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期 刊 ：中国中药杂志 2006年 31卷 23期 页码：1976.

关键词：杜仲木脂素部位；主动脉环；内皮细胞；钙通道；钾通道；

Keywords:EUL, noradrenaline(NE), vasodilation,

摘 要 ：目的：观察杜仲木脂素部位（EUL）对血管的舒张作用并探讨其机制。方法：以大鼠胸主动脉为标本,观察EUL对NE,KCl预收缩血管的舒张作用及对血管内皮细胞、血管平滑肌作用的影响。结果：EUL能显著舒张NE预收缩的血管,内皮去除后,该作用明显降低；KCl收缩下,EUL对主动脉环无明显舒张作用。去内皮的血管,EUL对NE在无Ca²⁺ 液中收缩幅度没有影响；使NE的量效曲线非平行右移,最大反应降低。钾通道阻断剂格列本脲孵育后能明显抑制EUL的舒血管作用。结论：杜仲木脂素部位有明显的舒血管作用,其机制与内皮依赖性有关。同时ATP敏感性K⁺ 通道也参与了EUL的舒血管作用。

Abstract:Objective: To observe vasodilation effect of EUL and its mechanism.Method: Isometric tension was recorded in isolated rat thoracic artery precontracted by noradrenaline(NE) to study the vasodilation effect of EUL, and to investigate the role of endothelial cell and vascular smooth muscle cell on vasodilation.Result: EUL was shown to significantly relax the endothelium-intact arteries precontracted by NE, relaxation had fall down on endothelium-denuded arteries. EUL did not affect the concentration-contraction curve of K⁺. NE and CaCl₂ to shift to the right with an decrease in the maximum effective response, manifesting non-competitive antagonism (P<0.01). The relaxant effect of EUL was significantly inhibited by pretreatment of endothelium-denuded aorta with potassium channel antagonist glibenclamide.Conclusion: EUL induces relaxation in rat aortic rings. The mechanisms may involve the endothelium and the activation of the potassium channels.

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