气通淋冲剂小剂量组,益气通淋冲剂大剂量组与保列治组间3种生长因子在增生前列腺组织中的表达无差别。结论:益气通淋冲剂可以使前列腺增生组织的间质组织和腺上皮萎缩,使前列腺缩小,主要作用机制是益气通淋冲剂抑制了VEGF和bFGF在前列腺增生组织中的表达。

Abstract:Objective: To study the mechanisim of Yi Qi Tong Lin Chingji in treating benign prostatic hyperplasia. Method: The expressions of VEGF, bFGF and TGFfJj in prostatic hyperplasia model rats were examined by immunohistochemistry. 8 rats were in contrastive group, 24 influenced by Yi Qi Tong Ling Chingji and Prostacar. Result: The expressions of VEGF and bFGF were significantly difference, but the exprecsion of TGFβ₁ was not significant. (P<0.01). The expression of VEGF and bFGF were significant in contrastive group to the high-dose of Yi Qi Tong Ling Chingji and Prostacar group (P<0.05) but were not significant to the low-dose of Yi Qi Tong Ling Chingji group. There was no significant difference between high-dose of Yi Qi Tong Ling Chingji and Prostacar group and three growth factors. Conclusion: Yi Qi Tong Ling Chingji inhibit the expression of VEGF and bFGF in BPH so as to decrease the volume of prostate.

---